Bestrophin is important for the rhythmic but not the tonic contraction in rat mesenteric small arteries

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We have previously characterized a cGMP-dependent Ca(2+)-activated Cl(-) current in vascular smooth muscle cells (SMCs) and have shown its dependence on bestrophin-3 expression. We hypothesize that this current is important for synchronization of SMCs in the vascular wall. In the present study, we aimed to test this hypothesis by transfecting rat mesenteric small arteries in vivo with siRNA specifically targeting bestrophin-3.
Original languageEnglish
Book seriesAdvances in Cardiovascular Research
Pages (from-to)685-93
Number of pages9
Publication statusPublished - 2011

    Research areas

  • Animals, Arginine Vasopressin, Calcium, Chloride Channels, Male, Mesenteric Arteries, Norepinephrine, RNA, Messenger, RNA, Small Interfering, Rats, Rats, Wistar, Transfection, Vasoconstriction

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