Benzo(a)pyrene diol epoxides as intermediates in nucleic acid binding in vivo and in vitro

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • I.B. Weinstein, Denmark
  • A.M. Jeffrey, Denmark
  • K.W. Jennette, Denmark
  • S.H. Blobstein, Denmark
  • R.G. Harvey, Denmark
  • C. Harris, Denmark
  • Herman Autrup
  • H. Kasai, Denmark
  • K. Nakanishi, Denmark
  • Institute of Environmental and Occupational Medicine
Evidence has been obtained that a specific isomer of a diol epoxide derivative of benzo(a)pyrene, (+/-)-7 beta,8alpha-dihydroxy-9alpha, 10alpha-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene, is an intermediate in the binding of benzo(a)pyrene to RNA in cultured bovine bronchial mucosa. An adduct is formed between position 10 of this derivative and the 2-amino group of guanine.
Original languageEnglish
JournalScience
Volume193
Issue4253
Pages (from-to)1067-1069
Number of pages3
ISSN0036-8075
Publication statusPublished - 13 Aug 1976

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