Department of Economics and Business Economics

Association of Genetic Risk Variants With Attention-Deficit/Hyperactivity Disorder Trajectories in the General Population

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Standard

Association of Genetic Risk Variants With Attention-Deficit/Hyperactivity Disorder Trajectories in the General Population. / Riglin, Lucy; Collishaw, Stephan; Thapar, Ajay K; Dalsgaard, Søren; Langley, Kate; Smith, George Davey; Stergiakouli, Evie; Maughan, Barbara; O'Donovan, Michael C; Thapar, Anita.

In: JAMA Psychiatry, Vol. 73, No. 12, 2016, p. 1285-1292.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Riglin, L, Collishaw, S, Thapar, AK, Dalsgaard, S, Langley, K, Smith, GD, Stergiakouli, E, Maughan, B, O'Donovan, MC & Thapar, A 2016, 'Association of Genetic Risk Variants With Attention-Deficit/Hyperactivity Disorder Trajectories in the General Population', JAMA Psychiatry, vol. 73, no. 12, pp. 1285-1292. https://doi.org/10.1001/jamapsychiatry.2016.2817

APA

Riglin, L., Collishaw, S., Thapar, A. K., Dalsgaard, S., Langley, K., Smith, G. D., Stergiakouli, E., Maughan, B., O'Donovan, M. C., & Thapar, A. (2016). Association of Genetic Risk Variants With Attention-Deficit/Hyperactivity Disorder Trajectories in the General Population. JAMA Psychiatry, 73(12), 1285-1292. https://doi.org/10.1001/jamapsychiatry.2016.2817

CBE

Riglin L, Collishaw S, Thapar AK, Dalsgaard S, Langley K, Smith GD, Stergiakouli E, Maughan B, O'Donovan MC, Thapar A. 2016. Association of Genetic Risk Variants With Attention-Deficit/Hyperactivity Disorder Trajectories in the General Population. JAMA Psychiatry. 73(12):1285-1292. https://doi.org/10.1001/jamapsychiatry.2016.2817

MLA

Vancouver

Author

Riglin, Lucy ; Collishaw, Stephan ; Thapar, Ajay K ; Dalsgaard, Søren ; Langley, Kate ; Smith, George Davey ; Stergiakouli, Evie ; Maughan, Barbara ; O'Donovan, Michael C ; Thapar, Anita. / Association of Genetic Risk Variants With Attention-Deficit/Hyperactivity Disorder Trajectories in the General Population. In: JAMA Psychiatry. 2016 ; Vol. 73, No. 12. pp. 1285-1292.

Bibtex

@article{edec512a6a4040ec8bb1e52b359d724d,
title = "Association of Genetic Risk Variants With Attention-Deficit/Hyperactivity Disorder Trajectories in the General Population",
abstract = "Importance: Attention-deficit/hyperactivity disorder (ADHD) is a heritable neurodevelopmental disorder that shows clinical and genetic overlap with other childhood neurodevelopmental disorders. Levels of ADHD symptoms typically decline across childhood and adolescence, although they remain elevated for some individuals. The determinants of symptom persistence and decline are not yet fully understood.Objectives: To test the hypothesis that genetic risk variant load for ADHD (indexed by polygenic risk scores [PRS]), but not for other psychiatric disorders, is associated with population-based ADHD symptom trajectories across childhood and adolescence, and to examine whether higher genetic liability for ADHD is correlated with total number of additional neurodevelopmental disorders (multimorbidity) in childhood.Design, Setting, and Participants: The Avon Longitudinal Study of Parents and Children, an ongoing prospective population-based cohort study, has been collecting data on 14 701 children, including 9757 with data on symptoms of ADHD at multiple time points, since September 6, 1990. The primary exposure variables, PRS, were generated using results of a genome-wide association study from the Psychiatric Genomics Consortium. Childhood multimorbidity scores (ages 7-9 years) were measured by total impairments in 4 domains known to share genetic liability with ADHD: IQ, social communication, pragmatic language, and conduct. Data analysis was conducted from March 1 to September 8, 2016.Main Outcomes and Measures: Attention-deficit/hyperactivity disorder symptom trajectories from ages 4 to 17 years (7 time points).Results: Among 9757 children with data on symptoms of ADHD at multiple time points (age range, 4-17 years; 4968 boys and 4789 girls), 4 ADHD symptom trajectories were identified: low (82.6%), intermediate (7.7%), childhood-limited (5.8%), and persistent (3.9%). Mean (SE) PRS for ADHD were higher in children in the persistent trajectory (0.254 [0.069]) compared with each of the other 3 trajectories (low, -0.018 [0.014], χ21 = 14.67, P < .001, odds ratio, 1.31; intermediate, 0.054 [0.055], χ21 = 4.70, P = .03, odds ratio, 1.22; and childhood-limited, 0.017 [0.060], χ21 = 6.50, P = .01, odds ratio, 1.27). Findings were specific to PRS for ADHD; PRS for other psychiatric conditions did not differ across trajectories. The proportion of children with multimorbidity was also highest in those in the persistent trajectory (42.5%; 95% CI, 33.9%-51.1%; P < .001) and was associated with persistence of ADHD symptoms independent of PRS.Conclusions and Relevance: Persistence of ADHD symptoms across childhood and adolescence in the general population is associated with higher PRS for ADHD. Childhood multimorbidity was also associated with persistence of ADHD symptoms and may help to identify children with ADHD whose symptoms are most likely to continue into adolescence.",
author = "Lucy Riglin and Stephan Collishaw and Thapar, {Ajay K} and S{\o}ren Dalsgaard and Kate Langley and Smith, {George Davey} and Evie Stergiakouli and Barbara Maughan and O'Donovan, {Michael C} and Anita Thapar",
year = "2016",
doi = "10.1001/jamapsychiatry.2016.2817",
language = "English",
volume = "73",
pages = "1285--1292",
journal = "J A M A Psychiatry",
issn = "0003-990X",
publisher = "The JAMA Network",
number = "12",

}

RIS

TY - JOUR

T1 - Association of Genetic Risk Variants With Attention-Deficit/Hyperactivity Disorder Trajectories in the General Population

AU - Riglin, Lucy

AU - Collishaw, Stephan

AU - Thapar, Ajay K

AU - Dalsgaard, Søren

AU - Langley, Kate

AU - Smith, George Davey

AU - Stergiakouli, Evie

AU - Maughan, Barbara

AU - O'Donovan, Michael C

AU - Thapar, Anita

PY - 2016

Y1 - 2016

N2 - Importance: Attention-deficit/hyperactivity disorder (ADHD) is a heritable neurodevelopmental disorder that shows clinical and genetic overlap with other childhood neurodevelopmental disorders. Levels of ADHD symptoms typically decline across childhood and adolescence, although they remain elevated for some individuals. The determinants of symptom persistence and decline are not yet fully understood.Objectives: To test the hypothesis that genetic risk variant load for ADHD (indexed by polygenic risk scores [PRS]), but not for other psychiatric disorders, is associated with population-based ADHD symptom trajectories across childhood and adolescence, and to examine whether higher genetic liability for ADHD is correlated with total number of additional neurodevelopmental disorders (multimorbidity) in childhood.Design, Setting, and Participants: The Avon Longitudinal Study of Parents and Children, an ongoing prospective population-based cohort study, has been collecting data on 14 701 children, including 9757 with data on symptoms of ADHD at multiple time points, since September 6, 1990. The primary exposure variables, PRS, were generated using results of a genome-wide association study from the Psychiatric Genomics Consortium. Childhood multimorbidity scores (ages 7-9 years) were measured by total impairments in 4 domains known to share genetic liability with ADHD: IQ, social communication, pragmatic language, and conduct. Data analysis was conducted from March 1 to September 8, 2016.Main Outcomes and Measures: Attention-deficit/hyperactivity disorder symptom trajectories from ages 4 to 17 years (7 time points).Results: Among 9757 children with data on symptoms of ADHD at multiple time points (age range, 4-17 years; 4968 boys and 4789 girls), 4 ADHD symptom trajectories were identified: low (82.6%), intermediate (7.7%), childhood-limited (5.8%), and persistent (3.9%). Mean (SE) PRS for ADHD were higher in children in the persistent trajectory (0.254 [0.069]) compared with each of the other 3 trajectories (low, -0.018 [0.014], χ21 = 14.67, P < .001, odds ratio, 1.31; intermediate, 0.054 [0.055], χ21 = 4.70, P = .03, odds ratio, 1.22; and childhood-limited, 0.017 [0.060], χ21 = 6.50, P = .01, odds ratio, 1.27). Findings were specific to PRS for ADHD; PRS for other psychiatric conditions did not differ across trajectories. The proportion of children with multimorbidity was also highest in those in the persistent trajectory (42.5%; 95% CI, 33.9%-51.1%; P < .001) and was associated with persistence of ADHD symptoms independent of PRS.Conclusions and Relevance: Persistence of ADHD symptoms across childhood and adolescence in the general population is associated with higher PRS for ADHD. Childhood multimorbidity was also associated with persistence of ADHD symptoms and may help to identify children with ADHD whose symptoms are most likely to continue into adolescence.

AB - Importance: Attention-deficit/hyperactivity disorder (ADHD) is a heritable neurodevelopmental disorder that shows clinical and genetic overlap with other childhood neurodevelopmental disorders. Levels of ADHD symptoms typically decline across childhood and adolescence, although they remain elevated for some individuals. The determinants of symptom persistence and decline are not yet fully understood.Objectives: To test the hypothesis that genetic risk variant load for ADHD (indexed by polygenic risk scores [PRS]), but not for other psychiatric disorders, is associated with population-based ADHD symptom trajectories across childhood and adolescence, and to examine whether higher genetic liability for ADHD is correlated with total number of additional neurodevelopmental disorders (multimorbidity) in childhood.Design, Setting, and Participants: The Avon Longitudinal Study of Parents and Children, an ongoing prospective population-based cohort study, has been collecting data on 14 701 children, including 9757 with data on symptoms of ADHD at multiple time points, since September 6, 1990. The primary exposure variables, PRS, were generated using results of a genome-wide association study from the Psychiatric Genomics Consortium. Childhood multimorbidity scores (ages 7-9 years) were measured by total impairments in 4 domains known to share genetic liability with ADHD: IQ, social communication, pragmatic language, and conduct. Data analysis was conducted from March 1 to September 8, 2016.Main Outcomes and Measures: Attention-deficit/hyperactivity disorder symptom trajectories from ages 4 to 17 years (7 time points).Results: Among 9757 children with data on symptoms of ADHD at multiple time points (age range, 4-17 years; 4968 boys and 4789 girls), 4 ADHD symptom trajectories were identified: low (82.6%), intermediate (7.7%), childhood-limited (5.8%), and persistent (3.9%). Mean (SE) PRS for ADHD were higher in children in the persistent trajectory (0.254 [0.069]) compared with each of the other 3 trajectories (low, -0.018 [0.014], χ21 = 14.67, P < .001, odds ratio, 1.31; intermediate, 0.054 [0.055], χ21 = 4.70, P = .03, odds ratio, 1.22; and childhood-limited, 0.017 [0.060], χ21 = 6.50, P = .01, odds ratio, 1.27). Findings were specific to PRS for ADHD; PRS for other psychiatric conditions did not differ across trajectories. The proportion of children with multimorbidity was also highest in those in the persistent trajectory (42.5%; 95% CI, 33.9%-51.1%; P < .001) and was associated with persistence of ADHD symptoms independent of PRS.Conclusions and Relevance: Persistence of ADHD symptoms across childhood and adolescence in the general population is associated with higher PRS for ADHD. Childhood multimorbidity was also associated with persistence of ADHD symptoms and may help to identify children with ADHD whose symptoms are most likely to continue into adolescence.

U2 - 10.1001/jamapsychiatry.2016.2817

DO - 10.1001/jamapsychiatry.2016.2817

M3 - Journal article

C2 - 27806167

VL - 73

SP - 1285

EP - 1292

JO - J A M A Psychiatry

JF - J A M A Psychiatry

SN - 0003-990X

IS - 12

ER -