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Automated EEG source imaging: A retrospective, blinded clinical validation study

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  • Amir G. Baroumand, Universiteit Gent
  • ,
  • Pieter van Mierlo, Universiteit Gent
  • ,
  • Gregor Strobbe, Epilog
  • ,
  • Lars H. Pinborg, Rigshospitalet
  • ,
  • Martin Fabricius, Rigshospitalet
  • ,
  • Guido Rubboli, Danish Epilepsy Centre, Dianalund
  • ,
  • Anne Mette Leffers, Hvidovre Universitets Hospital, Hvidovre
  • ,
  • Peter Uldall, Rigshospitalet
  • ,
  • Bo Jespersen, Rigshospitalet
  • ,
  • Jannick Brennum, Rigshospitalet
  • ,
  • Otto Mølby Henriksen, Rigshospitalet
  • ,
  • Sándor Beniczky

Objective: To evaluate the accuracy of automated EEG source imaging (ESI) in localizing epileptogenic zone. Methods: Long-term EEG, recorded with the standard 25-electrode array of the IFCN, from 41 consecutive patients with focal epilepsy who underwent resective surgery, were analyzed blinded to the surgical outcome. The automated analysis comprised spike-detection, clustering and source imaging at the half-rising time and at the peak of each spike-cluster, using individual head-models with six tissue-layers and a distributed source model (sLORETA). The fully automated approach presented ESI of the cluster with the highest number of spikes, at the half-rising time. In addition, a physician involved in the presurgical evaluation of the patients, evaluated the automated ESI results (up to four clusters per patient) in clinical context and selected the dominant cluster and the analysis time-point (semi-automated approach). The reference standard was location of the resected area and outcome one year after operation. Results: Accuracy was 61% (95% CI: 45–76%) for the fully automated approach and 78% (95% CI: 62–89%) for the semi-automated approach. Conclusion: Automated ESI has an accuracy similar to previously reported neuroimaging methods. Significance: Automated ESI will contribute to increased utilization of source imaging in the presurgical evaluation of patients with epilepsy.

Original languageEnglish
JournalClinical Neurophysiology
Volume129
Issue11
Pages (from-to)2403-2410
Number of pages8
ISSN1388-2457
DOIs
Publication statusPublished - 1 Nov 2018

Bibliographical note

Copyright © 2018 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.

    Research areas

  • Automation, EEG, Epilepsy, Presurgical evaluation, Source imaging, Source localization

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