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Atopic eczema and major cardiovascular outcomes: A systematic review and meta-analysis of population-based studies

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Atopic eczema and major cardiovascular outcomes : A systematic review and meta-analysis of population-based studies. / Ascott, Anna; Mulick, Amy; Yu, Ashley M.; Prieto-Merino, David; Schmidt, Morten; Abuabara, Katrina; Smeeth, Liam; Roberts, Amanda; Langan, Sinéad M.

In: Journal of Allergy and Clinical Immunology, Vol. 143, No. 5, 05.2019, p. 1821-1829.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

Harvard

Ascott, A, Mulick, A, Yu, AM, Prieto-Merino, D, Schmidt, M, Abuabara, K, Smeeth, L, Roberts, A & Langan, SM 2019, 'Atopic eczema and major cardiovascular outcomes: A systematic review and meta-analysis of population-based studies', Journal of Allergy and Clinical Immunology, vol. 143, no. 5, pp. 1821-1829. https://doi.org/10.1016/j.jaci.2018.11.030

APA

Ascott, A., Mulick, A., Yu, A. M., Prieto-Merino, D., Schmidt, M., Abuabara, K., Smeeth, L., Roberts, A., & Langan, S. M. (2019). Atopic eczema and major cardiovascular outcomes: A systematic review and meta-analysis of population-based studies. Journal of Allergy and Clinical Immunology, 143(5), 1821-1829. https://doi.org/10.1016/j.jaci.2018.11.030

CBE

Ascott A, Mulick A, Yu AM, Prieto-Merino D, Schmidt M, Abuabara K, Smeeth L, Roberts A, Langan SM. 2019. Atopic eczema and major cardiovascular outcomes: A systematic review and meta-analysis of population-based studies. Journal of Allergy and Clinical Immunology. 143(5):1821-1829. https://doi.org/10.1016/j.jaci.2018.11.030

MLA

Vancouver

Ascott A, Mulick A, Yu AM, Prieto-Merino D, Schmidt M, Abuabara K et al. Atopic eczema and major cardiovascular outcomes: A systematic review and meta-analysis of population-based studies. Journal of Allergy and Clinical Immunology. 2019 May;143(5):1821-1829. https://doi.org/10.1016/j.jaci.2018.11.030

Author

Ascott, Anna ; Mulick, Amy ; Yu, Ashley M. ; Prieto-Merino, David ; Schmidt, Morten ; Abuabara, Katrina ; Smeeth, Liam ; Roberts, Amanda ; Langan, Sinéad M. / Atopic eczema and major cardiovascular outcomes : A systematic review and meta-analysis of population-based studies. In: Journal of Allergy and Clinical Immunology. 2019 ; Vol. 143, No. 5. pp. 1821-1829.

Bibtex

@article{89f0b5afabb04b689a0793766e092d11,
title = "Atopic eczema and major cardiovascular outcomes: A systematic review and meta-analysis of population-based studies",
abstract = "Background: Atopic eczema is a common inflammatory skin disease. Various inflammatory conditions have been linked to cardiovascular disease, a major cause of global mortality and morbidity. Objective: We sought to systematically review and meta-analyze population-based studies assessing associations between atopic eczema and specific cardiovascular outcomes. Methods: MEDLINE, Embase, and Global Health were searched from inception to December 2017. We obtained pooled estimates using random-effects meta-analyses. We used a multivariate Bayesian meta-regression model to estimate the slope of effect of increasing atopic eczema severity on cardiovascular outcomes. Results: Nineteen relevant studies were included. The effects of atopic eczema reported in cross-sectional studies were heterogeneous, with no evidence for pooled associations with angina, myocardial infarction, heart failure, or stroke. In cohort studies atopic eczema was associated with increased risk of myocardial infarction (n = 4; relative risk [RR], 1.12; 95% CI, 1.00-1.25), stroke (n = 4; RR, 1.10; 95% CI, 1.03-1.17), ischemic stroke n = 4; RR, 1.17; 95% CI, 1.14-1.20), angina (n = 2; RR, 1.18; 95% CI, 1.13-1.24), and heart failure (n = 2; RR, 1.26; 95% CI, 1.05-1.51). Prediction intervals were wide for myocardial infarction and stroke. The risk of cardiovascular outcomes appeared to increase with increasing severity (mean RR increase between severity categories, 1.15; 95% credibility interval, 1.09-1.21; uncertainty interval, 1.04-1.28). Conclusion: Significant associations with cardiovascular outcomes were more common in cohort studies but with considerable between-study heterogeneity. Increasing atopic eczema severity was associated with increased risk of cardiovascular outcomes. Improved awareness among stakeholders regarding this small but significant association is warranted.",
keywords = "angina, atopic dermatitis, Atopic eczema, cardiovascular death, cardiovascular outcomes, heart failure, ischemic stroke, myocardial infarction, risk factors, stroke",
author = "Anna Ascott and Amy Mulick and Yu, {Ashley M.} and David Prieto-Merino and Morten Schmidt and Katrina Abuabara and Liam Smeeth and Amanda Roberts and Langan, {Sin{\'e}ad M.}",
year = "2019",
month = may,
doi = "10.1016/j.jaci.2018.11.030",
language = "English",
volume = "143",
pages = "1821--1829",
journal = "Journal of Allergy and Clinical Immunology",
issn = "0091-6749",
publisher = "Mosby, Inc",
number = "5",

}

RIS

TY - JOUR

T1 - Atopic eczema and major cardiovascular outcomes

T2 - A systematic review and meta-analysis of population-based studies

AU - Ascott, Anna

AU - Mulick, Amy

AU - Yu, Ashley M.

AU - Prieto-Merino, David

AU - Schmidt, Morten

AU - Abuabara, Katrina

AU - Smeeth, Liam

AU - Roberts, Amanda

AU - Langan, Sinéad M.

PY - 2019/5

Y1 - 2019/5

N2 - Background: Atopic eczema is a common inflammatory skin disease. Various inflammatory conditions have been linked to cardiovascular disease, a major cause of global mortality and morbidity. Objective: We sought to systematically review and meta-analyze population-based studies assessing associations between atopic eczema and specific cardiovascular outcomes. Methods: MEDLINE, Embase, and Global Health were searched from inception to December 2017. We obtained pooled estimates using random-effects meta-analyses. We used a multivariate Bayesian meta-regression model to estimate the slope of effect of increasing atopic eczema severity on cardiovascular outcomes. Results: Nineteen relevant studies were included. The effects of atopic eczema reported in cross-sectional studies were heterogeneous, with no evidence for pooled associations with angina, myocardial infarction, heart failure, or stroke. In cohort studies atopic eczema was associated with increased risk of myocardial infarction (n = 4; relative risk [RR], 1.12; 95% CI, 1.00-1.25), stroke (n = 4; RR, 1.10; 95% CI, 1.03-1.17), ischemic stroke n = 4; RR, 1.17; 95% CI, 1.14-1.20), angina (n = 2; RR, 1.18; 95% CI, 1.13-1.24), and heart failure (n = 2; RR, 1.26; 95% CI, 1.05-1.51). Prediction intervals were wide for myocardial infarction and stroke. The risk of cardiovascular outcomes appeared to increase with increasing severity (mean RR increase between severity categories, 1.15; 95% credibility interval, 1.09-1.21; uncertainty interval, 1.04-1.28). Conclusion: Significant associations with cardiovascular outcomes were more common in cohort studies but with considerable between-study heterogeneity. Increasing atopic eczema severity was associated with increased risk of cardiovascular outcomes. Improved awareness among stakeholders regarding this small but significant association is warranted.

AB - Background: Atopic eczema is a common inflammatory skin disease. Various inflammatory conditions have been linked to cardiovascular disease, a major cause of global mortality and morbidity. Objective: We sought to systematically review and meta-analyze population-based studies assessing associations between atopic eczema and specific cardiovascular outcomes. Methods: MEDLINE, Embase, and Global Health were searched from inception to December 2017. We obtained pooled estimates using random-effects meta-analyses. We used a multivariate Bayesian meta-regression model to estimate the slope of effect of increasing atopic eczema severity on cardiovascular outcomes. Results: Nineteen relevant studies were included. The effects of atopic eczema reported in cross-sectional studies were heterogeneous, with no evidence for pooled associations with angina, myocardial infarction, heart failure, or stroke. In cohort studies atopic eczema was associated with increased risk of myocardial infarction (n = 4; relative risk [RR], 1.12; 95% CI, 1.00-1.25), stroke (n = 4; RR, 1.10; 95% CI, 1.03-1.17), ischemic stroke n = 4; RR, 1.17; 95% CI, 1.14-1.20), angina (n = 2; RR, 1.18; 95% CI, 1.13-1.24), and heart failure (n = 2; RR, 1.26; 95% CI, 1.05-1.51). Prediction intervals were wide for myocardial infarction and stroke. The risk of cardiovascular outcomes appeared to increase with increasing severity (mean RR increase between severity categories, 1.15; 95% credibility interval, 1.09-1.21; uncertainty interval, 1.04-1.28). Conclusion: Significant associations with cardiovascular outcomes were more common in cohort studies but with considerable between-study heterogeneity. Increasing atopic eczema severity was associated with increased risk of cardiovascular outcomes. Improved awareness among stakeholders regarding this small but significant association is warranted.

KW - angina

KW - atopic dermatitis

KW - Atopic eczema

KW - cardiovascular death

KW - cardiovascular outcomes

KW - heart failure

KW - ischemic stroke

KW - myocardial infarction

KW - risk factors

KW - stroke

UR - http://www.scopus.com/inward/record.url?scp=85059692101&partnerID=8YFLogxK

U2 - 10.1016/j.jaci.2018.11.030

DO - 10.1016/j.jaci.2018.11.030

M3 - Review

C2 - 30576754

AN - SCOPUS:85059692101

VL - 143

SP - 1821

EP - 1829

JO - Journal of Allergy and Clinical Immunology

JF - Journal of Allergy and Clinical Immunology

SN - 0091-6749

IS - 5

ER -