Autophagosome Maturation and Fusion

Fulvio Reggiori; Christian Ungermann

doi:10.1016/j.jmb.2017.01.002

Autophagosome Maturation and Fusion

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187 Citations (Scopus)

Abstract

Macroautophagy, or simply autophagy, is a degradative pathway that delivers cytoplasmic components, including cytosol and organelles, to the lysosome in double-membrane vesicles called autophagosomes. This process is initiated at the pre-autophagosomal structure or phagophore assembly site and involves a number of highly conserved autophagy-related proteins. These support the generation and conversion of an open membranous cistern known as the phagophore or isolation membrane into a closed autophagosome. Within this review, we will focus on recent insights into the molecular events following the sealing/completion of an autophagosome, which lead to its maturation and subsequent fusion with endosomes/lysosomes.

Original language	English
Journal	Journal of Molecular Biology
Volume	429
Issue	4
Pages (from-to)	486-496
Number of pages	11
ISSN	0022-2836
DOIs	https://doi.org/10.1016/j.jmb.2017.01.002
Publication status	Published - 17 Feb 2017

Keywords

Animals
Autophagosomes/physiology
Autophagy
Cytosol/metabolism
Endosomes/physiology
Humans
Lysosomes/physiology
Mammals/metabolism
SNARE Proteins/metabolism
Yeasts/metabolism

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10.1016/j.jmb.2017.01.002

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title = "Autophagosome Maturation and Fusion",

abstract = "Macroautophagy, or simply autophagy, is a degradative pathway that delivers cytoplasmic components, including cytosol and organelles, to the lysosome in double-membrane vesicles called autophagosomes. This process is initiated at the pre-autophagosomal structure or phagophore assembly site and involves a number of highly conserved autophagy-related proteins. These support the generation and conversion of an open membranous cistern known as the phagophore or isolation membrane into a closed autophagosome. Within this review, we will focus on recent insights into the molecular events following the sealing/completion of an autophagosome, which lead to its maturation and subsequent fusion with endosomes/lysosomes.",

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author = "Fulvio Reggiori and Christian Ungermann",

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T1 - Autophagosome Maturation and Fusion

AU - Reggiori, Fulvio

AU - Ungermann, Christian

PY - 2017/2/17

Y1 - 2017/2/17

N2 - Macroautophagy, or simply autophagy, is a degradative pathway that delivers cytoplasmic components, including cytosol and organelles, to the lysosome in double-membrane vesicles called autophagosomes. This process is initiated at the pre-autophagosomal structure or phagophore assembly site and involves a number of highly conserved autophagy-related proteins. These support the generation and conversion of an open membranous cistern known as the phagophore or isolation membrane into a closed autophagosome. Within this review, we will focus on recent insights into the molecular events following the sealing/completion of an autophagosome, which lead to its maturation and subsequent fusion with endosomes/lysosomes.

AB - Macroautophagy, or simply autophagy, is a degradative pathway that delivers cytoplasmic components, including cytosol and organelles, to the lysosome in double-membrane vesicles called autophagosomes. This process is initiated at the pre-autophagosomal structure or phagophore assembly site and involves a number of highly conserved autophagy-related proteins. These support the generation and conversion of an open membranous cistern known as the phagophore or isolation membrane into a closed autophagosome. Within this review, we will focus on recent insights into the molecular events following the sealing/completion of an autophagosome, which lead to its maturation and subsequent fusion with endosomes/lysosomes.

KW - Animals

KW - Autophagosomes/physiology

KW - Autophagy

KW - Cytosol/metabolism

KW - Endosomes/physiology

KW - Humans

KW - Lysosomes/physiology

KW - Mammals/metabolism

KW - SNARE Proteins/metabolism

KW - Yeasts/metabolism

U2 - 10.1016/j.jmb.2017.01.002

DO - 10.1016/j.jmb.2017.01.002

M3 - Review

C2 - 28077293

SN - 0022-2836

VL - 429

SP - 486

EP - 496

JO - Journal of Molecular Biology

JF - Journal of Molecular Biology

IS - 4

ER -

Autophagosome Maturation and Fusion

Abstract

Keywords

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