Association of healthy lifestyle factors and genetic liability with bipolar disorder: Findings from the UK Biobank

Guoxian Li, Qida He, Mengtong Sun, Ze Ma, Hanqing Zhao, Yu Wang, Zhaolong Feng, Tongxing Li, Jiadong Chu, Wei Hu, Xuanli Chen, Qiang Han, Na Sun, Xiaoqin Liu, Hongpeng Sun, Yueping Shen

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Abstract

Background: The interplay between genetic and lifestyle factors in the development of bipolar disorder (BD) remains unclear. Methods: A cohort study was carried out on 365,517 participants from the UK Biobank. Lifestyle scores, based on smoking, physical activity, diet, alcohol consumption, sedentary behavior, sleep duration, and social contact, were grouped as favorable (scores 6–7), intermediate (scores 4–5), or unfavorable (scores 0–3). The BD polygenic risk score (PRS) was also categorized into high, intermediate, and low-risk groups using PRS tertiles. Cox regression models determined hazard ratios (HRs) and 95 % confidence intervals (CIs) for BD. Results: During the 12.9-year follow-up, 529 individuals developed BD. Comparing those with favorable lifestyles to those with unfavorable participants, the HR of developing BD was 3.28 (95 % CI, 2.76–3.89). Similarly, individuals with a high PRS had a risk of 3.20 (95 % CI, 2.83–3.63) compared to those with a low PRS. Notably, individuals with both a high PRS and an unfavorable lifestyle had a significantly higher risk of BD (HR = 6.31, 95 % CI, 4.14–9.63) compared to those with a low PRS and a favorable lifestyle. Additionally, the interaction between PRS and lifestyle contributed an additional risk, with a relative excess risk of 1.74 (95 % CI, 0.40–3.07) and an attributable proportion due to the interaction of 0.37 (95 % CI, 0.16–0.58). Conclusions: Our findings suggest that genetic liability for BD, measured as PRS, and lifestyle have an additive effect on the risk of developing BD. A favorable lifestyle was associated with a reduced risk of developing BD.

Original languageEnglish
JournalJournal of Affective Disorders
Volume364
Pages (from-to)279-285
Number of pages7
ISSN0165-0327
DOIs
Publication statusPublished - 1 Nov 2024

Keywords

  • Bipolar disorder
  • Cohort study
  • Healthy lifestyle
  • Polygenic risk score
  • UK Biobank

Fingerprint

Dive into the research topics of 'Association of healthy lifestyle factors and genetic liability with bipolar disorder: Findings from the UK Biobank'. Together they form a unique fingerprint.

Cite this