Association of Rheumatoid Arthritis in Pregnancy With School Performance of Offspring: A Danish Nationwide Register-Based Study

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Association of Rheumatoid Arthritis in Pregnancy With School Performance of Offspring : A Danish Nationwide Register-Based Study. / Knudsen, Signe S; Simard, Julia F; Christensen, Jakob et al.

In: Arthritis Care & Research, Vol. 73, No. 7, 07.2021, p. 975-982.

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Knudsen, Signe S ; Simard, Julia F ; Christensen, Jakob et al. / Association of Rheumatoid Arthritis in Pregnancy With School Performance of Offspring : A Danish Nationwide Register-Based Study. In: Arthritis Care & Research. 2021 ; Vol. 73, No. 7. pp. 975-982.

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@article{c01a8654aae14d999127dfbce6a31156,
title = "Association of Rheumatoid Arthritis in Pregnancy With School Performance of Offspring: A Danish Nationwide Register-Based Study",
abstract = "OBJECTIVES: To examine the overall cognitive development of children exposed to maternal rheumatoid arthritis (RA) in utero by comparing their school test scores, to those of their peers.METHODS: Children born in Denmark 1995-2008, and listed in the National School Test Register were included (n=738,862). Children exposed to maternal RA were identified through linkage of national registers. In separate analyses, exposure was subdivided according to maternal serostatus. Preclinical maternal RA was included as a separate exposure. The Danish National School Tests are mandatory, standardized tests. Results from all reading tests (grades 2, 4, 6 and 8) and mathematics tests (grades 3 and 6) from 2010-2017 were included. Test scores were compared according to maternal RA exposure, for each test separately, using linear regressions.RESULTS: we identified 934 children exposed to maternal RA in utero. There were no differences in reading test scores, between maternal RA exposed and unexposed children. RA exposed children scored poorer in both mathematics tests (adjusted differences of mean score: -0.14 standard deviations (SD) (95% CI: -0.23; -0.06 ) and -0.16 SD (95% CI: -0.26 -0.07 ). There was no appreciable difference between children by maternal RA serostatus. Children exposed to preclinical RA (n=589) showed the same pattern of performance as children exposed to RA.CONCLUSIONS: RA exposed children scored slightly poorer in mathematics tests, but performed as well as their unexposed peers in the reading tests. The results do not suggest that RA in pregnancy has a major impact on offspring school performance.",
author = "Knudsen, {Signe S} and Simard, {Julia F} and Jakob Christensen and Laursen, {Thomas M} and Deleuran, {Bent W} and Bech, {Bodil H}",
note = "This article is protected by copyright. All rights reserved.",
year = "2021",
month = jul,
doi = "10.1002/acr.24223",
language = "English",
volume = "73",
pages = "975--982",
journal = "Arthritis Care & Research",
issn = "2151-464X",
publisher = "Jossey-Bass",
number = "7",

}

RIS

TY - JOUR

T1 - Association of Rheumatoid Arthritis in Pregnancy With School Performance of Offspring

T2 - A Danish Nationwide Register-Based Study

AU - Knudsen, Signe S

AU - Simard, Julia F

AU - Christensen, Jakob

AU - Laursen, Thomas M

AU - Deleuran, Bent W

AU - Bech, Bodil H

N1 - This article is protected by copyright. All rights reserved.

PY - 2021/7

Y1 - 2021/7

N2 - OBJECTIVES: To examine the overall cognitive development of children exposed to maternal rheumatoid arthritis (RA) in utero by comparing their school test scores, to those of their peers.METHODS: Children born in Denmark 1995-2008, and listed in the National School Test Register were included (n=738,862). Children exposed to maternal RA were identified through linkage of national registers. In separate analyses, exposure was subdivided according to maternal serostatus. Preclinical maternal RA was included as a separate exposure. The Danish National School Tests are mandatory, standardized tests. Results from all reading tests (grades 2, 4, 6 and 8) and mathematics tests (grades 3 and 6) from 2010-2017 were included. Test scores were compared according to maternal RA exposure, for each test separately, using linear regressions.RESULTS: we identified 934 children exposed to maternal RA in utero. There were no differences in reading test scores, between maternal RA exposed and unexposed children. RA exposed children scored poorer in both mathematics tests (adjusted differences of mean score: -0.14 standard deviations (SD) (95% CI: -0.23; -0.06 ) and -0.16 SD (95% CI: -0.26 -0.07 ). There was no appreciable difference between children by maternal RA serostatus. Children exposed to preclinical RA (n=589) showed the same pattern of performance as children exposed to RA.CONCLUSIONS: RA exposed children scored slightly poorer in mathematics tests, but performed as well as their unexposed peers in the reading tests. The results do not suggest that RA in pregnancy has a major impact on offspring school performance.

AB - OBJECTIVES: To examine the overall cognitive development of children exposed to maternal rheumatoid arthritis (RA) in utero by comparing their school test scores, to those of their peers.METHODS: Children born in Denmark 1995-2008, and listed in the National School Test Register were included (n=738,862). Children exposed to maternal RA were identified through linkage of national registers. In separate analyses, exposure was subdivided according to maternal serostatus. Preclinical maternal RA was included as a separate exposure. The Danish National School Tests are mandatory, standardized tests. Results from all reading tests (grades 2, 4, 6 and 8) and mathematics tests (grades 3 and 6) from 2010-2017 were included. Test scores were compared according to maternal RA exposure, for each test separately, using linear regressions.RESULTS: we identified 934 children exposed to maternal RA in utero. There were no differences in reading test scores, between maternal RA exposed and unexposed children. RA exposed children scored poorer in both mathematics tests (adjusted differences of mean score: -0.14 standard deviations (SD) (95% CI: -0.23; -0.06 ) and -0.16 SD (95% CI: -0.26 -0.07 ). There was no appreciable difference between children by maternal RA serostatus. Children exposed to preclinical RA (n=589) showed the same pattern of performance as children exposed to RA.CONCLUSIONS: RA exposed children scored slightly poorer in mathematics tests, but performed as well as their unexposed peers in the reading tests. The results do not suggest that RA in pregnancy has a major impact on offspring school performance.

U2 - 10.1002/acr.24223

DO - 10.1002/acr.24223

M3 - Journal article

C2 - 32339372

VL - 73

SP - 975

EP - 982

JO - Arthritis Care & Research

JF - Arthritis Care & Research

SN - 2151-464X

IS - 7

ER -