Asymmetric Organocatalytic Synthesis of Complex Cyclopenta[b]quinoline Derivatives

TY - JOUR

T1 - Asymmetric Organocatalytic Synthesis of Complex Cyclopenta[b]quinoline Derivatives

AU - Jensen, Kim L

AU - Dickmeiss, Gustav

AU - Donslund, Bjarke

AU - Poulsen, Pernille Hartveit

AU - Jørgensen, Karl Anker

PY - 2011/7/15

Y1 - 2011/7/15

N2 - An efficient one-pot procedure that provides a direct access to polycyclic hexahydrocyclopenta[b]quinoline derivatives having five stereogenic centers has been developed. The system displays great tolerance toward different aldehydes, anilines, and nitroalkenes. The products are obtained in high yields and excellent enantio- and diastereoselectivities.

AB - An efficient one-pot procedure that provides a direct access to polycyclic hexahydrocyclopenta[b]quinoline derivatives having five stereogenic centers has been developed. The system displays great tolerance toward different aldehydes, anilines, and nitroalkenes. The products are obtained in high yields and excellent enantio- and diastereoselectivities.

U2 - 10.1021/ol201328s

DO - 10.1021/ol201328s

M3 - Journal article

C2 - 21661751

SN - 1523-7060

VL - 13

SP - 3678

EP - 3681

JO - Organic Letters

JF - Organic Letters

IS - 14

ER -