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Auditory deviance detection in the human insula: An intracranial EEG study

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  • Alejandro O Blenkmann, Department of Psychology, University of Oslo, Norway. Electronic address: ablenkmann@gmail.com.
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  • Santiago Collavini, Studies in Neurosciences and Complex Systems, National Scientific and Technical Research Council, El Cruce Hospital, Arturo Jauretche National University, Argentina. Electronic address: santiagocollavini@gmail.com.
  • ,
  • James Lubell
  • Anaïs Llorens, Department of Psychology, University of Oslo, Norway; Department of Neurosurgery, Oslo University Hospital, Rikshospitalet, Norway. Electronic address: anaisllorens@hotmail.com.
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  • Ingrid Funderud, Department of Psychology, University of Oslo, Norway. Electronic address: ingridfunderud@hotmail.com.
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  • Jugoslav Ivanovic, Department of Neurosurgery, Oslo University Hospital, Rikshospitalet, Norway. Electronic address: jugiva@ous-hf.no.
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  • Pål G Larsson, Department of Neurosurgery, Oslo University Hospital, Rikshospitalet, Norway. Electronic address: pall@ous-hf.no.
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  • Torstein R Meling, Department of Neurosurgery, Oslo University Hospital, Rikshospitalet, Norway. Electronic address: torsteinrmeling@gmail.com.
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  • Tristan Bekinschtein, Psychology Department, University of Cambridge, UK. Electronic address: trisbek@gmail.com.
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  • Silvia Kochen, Studies in Neurosciences and Complex Systems, National Scientific and Technical Research Council, El Cruce Hospital, Arturo Jauretche National University, Argentina. Electronic address: skochen@gmail.com.
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  • Tor Endestad, Department of Psychology, University of Oslo, Norway; Department of Neuropsychology, Helgeland Hospital, Mosjøen, Norway. Electronic address: tor.endestad@psykologi.uio.no.
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  • Robert T Knight, Helen Wills Neuroscience Institute and Department of Psychology, University of California at Berkeley, USA. Electronic address: rtknight@berkeley.edu.
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  • Anne-Kristin Solbakk, Department of Psychology, University of Oslo, Norway; Department of Neurosurgery, Oslo University Hospital, Rikshospitalet, Norway; Department of Neuropsychology, Helgeland Hospital, Mosjøen, Norway. Electronic address: a.k.solbakk@psykologi.uio.no.

The human insula is known to be involved in auditory processing, but knowledge about its precise functional role and the underlying electrophysiology is limited. To assess its role in automatic auditory deviance detection we analyzed the EEG high frequency activity (HFA; 75-145 Hz) and ERPs from 90 intracranial insular channels across 16 patients undergoing pre-surgical intracranial monitoring for epilepsy treatment. Subjects passively listened to a stream of standard and deviant tones differing in four physical dimensions: intensity, frequency, location or time. HFA responses to auditory stimuli were found in the short and long gyri, and the anterior, superior, and inferior segments of the circular sulcus of the insular cortex. Only a subset of channels in the inferior segment of the circular sulcus of the insula showed HFA deviance detection responses, i.e., a greater and longer latency response to specific deviants relative to standards. Auditory deviancy processing was also later in the insula when compared with the superior temporal cortex. ERP results were more widespread and supported the HFA insular findings. These results provide evidence that the human insula is engaged during auditory deviance detection.

Original languageEnglish
JournalCortex
Volume121
Pages (from-to)189-200
Number of pages12
ISSN0010-9452
DOIs
Publication statusPublished - Dec 2019
Externally publishedYes

Bibliographical note

Copyright © 2019 Elsevier Ltd. All rights reserved.

    Research areas

  • CORTEX, Deviance detection, FUTURE, GAMMA ACTIVITY, High frequency activity, Insula, MISMATCH NEGATIVITY MMN, Mismatch negativity (MMN), NETWORKS, ORGANIZATION, POTENTIALS, PREDICTION, Predictive coding, REGION, STIMULUS CHANGE

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