Bidirectional associations between asthma and types of mental disorders

Xiaoqin Liu; Oleguer Plana-Ripoll; John J McGrath; Liselotte V Petersen; Shyamali C Dharmage; Natalie C Momen

doi:10.1016/j.jaip.2022.11.027

Bidirectional associations between asthma and types of mental disorders

Xiaoqin Liu, Oleguer Plana-Ripoll, John J McGrath, Liselotte V Petersen, Shyamali C Dharmage, Natalie C Momen

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Abstract

Background: Asthma and mental disorders frequently co-occur. Studies of their comorbidity have generally focused on associations related to a subset of mental disorders. Objective: To estimate bidirectional associations between asthma and 10 broad types of mental disorders. Methods: In a population-based cohort study, including all individuals born in Denmark between 1955 and 2011 (N = 5,053,471), we considered diagnoses of comorbid mental disorders among those with asthma, and vice versa, between 2000 and 2016. We used Cox regression models to calculate overall and time-dependent hazard ratios for mental disorder–asthma pairs and competing-risks survival analyses to estimate absolute risks. Results: Altogether, 376,756 individuals were identified as having an incident mental disorder and 364,063 incident asthma during follow-up. An increased risk was seen for all bidirectional mental disorder–asthma pairs. Following an asthma diagnosis, adjusted hazard ratios for different subsequent mental disorders ranged from 1.75 (95% CI, 1.64-1.87) for organic disorders to 2.75 (95% CI, 2.69-2.81) for personality disorders. Following a prior mental disorder diagnosis, hazard ratios for asthma ranged from 1.06 (95% CI, 1.00-1.12) for developmental disorders to 2.33 (95% CI, 2.28-2.39) for substance use disorders. Risks varied with time since prior disorder diagnosis but remained elevated. Cumulative incidence of (1) asthma after a mental disorder and (2) a mental disorder after asthma was higher in those with prior disorders than in matched reference groups. Conclusions: Our findings provide evidence of bidirectional associations between asthma and each of the mental disorder types, suggesting possible shared etiological factors or pathophysiologic processes.

Original language	English
Journal	The Journal of Allergy and Clinical Immunology: In Practice
Volume	11
Issue	3
Pages (from-to)	799-808.e14
DOIs	https://doi.org/10.1016/j.jaip.2022.11.027
Publication status	Published - Mar 2023

Keywords

Asthma
Comorbidity
Epidemiology
Mental disorder
Register-based research
Denmark/epidemiology
Mental Disorders/epidemiology
Humans
Substance-Related Disorders
Asthma/epidemiology
Cohort Studies

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10.1016/j.jaip.2022.11.027

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@article{affa2377339d43a0938813f446d4ede8,

title = "Bidirectional associations between asthma and types of mental disorders",

abstract = "Background: Asthma and mental disorders frequently co-occur. Studies of their comorbidity have generally focused on associations related to a subset of mental disorders. Objective: To estimate bidirectional associations between asthma and 10 broad types of mental disorders. Methods: In a population-based cohort study, including all individuals born in Denmark between 1955 and 2011 (N = 5,053,471), we considered diagnoses of comorbid mental disorders among those with asthma, and vice versa, between 2000 and 2016. We used Cox regression models to calculate overall and time-dependent hazard ratios for mental disorder–asthma pairs and competing-risks survival analyses to estimate absolute risks. Results: Altogether, 376,756 individuals were identified as having an incident mental disorder and 364,063 incident asthma during follow-up. An increased risk was seen for all bidirectional mental disorder–asthma pairs. Following an asthma diagnosis, adjusted hazard ratios for different subsequent mental disorders ranged from 1.75 (95% CI, 1.64-1.87) for organic disorders to 2.75 (95% CI, 2.69-2.81) for personality disorders. Following a prior mental disorder diagnosis, hazard ratios for asthma ranged from 1.06 (95% CI, 1.00-1.12) for developmental disorders to 2.33 (95% CI, 2.28-2.39) for substance use disorders. Risks varied with time since prior disorder diagnosis but remained elevated. Cumulative incidence of (1) asthma after a mental disorder and (2) a mental disorder after asthma was higher in those with prior disorders than in matched reference groups. Conclusions: Our findings provide evidence of bidirectional associations between asthma and each of the mental disorder types, suggesting possible shared etiological factors or pathophysiologic processes.",

keywords = "Asthma, Comorbidity, Epidemiology, Mental disorder, Register-based research, Denmark/epidemiology, Mental Disorders/epidemiology, Humans, Substance-Related Disorders, Asthma/epidemiology, Cohort Studies",

author = "Xiaoqin Liu and Oleguer Plana-Ripoll and McGrath, {John J} and Petersen, {Liselotte V} and Dharmage, {Shyamali C} and Momen, {Natalie C}",

note = "Copyright {\textcopyright} 2022. Published by Elsevier Inc.",

year = "2023",

month = mar,

doi = "10.1016/j.jaip.2022.11.027",

language = "English",

volume = "11",

pages = "799--808.e14",

journal = "The Journal of Allergy and Clinical Immunology: In Practice",

issn = "2213-2201",

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number = "3",

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Bidirectional associations between asthma and types of mental disorders. / Liu, Xiaoqin ; Plana-Ripoll, Oleguer ; McGrath, John J et al.
In: The Journal of Allergy and Clinical Immunology: In Practice, Vol. 11, No. 3, 03.2023, p. 799-808.e14.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

TY - JOUR

T1 - Bidirectional associations between asthma and types of mental disorders

AU - Liu, Xiaoqin

AU - Plana-Ripoll, Oleguer

AU - McGrath, John J

AU - Petersen, Liselotte V

AU - Dharmage, Shyamali C

AU - Momen, Natalie C

PY - 2023/3

Y1 - 2023/3

N2 - Background: Asthma and mental disorders frequently co-occur. Studies of their comorbidity have generally focused on associations related to a subset of mental disorders. Objective: To estimate bidirectional associations between asthma and 10 broad types of mental disorders. Methods: In a population-based cohort study, including all individuals born in Denmark between 1955 and 2011 (N = 5,053,471), we considered diagnoses of comorbid mental disorders among those with asthma, and vice versa, between 2000 and 2016. We used Cox regression models to calculate overall and time-dependent hazard ratios for mental disorder–asthma pairs and competing-risks survival analyses to estimate absolute risks. Results: Altogether, 376,756 individuals were identified as having an incident mental disorder and 364,063 incident asthma during follow-up. An increased risk was seen for all bidirectional mental disorder–asthma pairs. Following an asthma diagnosis, adjusted hazard ratios for different subsequent mental disorders ranged from 1.75 (95% CI, 1.64-1.87) for organic disorders to 2.75 (95% CI, 2.69-2.81) for personality disorders. Following a prior mental disorder diagnosis, hazard ratios for asthma ranged from 1.06 (95% CI, 1.00-1.12) for developmental disorders to 2.33 (95% CI, 2.28-2.39) for substance use disorders. Risks varied with time since prior disorder diagnosis but remained elevated. Cumulative incidence of (1) asthma after a mental disorder and (2) a mental disorder after asthma was higher in those with prior disorders than in matched reference groups. Conclusions: Our findings provide evidence of bidirectional associations between asthma and each of the mental disorder types, suggesting possible shared etiological factors or pathophysiologic processes.

AB - Background: Asthma and mental disorders frequently co-occur. Studies of their comorbidity have generally focused on associations related to a subset of mental disorders. Objective: To estimate bidirectional associations between asthma and 10 broad types of mental disorders. Methods: In a population-based cohort study, including all individuals born in Denmark between 1955 and 2011 (N = 5,053,471), we considered diagnoses of comorbid mental disorders among those with asthma, and vice versa, between 2000 and 2016. We used Cox regression models to calculate overall and time-dependent hazard ratios for mental disorder–asthma pairs and competing-risks survival analyses to estimate absolute risks. Results: Altogether, 376,756 individuals were identified as having an incident mental disorder and 364,063 incident asthma during follow-up. An increased risk was seen for all bidirectional mental disorder–asthma pairs. Following an asthma diagnosis, adjusted hazard ratios for different subsequent mental disorders ranged from 1.75 (95% CI, 1.64-1.87) for organic disorders to 2.75 (95% CI, 2.69-2.81) for personality disorders. Following a prior mental disorder diagnosis, hazard ratios for asthma ranged from 1.06 (95% CI, 1.00-1.12) for developmental disorders to 2.33 (95% CI, 2.28-2.39) for substance use disorders. Risks varied with time since prior disorder diagnosis but remained elevated. Cumulative incidence of (1) asthma after a mental disorder and (2) a mental disorder after asthma was higher in those with prior disorders than in matched reference groups. Conclusions: Our findings provide evidence of bidirectional associations between asthma and each of the mental disorder types, suggesting possible shared etiological factors or pathophysiologic processes.

KW - Asthma

KW - Comorbidity

KW - Epidemiology

KW - Mental disorder

KW - Register-based research

KW - Denmark/epidemiology

KW - Mental Disorders/epidemiology

KW - Humans

KW - Substance-Related Disorders

KW - Asthma/epidemiology

KW - Cohort Studies

U2 - 10.1016/j.jaip.2022.11.027

DO - 10.1016/j.jaip.2022.11.027

M3 - Journal article

C2 - 36481421

SN - 2213-2201

VL - 11

SP - 799-808.e14

JO - The Journal of Allergy and Clinical Immunology: In Practice

JF - The Journal of Allergy and Clinical Immunology: In Practice

IS - 3

ER -

Bidirectional associations between asthma and types of mental disorders

Abstract

Keywords

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