Asymptotic theory of generalized estimating equations based on jack-knife pseudo-observations

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Abstract

A general asymptotic theory of estimates from estimating functions based on jack-knife pseudo-observations is established by requiring that the underlying estimator can be expressed as a smooth functional of the empirical distribution. Using results in p-variation norms, the theory is applied to important estimators from time-to-event analysis, namely the Kaplan–Meier estimator and the Aalen–Johansen estimator in a competing risks model, and the corresponding estimators of restricted mean survival and cause-specific lifetime lost. Under an assumption of completely independent censorings, this allows for estimating parameters in regression models of survival, cumulative incidences, restricted mean survival, and cause-specific lifetime lost. Considering estimators as functionals and applying results in p-variation norms is apparently an excellent way of studying the asymptotics of such estimators.
Original languageEnglish
JournalAnnals of Statistics
Volume45
Issue5
Pages (from-to)1988-2015
Number of pages28
ISSN0090-5364
DOIs
Publication statusPublished - 31 Oct 2017

Keywords

  • U-statistics
  • functional differentiability
  • p-variation
  • pseudo-observation method
  • pseudo-values
  • von Mises expansion

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