Abstract
We have previously characterized a cGMP-dependent Ca(2+)-activated Cl(-) current in vascular smooth muscle cells (SMCs) and have shown its dependence on bestrophin-3 expression. We hypothesize that this current is important for synchronization of SMCs in the vascular wall. In the present study, we aimed to test this hypothesis by transfecting rat mesenteric small arteries in vivo with siRNA specifically targeting bestrophin-3.
Original language | English |
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Book series | Advances in Cardiovascular Research |
Volume | 91 |
Issue | 4 |
Pages (from-to) | 685-93 |
Number of pages | 9 |
ISSN | 2159-1717 |
DOIs | |
Publication status | Published - 2011 |
Keywords
- Animals
- Arginine Vasopressin
- Calcium
- Chloride Channels
- Male
- Mesenteric Arteries
- Norepinephrine
- RNA, Messenger
- RNA, Small Interfering
- Rats
- Rats, Wistar
- Transfection
- Vasoconstriction