Department of Economics and Business Economics

Associations Between Autoimmune Diseases and Attention-Deficit/Hyperactivity Disorder: A Nationwide Study

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Standard

Associations Between Autoimmune Diseases and Attention-Deficit/Hyperactivity Disorder : A Nationwide Study. / Nielsen, Philip Finn Rising; Benros, Michael Eriksen; Dalsgaard, Søren.

In: Journal of the American Academy of Child and Adolescent Psychiatry, Vol. 56, No. 3, 2017, p. 234-240.e1.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Nielsen, PFR, Benros, ME & Dalsgaard, S 2017, 'Associations Between Autoimmune Diseases and Attention-Deficit/Hyperactivity Disorder: A Nationwide Study', Journal of the American Academy of Child and Adolescent Psychiatry, vol. 56, no. 3, pp. 234-240.e1. https://doi.org/10.1016/j.jaac.2016.12.010

APA

Nielsen, P. F. R., Benros, M. E., & Dalsgaard, S. (2017). Associations Between Autoimmune Diseases and Attention-Deficit/Hyperactivity Disorder: A Nationwide Study. Journal of the American Academy of Child and Adolescent Psychiatry, 56(3), 234-240.e1. https://doi.org/10.1016/j.jaac.2016.12.010

CBE

Nielsen PFR, Benros ME, Dalsgaard S. 2017. Associations Between Autoimmune Diseases and Attention-Deficit/Hyperactivity Disorder: A Nationwide Study. Journal of the American Academy of Child and Adolescent Psychiatry. 56(3):234-240.e1. https://doi.org/10.1016/j.jaac.2016.12.010

MLA

Nielsen, Philip Finn Rising, Michael Eriksen Benros, and Søren Dalsgaard. "Associations Between Autoimmune Diseases and Attention-Deficit/Hyperactivity Disorder: A Nationwide Study". Journal of the American Academy of Child and Adolescent Psychiatry. 2017, 56(3). 234-240.e1. https://doi.org/10.1016/j.jaac.2016.12.010

Vancouver

Nielsen PFR, Benros ME, Dalsgaard S. Associations Between Autoimmune Diseases and Attention-Deficit/Hyperactivity Disorder: A Nationwide Study. Journal of the American Academy of Child and Adolescent Psychiatry. 2017;56(3):234-240.e1. https://doi.org/10.1016/j.jaac.2016.12.010

Author

Nielsen, Philip Finn Rising ; Benros, Michael Eriksen ; Dalsgaard, Søren. / Associations Between Autoimmune Diseases and Attention-Deficit/Hyperactivity Disorder : A Nationwide Study. In: Journal of the American Academy of Child and Adolescent Psychiatry. 2017 ; Vol. 56, No. 3. pp. 234-240.e1.

Bibtex

@article{ddbc8451ba7c4feaaa7a1911712accda,
title = "Associations Between Autoimmune Diseases and Attention-Deficit/Hyperactivity Disorder: A Nationwide Study",
abstract = "OBJECTIVE: Recent studies have suggested that autoimmune diseases and immune activation play a part in the pathogenesis of different neurodevelopmental disorders. This study investigated the association between a personal history and a family history of autoimmune disease and the risk of developing attention-deficit/hyperactivity disorder (ADHD).METHOD: A cohort was formed of all singletons born in Denmark from 1990 to 2007, resulting in a study population of 983,680 individuals followed from 1995 to 2012. Information on autoimmune diseases was obtained from the Danish National Hospital Register. Individuals with ADHD were identified through the Danish National Hospital Register and the Danish Psychiatric Central Register.RESULTS: In total, 23,645 children were diagnosed with ADHD during the study period. Autoimmune disease in the individual was associated with an increased risk of ADHD by an incidence rate ratio of 1.24 (95% CI 1.10-1.40). The primary analyses associated maternal autoimmune disease with ADHD in the offspring (incidence rate ratio 1.12, 95% CI 1.06-1.19), whereas a paternal history of autoimmune diseases was not significantly associated with ADHD in the offspring. In exploratory analyses, an increased risk of ADHD was observed for children with a family history of thyrotoxicosis, type 1 diabetes, autoimmune hepatitis, psoriasis, and ankylosing spondylitis.CONCLUSION: A personal history and a maternal history of autoimmune disease were associated with an increased risk of ADHD. The previously reported association between type 1 diabetes and ADHD was confirmed. In addition, specific parental autoimmune diseases were associated with ADHD in offspring.",
keywords = "attention-deficit/hyperactivity disorder, autoimmune disease, autoimmunity, comorbidity",
author = "Nielsen, {Philip Finn Rising} and Benros, {Michael Eriksen} and S{\o}ren Dalsgaard",
note = "Copyright {\textcopyright} 2016 American Academy of Child and Adolescent Psychiatry. Published by Elsevier Inc. All rights reserved.",
year = "2017",
doi = "10.1016/j.jaac.2016.12.010",
language = "English",
volume = "56",
pages = "234--240.e1",
journal = "American Academy of Child and Adolescent Psychiatry. Journal",
issn = "0890-8567",
publisher = "Elsevier BV",
number = "3",

}

RIS

TY - JOUR

T1 - Associations Between Autoimmune Diseases and Attention-Deficit/Hyperactivity Disorder

T2 - A Nationwide Study

AU - Nielsen, Philip Finn Rising

AU - Benros, Michael Eriksen

AU - Dalsgaard, Søren

N1 - Copyright © 2016 American Academy of Child and Adolescent Psychiatry. Published by Elsevier Inc. All rights reserved.

PY - 2017

Y1 - 2017

N2 - OBJECTIVE: Recent studies have suggested that autoimmune diseases and immune activation play a part in the pathogenesis of different neurodevelopmental disorders. This study investigated the association between a personal history and a family history of autoimmune disease and the risk of developing attention-deficit/hyperactivity disorder (ADHD).METHOD: A cohort was formed of all singletons born in Denmark from 1990 to 2007, resulting in a study population of 983,680 individuals followed from 1995 to 2012. Information on autoimmune diseases was obtained from the Danish National Hospital Register. Individuals with ADHD were identified through the Danish National Hospital Register and the Danish Psychiatric Central Register.RESULTS: In total, 23,645 children were diagnosed with ADHD during the study period. Autoimmune disease in the individual was associated with an increased risk of ADHD by an incidence rate ratio of 1.24 (95% CI 1.10-1.40). The primary analyses associated maternal autoimmune disease with ADHD in the offspring (incidence rate ratio 1.12, 95% CI 1.06-1.19), whereas a paternal history of autoimmune diseases was not significantly associated with ADHD in the offspring. In exploratory analyses, an increased risk of ADHD was observed for children with a family history of thyrotoxicosis, type 1 diabetes, autoimmune hepatitis, psoriasis, and ankylosing spondylitis.CONCLUSION: A personal history and a maternal history of autoimmune disease were associated with an increased risk of ADHD. The previously reported association between type 1 diabetes and ADHD was confirmed. In addition, specific parental autoimmune diseases were associated with ADHD in offspring.

AB - OBJECTIVE: Recent studies have suggested that autoimmune diseases and immune activation play a part in the pathogenesis of different neurodevelopmental disorders. This study investigated the association between a personal history and a family history of autoimmune disease and the risk of developing attention-deficit/hyperactivity disorder (ADHD).METHOD: A cohort was formed of all singletons born in Denmark from 1990 to 2007, resulting in a study population of 983,680 individuals followed from 1995 to 2012. Information on autoimmune diseases was obtained from the Danish National Hospital Register. Individuals with ADHD were identified through the Danish National Hospital Register and the Danish Psychiatric Central Register.RESULTS: In total, 23,645 children were diagnosed with ADHD during the study period. Autoimmune disease in the individual was associated with an increased risk of ADHD by an incidence rate ratio of 1.24 (95% CI 1.10-1.40). The primary analyses associated maternal autoimmune disease with ADHD in the offspring (incidence rate ratio 1.12, 95% CI 1.06-1.19), whereas a paternal history of autoimmune diseases was not significantly associated with ADHD in the offspring. In exploratory analyses, an increased risk of ADHD was observed for children with a family history of thyrotoxicosis, type 1 diabetes, autoimmune hepatitis, psoriasis, and ankylosing spondylitis.CONCLUSION: A personal history and a maternal history of autoimmune disease were associated with an increased risk of ADHD. The previously reported association between type 1 diabetes and ADHD was confirmed. In addition, specific parental autoimmune diseases were associated with ADHD in offspring.

KW - attention-deficit/hyperactivity disorder

KW - autoimmune disease

KW - autoimmunity

KW - comorbidity

UR - http://www.scopus.com/inward/record.url?scp=85009776744&partnerID=8YFLogxK

U2 - 10.1016/j.jaac.2016.12.010

DO - 10.1016/j.jaac.2016.12.010

M3 - Journal article

C2 - 28219489

VL - 56

SP - 234-240.e1

JO - American Academy of Child and Adolescent Psychiatry. Journal

JF - American Academy of Child and Adolescent Psychiatry. Journal

SN - 0890-8567

IS - 3

ER -