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Associations between intelligence, verbal working memory and processing speed in parents with schizophrenia or bipolar disorder and their 7-year old offspring

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  • Aja Neergaard Greve
  • Jens Richardt M. Jepsen, University of Copenhagen, Denmark
  • Erik Lykke Mortensen, University of Copenhagen, Denmark
  • Rudolf Uher, Dalhousie Univ, Dalhousie University, Dept Biol, Canada
  • Lynn Mackenzie, Dalhousie Univ, Dalhousie University, Dept Biol, Canada
  • Leslie Foldager
  • Ditte Lou Langhoff Gantriis
  • Birgitte Klee Burton, Mental Hlth Serv Capital Reg, Child & Adolescent Mental Hlth Ctr, Denmark
  • Ditte Vestbjerg Ellersgaard, University of Copenhagen, Denmark
  • Camilla Jerlang Christiani, University of Copenhagen, Denmark
  • Katrine Søborg Spang, University of Copenhagen, Denmark
  • Nicoline Hemager, University of Copenhagen, Denmark
  • Maria Toft Henriksen, Aarhus University Hospital, Risskov, Denmark
  • Kate Kold Zahle
  • ,
  • Henriette Brockdorff Stadsgaard
  • Anne A E Thorup, University of Copenhagen, Denmark
  • Merete Nordentoft, University of Copenhagen, Denmark
  • Kerstin Plessen, University of Copenhagen, Denmark
  • Ole Mors
  • Vibeke Fuglsang Bliksted
Background
Neurocognitive phenotypes may contribute to understanding the pathway leading from genes to psychopathology. We aimed to investigate associations of intelligence, processing speed and verbal working memory between parents and offspring in families with schizophrenia, bipolar disorder and controls.

MethodsData are from The Danish High Risk and Resilience Study – VIA7, a population-based nationwide cohort identified through Danish Registries. Participants are 522 children aged 7 with no, one, or two parents with schizophrenia or bipolar disorder and biological parents. Control children were matched to children from the schizophrenia group (age, gender, and municipality). Children at familial risk of bipolar disorder were comparison group. Child assessors were blinded to risk status. Main Outcomes were intelligence measured with Reynolds Intellectual Screening Test (RIST), verbal working memory assessed with letter number sequencing (LNS) and processing speed assessed with Coding (WISC-IV/WAIS-IV).

ResultsWe examined 434 index parents (151 schizophrenia, 100 bipolar disorder and 183 controls, mean (SD) age 39.7 (5.7), 264 (61%) females), 443 co-parents (mean (SD) age 40.1 (5.4), 210 (47%) females) and 489 children (mean (SD) age 7.8 (0.2), 231 (47%) females). Children′s intelligence was associated with index parents’ intelligence (B = 0.40, 95% CI: 0.28;0.52, p < 0.001) and co-parents’ intelligence (B = 0.16, 95% CI: 0.03;0.28, p = 0.012). Children’s processing speed was associated with index parents’ processing speed (B = 0.07, 95% CI: 0.02;0.12, p = 0.007), co-parents’ processing speed (B = 0.09, 95% CI: 0.04;0.15, p < 0.001), group (schizophrenia: B = -1.92, 95% CI: -3.63;-0.21, p = 0.028) and gender of child (male: B = -4.55, 95% CI: -4.98; -2.12, p < 0.001). Children’s working memory was associated with index parents’ LNS score (B=0.25, 95% CI: 0.13;0.37, p < 0.001), co-parents’ working memory (B = 0.23, 95% CI: 0.09;0.37, p = 0.001), group (schizophrenia: B = -1.02, 95% CI: -0.89;-0.16, p = 0.020) and gender of child (male: B = -0.85, 95% CI: -1.60;-0.11, p = 0.025).

DiscussionFindings showed associations of neurocognitive phenotypes between parents and offspring. These associations do not differ markedly between schizophrenia, bipolar disorder and controls.
Original languageEnglish
JournalSchizophrenia Bulletin
Volume44
IssueSuppl_1
Pages (from-to)S252-S252
ISSN0586-7614
Publication statusPublished - 1 Apr 2018
Event6th Biennial Conference of the Schizophrenia-International-Research-Society (SIRS) - Florence, Italy
Duration: 4 Apr 20188 Apr 2018

Conference

Conference6th Biennial Conference of the Schizophrenia-International-Research-Society (SIRS)
CountryItaly
CityFlorence
Period04/04/201808/04/2018

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