Bacterial signatures and their inflammatory potentials associated with prostate cancer

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DOI

  • Holger Brüggemann
  • Munir A Al-Zeer, Institute of Biotechnology, Department of Applied Biochemistry, Technical University of Berlin, Berlin, Germany.

Chronic inflammation can create a microenvironment that can contribute to the formation of prostate pathologies. Far less well understood is the origin of inflammation in the prostate. One potential source is microbial infections of the prostate. This review summarizes recent findings regarding the presence of bacteria in the prostate and the dysbiosis of bacterial populations in the urinary tract and the gastrointestinal tract related to prostate cancer, thereby focusing on next-generation sequencing (NGS)-generated data. The current limitations regarding NGS-based detection methods and other difficulties in the quest for a microbial etiology for prostate cancer are discussed. We then focus on a few bacterial species, including Cutibacterium acnes and Escherichia coli that are often NGS-detected in prostatic tissue specimens, and discuss their possible contribution as initiator or enhancer of prostate inflammation and prostate carcinogenesis.

Original languageEnglish
Book seriesAPMIS Supplementum
Volume128
Issue2
Pages (from-to)80-91
Number of pages12
ISSN0903-465X
DOIs
Publication statusPublished - 2020

    Research areas

  • Cutibacterium acnes, Prostate cancer, bacteria, infection, inflammation, microbiota

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