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Bidirectional associations between treatment-resistant depression and general medical conditions

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Bidirectional associations between treatment-resistant depression and general medical conditions. / Madsen, Kathrine Bang; Momen, Natalie C; Petersen, Liselotte Vogdrup; Plana-Ripoll, Oleguer; Haarman, Bartholomeus C M; Drexhage, Hemmo; Mortensen, Preben Bo; McGrath, John J; Munk-Olsen, Trine.

In: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, Vol. 51, 20.05.2021, p. 7-19.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

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APA

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MLA

Madsen, Kathrine Bang et al. "Bidirectional associations between treatment-resistant depression and general medical conditions". European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 2021, 51. 7-19. https://doi.org/10.1016/j.euroneuro.2021.04.021

Vancouver

Madsen KB, Momen NC, Petersen LV, Plana-Ripoll O, Haarman BCM, Drexhage H et al. Bidirectional associations between treatment-resistant depression and general medical conditions. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 2021 May 20;51:7-19. https://doi.org/10.1016/j.euroneuro.2021.04.021

Author

Madsen, Kathrine Bang ; Momen, Natalie C ; Petersen, Liselotte Vogdrup ; Plana-Ripoll, Oleguer ; Haarman, Bartholomeus C M ; Drexhage, Hemmo ; Mortensen, Preben Bo ; McGrath, John J ; Munk-Olsen, Trine. / Bidirectional associations between treatment-resistant depression and general medical conditions. In: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 2021 ; Vol. 51. pp. 7-19.

Bibtex

@article{c02a4ad7280545ac86f8a5dfd3c5938f,
title = "Bidirectional associations between treatment-resistant depression and general medical conditions",
abstract = "Depression is associated with general medical conditions (GMCs), but it is not known if treatment-resistant depression (TRD) affects GMC risk and vice versa. We estimated bidirectional associations between TRD and GMCs (prior and subsequent). All individuals aged 18-69 years, born and living in Denmark, with a first-time prescription for an antidepressant between 2005 and 2012 were identified in the Danish Prescription Registry (N = 154,513). TRD was defined as at least two shifts in treatment regimes. For prior GMCs, we estimated odds ratios (ORs) using conditional logistic regression comparing TRD patients with matched non-TRD controls adjusted for other GMCs and number of other GMCs. For subsequent GMCs, we used Cox regression to calculate hazard ratios (HRs) in TRD vs. non-TRD patients adjusted for age at first prescription, calendar time, other GMCs and number of other GMCs. Patients with TRD had higher prevalence of prior GMCs related to the immune or neurological systems; musculoskeletal disorders (women aOR: 1.35, 95% CI: 1.26-1.46, men aOR: 1.30, 95% CI: 1.19-1.42) and migraine (women aOR: 1.22, 95% CI: 1.09-1.36, men aOR: 1.25, 95% CI: 1.00-1.56). Subsequent GMCs were related to a broader spectrum; cardiovascular (women aHR: 1.43, 95% CI: 1.32-1.54, men aHR: 1.31, 95% CI: 1.19-1.43), endocrine (women aHR: 1.52, 95% CI: 1.37-1.67, men aHR: 1.24, 95% CI: 1.07-1.44), and neurological disorders (women aHR: 1.24, 95% CI: 1.13-1.35, men aHR: 1.19, 95% CI: 1.07-1.34). Our study presents a broad overview of comorbid medical conditions in patients with TRD and further studies are needed to explore the associations in detail.",
author = "Madsen, {Kathrine Bang} and Momen, {Natalie C} and Petersen, {Liselotte Vogdrup} and Oleguer Plana-Ripoll and Haarman, {Bartholomeus C M} and Hemmo Drexhage and Mortensen, {Preben Bo} and McGrath, {John J} and Trine Munk-Olsen",
note = "Copyright {\textcopyright} 2021. Published by Elsevier B.V.",
year = "2021",
month = may,
day = "20",
doi = "10.1016/j.euroneuro.2021.04.021",
language = "English",
volume = "51",
pages = "7--19",
journal = "European Neuropsychopharmacology",
issn = "0924-977X",
publisher = "Elsevier BV",

}

RIS

TY - JOUR

T1 - Bidirectional associations between treatment-resistant depression and general medical conditions

AU - Madsen, Kathrine Bang

AU - Momen, Natalie C

AU - Petersen, Liselotte Vogdrup

AU - Plana-Ripoll, Oleguer

AU - Haarman, Bartholomeus C M

AU - Drexhage, Hemmo

AU - Mortensen, Preben Bo

AU - McGrath, John J

AU - Munk-Olsen, Trine

N1 - Copyright © 2021. Published by Elsevier B.V.

PY - 2021/5/20

Y1 - 2021/5/20

N2 - Depression is associated with general medical conditions (GMCs), but it is not known if treatment-resistant depression (TRD) affects GMC risk and vice versa. We estimated bidirectional associations between TRD and GMCs (prior and subsequent). All individuals aged 18-69 years, born and living in Denmark, with a first-time prescription for an antidepressant between 2005 and 2012 were identified in the Danish Prescription Registry (N = 154,513). TRD was defined as at least two shifts in treatment regimes. For prior GMCs, we estimated odds ratios (ORs) using conditional logistic regression comparing TRD patients with matched non-TRD controls adjusted for other GMCs and number of other GMCs. For subsequent GMCs, we used Cox regression to calculate hazard ratios (HRs) in TRD vs. non-TRD patients adjusted for age at first prescription, calendar time, other GMCs and number of other GMCs. Patients with TRD had higher prevalence of prior GMCs related to the immune or neurological systems; musculoskeletal disorders (women aOR: 1.35, 95% CI: 1.26-1.46, men aOR: 1.30, 95% CI: 1.19-1.42) and migraine (women aOR: 1.22, 95% CI: 1.09-1.36, men aOR: 1.25, 95% CI: 1.00-1.56). Subsequent GMCs were related to a broader spectrum; cardiovascular (women aHR: 1.43, 95% CI: 1.32-1.54, men aHR: 1.31, 95% CI: 1.19-1.43), endocrine (women aHR: 1.52, 95% CI: 1.37-1.67, men aHR: 1.24, 95% CI: 1.07-1.44), and neurological disorders (women aHR: 1.24, 95% CI: 1.13-1.35, men aHR: 1.19, 95% CI: 1.07-1.34). Our study presents a broad overview of comorbid medical conditions in patients with TRD and further studies are needed to explore the associations in detail.

AB - Depression is associated with general medical conditions (GMCs), but it is not known if treatment-resistant depression (TRD) affects GMC risk and vice versa. We estimated bidirectional associations between TRD and GMCs (prior and subsequent). All individuals aged 18-69 years, born and living in Denmark, with a first-time prescription for an antidepressant between 2005 and 2012 were identified in the Danish Prescription Registry (N = 154,513). TRD was defined as at least two shifts in treatment regimes. For prior GMCs, we estimated odds ratios (ORs) using conditional logistic regression comparing TRD patients with matched non-TRD controls adjusted for other GMCs and number of other GMCs. For subsequent GMCs, we used Cox regression to calculate hazard ratios (HRs) in TRD vs. non-TRD patients adjusted for age at first prescription, calendar time, other GMCs and number of other GMCs. Patients with TRD had higher prevalence of prior GMCs related to the immune or neurological systems; musculoskeletal disorders (women aOR: 1.35, 95% CI: 1.26-1.46, men aOR: 1.30, 95% CI: 1.19-1.42) and migraine (women aOR: 1.22, 95% CI: 1.09-1.36, men aOR: 1.25, 95% CI: 1.00-1.56). Subsequent GMCs were related to a broader spectrum; cardiovascular (women aHR: 1.43, 95% CI: 1.32-1.54, men aHR: 1.31, 95% CI: 1.19-1.43), endocrine (women aHR: 1.52, 95% CI: 1.37-1.67, men aHR: 1.24, 95% CI: 1.07-1.44), and neurological disorders (women aHR: 1.24, 95% CI: 1.13-1.35, men aHR: 1.19, 95% CI: 1.07-1.34). Our study presents a broad overview of comorbid medical conditions in patients with TRD and further studies are needed to explore the associations in detail.

U2 - 10.1016/j.euroneuro.2021.04.021

DO - 10.1016/j.euroneuro.2021.04.021

M3 - Journal article

C2 - 34023798

VL - 51

SP - 7

EP - 19

JO - European Neuropsychopharmacology

JF - European Neuropsychopharmacology

SN - 0924-977X

ER -