TY - JOUR
T1 - Association of healthy lifestyle factors and genetic liability with bipolar disorder
T2 - Findings from the UK Biobank
AU - Li, Guoxian
AU - He, Qida
AU - Sun, Mengtong
AU - Ma, Ze
AU - Zhao, Hanqing
AU - Wang, Yu
AU - Feng, Zhaolong
AU - Li, Tongxing
AU - Chu, Jiadong
AU - Hu, Wei
AU - Chen, Xuanli
AU - Han, Qiang
AU - Sun, Na
AU - Liu, Xiaoqin
AU - Sun, Hongpeng
AU - Shen, Yueping
PY - 2024/11/1
Y1 - 2024/11/1
N2 - Background: The interplay between genetic and lifestyle factors in the development of bipolar disorder (BD) remains unclear. Methods: A cohort study was carried out on 365,517 participants from the UK Biobank. Lifestyle scores, based on smoking, physical activity, diet, alcohol consumption, sedentary behavior, sleep duration, and social contact, were grouped as favorable (scores 6–7), intermediate (scores 4–5), or unfavorable (scores 0–3). The BD polygenic risk score (PRS) was also categorized into high, intermediate, and low-risk groups using PRS tertiles. Cox regression models determined hazard ratios (HRs) and 95 % confidence intervals (CIs) for BD. Results: During the 12.9-year follow-up, 529 individuals developed BD. Comparing those with favorable lifestyles to those with unfavorable participants, the HR of developing BD was 3.28 (95 % CI, 2.76–3.89). Similarly, individuals with a high PRS had a risk of 3.20 (95 % CI, 2.83–3.63) compared to those with a low PRS. Notably, individuals with both a high PRS and an unfavorable lifestyle had a significantly higher risk of BD (HR = 6.31, 95 % CI, 4.14–9.63) compared to those with a low PRS and a favorable lifestyle. Additionally, the interaction between PRS and lifestyle contributed an additional risk, with a relative excess risk of 1.74 (95 % CI, 0.40–3.07) and an attributable proportion due to the interaction of 0.37 (95 % CI, 0.16–0.58). Conclusions: Our findings suggest that genetic liability for BD, measured as PRS, and lifestyle have an additive effect on the risk of developing BD. A favorable lifestyle was associated with a reduced risk of developing BD.
AB - Background: The interplay between genetic and lifestyle factors in the development of bipolar disorder (BD) remains unclear. Methods: A cohort study was carried out on 365,517 participants from the UK Biobank. Lifestyle scores, based on smoking, physical activity, diet, alcohol consumption, sedentary behavior, sleep duration, and social contact, were grouped as favorable (scores 6–7), intermediate (scores 4–5), or unfavorable (scores 0–3). The BD polygenic risk score (PRS) was also categorized into high, intermediate, and low-risk groups using PRS tertiles. Cox regression models determined hazard ratios (HRs) and 95 % confidence intervals (CIs) for BD. Results: During the 12.9-year follow-up, 529 individuals developed BD. Comparing those with favorable lifestyles to those with unfavorable participants, the HR of developing BD was 3.28 (95 % CI, 2.76–3.89). Similarly, individuals with a high PRS had a risk of 3.20 (95 % CI, 2.83–3.63) compared to those with a low PRS. Notably, individuals with both a high PRS and an unfavorable lifestyle had a significantly higher risk of BD (HR = 6.31, 95 % CI, 4.14–9.63) compared to those with a low PRS and a favorable lifestyle. Additionally, the interaction between PRS and lifestyle contributed an additional risk, with a relative excess risk of 1.74 (95 % CI, 0.40–3.07) and an attributable proportion due to the interaction of 0.37 (95 % CI, 0.16–0.58). Conclusions: Our findings suggest that genetic liability for BD, measured as PRS, and lifestyle have an additive effect on the risk of developing BD. A favorable lifestyle was associated with a reduced risk of developing BD.
KW - Bipolar disorder
KW - Cohort study
KW - Healthy lifestyle
KW - Polygenic risk score
KW - UK Biobank
UR - http://www.scopus.com/inward/record.url?scp=85201392904&partnerID=8YFLogxK
U2 - 10.1016/j.jad.2024.08.011
DO - 10.1016/j.jad.2024.08.011
M3 - Journal article
C2 - 39137837
SN - 0165-0327
VL - 364
SP - 279
EP - 285
JO - Journal of Affective Disorders
JF - Journal of Affective Disorders
ER -