Department of Economics and Business Economics

Association of Genetic and Environmental Factors With Autism in a 5-Country Cohort

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Standard

Association of Genetic and Environmental Factors With Autism in a 5-Country Cohort. / Bai, Dan; Yip, Benjamin Hon Kei; Windham, Gayle C; Sourander, Andre; Francis, Richard; Yoffe, Rinat; Glasson, Emma; Mahjani, Behrang; Suominen, Auli; Leonard, Helen; Gissler, Mika; Buxbaum, Joseph D; Wong, Kingsley; Schendel, Diana; Kodesh, Arad; Breshnahan, Michaeline; Levine, Stephen Z; Parner, Erik T; Hansen, Stefan N; Hultman, Christina; Reichenberg, Abraham; Sandin, Sven.

In: JAMA Psychiatry, Vol. 76, No. 10, 2019, p. 1035-1043.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Bai, D, Yip, BHK, Windham, GC, Sourander, A, Francis, R, Yoffe, R, Glasson, E, Mahjani, B, Suominen, A, Leonard, H, Gissler, M, Buxbaum, JD, Wong, K, Schendel, D, Kodesh, A, Breshnahan, M, Levine, SZ, Parner, ET, Hansen, SN, Hultman, C, Reichenberg, A & Sandin, S 2019, 'Association of Genetic and Environmental Factors With Autism in a 5-Country Cohort', JAMA Psychiatry, vol. 76, no. 10, pp. 1035-1043. https://doi.org/10.1001/jamapsychiatry.2019.1411

APA

Bai, D., Yip, B. H. K., Windham, G. C., Sourander, A., Francis, R., Yoffe, R., Glasson, E., Mahjani, B., Suominen, A., Leonard, H., Gissler, M., Buxbaum, J. D., Wong, K., Schendel, D., Kodesh, A., Breshnahan, M., Levine, S. Z., Parner, E. T., Hansen, S. N., ... Sandin, S. (2019). Association of Genetic and Environmental Factors With Autism in a 5-Country Cohort. JAMA Psychiatry, 76(10), 1035-1043. https://doi.org/10.1001/jamapsychiatry.2019.1411

CBE

Bai D, Yip BHK, Windham GC, Sourander A, Francis R, Yoffe R, Glasson E, Mahjani B, Suominen A, Leonard H, Gissler M, Buxbaum JD, Wong K, Schendel D, Kodesh A, Breshnahan M, Levine SZ, Parner ET, Hansen SN, Hultman C, Reichenberg A, Sandin S. 2019. Association of Genetic and Environmental Factors With Autism in a 5-Country Cohort. JAMA Psychiatry. 76(10):1035-1043. https://doi.org/10.1001/jamapsychiatry.2019.1411

MLA

Vancouver

Bai D, Yip BHK, Windham GC, Sourander A, Francis R, Yoffe R et al. Association of Genetic and Environmental Factors With Autism in a 5-Country Cohort. JAMA Psychiatry. 2019;76(10):1035-1043. https://doi.org/10.1001/jamapsychiatry.2019.1411

Author

Bai, Dan ; Yip, Benjamin Hon Kei ; Windham, Gayle C ; Sourander, Andre ; Francis, Richard ; Yoffe, Rinat ; Glasson, Emma ; Mahjani, Behrang ; Suominen, Auli ; Leonard, Helen ; Gissler, Mika ; Buxbaum, Joseph D ; Wong, Kingsley ; Schendel, Diana ; Kodesh, Arad ; Breshnahan, Michaeline ; Levine, Stephen Z ; Parner, Erik T ; Hansen, Stefan N ; Hultman, Christina ; Reichenberg, Abraham ; Sandin, Sven. / Association of Genetic and Environmental Factors With Autism in a 5-Country Cohort. In: JAMA Psychiatry. 2019 ; Vol. 76, No. 10. pp. 1035-1043.

Bibtex

@article{421e9f77169b47d1bd55554da45bca01,
title = "Association of Genetic and Environmental Factors With Autism in a 5-Country Cohort",
abstract = "Importance: The origins and development of autism spectrum disorder (ASD) remain unresolved. No individual-level study has provided estimates of additive genetic, maternal, and environmental effects in ASD across several countries.Objective: To estimate the additive genetic, maternal, and environmental effects in ASD.Design, Setting, and Participants: Population-based, multinational cohort study including full birth cohorts of children from Denmark, Finland, Sweden, Israel, and Western Australia born between January 1, 1998, and December 31, 2011, and followed up to age 16 years. Data were analyzed from September 23, 2016 through February 4, 2018.Main Outcomes and Measures: Across 5 countries, models were fitted to estimate variance components describing the total variance in risk for ASD occurrence owing to additive genetics, maternal, and shared and nonshared environmental effects.Results: The analytic sample included 2 001 631 individuals, of whom 1 027 546 (51.3%) were male. Among the entire sample, 22 156 were diagnosed with ASD. The median (95% CI) ASD heritability was 80.8% (73.2%-85.5%) for country-specific point estimates, ranging from 50.9% (25.1%-75.6%) (Finland) to 86.8% (69.8%-100.0%) (Israel). For the Nordic countries combined, heritability estimates ranged from 81.2% (73.9%-85.3%) to 82.7% (79.1%-86.0%). Maternal effect was estimated to range from 0.4% to 1.6%. Estimates of genetic, maternal, and environmental effects for autistic disorder were similar with ASD.Conclusions and Relevance: Based on population data from 5 countries, the heritability of ASD was estimated to be approximately 80%, indicating that the variation in ASD occurrence in the population is mostly owing to inherited genetic influences, with no support for contribution from maternal effects. The results suggest possible modest differences in the sources of ASD risk between countries.",
author = "Dan Bai and Yip, {Benjamin Hon Kei} and Windham, {Gayle C} and Andre Sourander and Richard Francis and Rinat Yoffe and Emma Glasson and Behrang Mahjani and Auli Suominen and Helen Leonard and Mika Gissler and Buxbaum, {Joseph D} and Kingsley Wong and Diana Schendel and Arad Kodesh and Michaeline Breshnahan and Levine, {Stephen Z} and Parner, {Erik T} and Hansen, {Stefan N} and Christina Hultman and Abraham Reichenberg and Sven Sandin",
year = "2019",
doi = "10.1001/jamapsychiatry.2019.1411",
language = "English",
volume = "76",
pages = "1035--1043",
journal = "J A M A Psychiatry",
issn = "0003-990X",
publisher = "The JAMA Network",
number = "10",

}

RIS

TY - JOUR

T1 - Association of Genetic and Environmental Factors With Autism in a 5-Country Cohort

AU - Bai, Dan

AU - Yip, Benjamin Hon Kei

AU - Windham, Gayle C

AU - Sourander, Andre

AU - Francis, Richard

AU - Yoffe, Rinat

AU - Glasson, Emma

AU - Mahjani, Behrang

AU - Suominen, Auli

AU - Leonard, Helen

AU - Gissler, Mika

AU - Buxbaum, Joseph D

AU - Wong, Kingsley

AU - Schendel, Diana

AU - Kodesh, Arad

AU - Breshnahan, Michaeline

AU - Levine, Stephen Z

AU - Parner, Erik T

AU - Hansen, Stefan N

AU - Hultman, Christina

AU - Reichenberg, Abraham

AU - Sandin, Sven

PY - 2019

Y1 - 2019

N2 - Importance: The origins and development of autism spectrum disorder (ASD) remain unresolved. No individual-level study has provided estimates of additive genetic, maternal, and environmental effects in ASD across several countries.Objective: To estimate the additive genetic, maternal, and environmental effects in ASD.Design, Setting, and Participants: Population-based, multinational cohort study including full birth cohorts of children from Denmark, Finland, Sweden, Israel, and Western Australia born between January 1, 1998, and December 31, 2011, and followed up to age 16 years. Data were analyzed from September 23, 2016 through February 4, 2018.Main Outcomes and Measures: Across 5 countries, models were fitted to estimate variance components describing the total variance in risk for ASD occurrence owing to additive genetics, maternal, and shared and nonshared environmental effects.Results: The analytic sample included 2 001 631 individuals, of whom 1 027 546 (51.3%) were male. Among the entire sample, 22 156 were diagnosed with ASD. The median (95% CI) ASD heritability was 80.8% (73.2%-85.5%) for country-specific point estimates, ranging from 50.9% (25.1%-75.6%) (Finland) to 86.8% (69.8%-100.0%) (Israel). For the Nordic countries combined, heritability estimates ranged from 81.2% (73.9%-85.3%) to 82.7% (79.1%-86.0%). Maternal effect was estimated to range from 0.4% to 1.6%. Estimates of genetic, maternal, and environmental effects for autistic disorder were similar with ASD.Conclusions and Relevance: Based on population data from 5 countries, the heritability of ASD was estimated to be approximately 80%, indicating that the variation in ASD occurrence in the population is mostly owing to inherited genetic influences, with no support for contribution from maternal effects. The results suggest possible modest differences in the sources of ASD risk between countries.

AB - Importance: The origins and development of autism spectrum disorder (ASD) remain unresolved. No individual-level study has provided estimates of additive genetic, maternal, and environmental effects in ASD across several countries.Objective: To estimate the additive genetic, maternal, and environmental effects in ASD.Design, Setting, and Participants: Population-based, multinational cohort study including full birth cohorts of children from Denmark, Finland, Sweden, Israel, and Western Australia born between January 1, 1998, and December 31, 2011, and followed up to age 16 years. Data were analyzed from September 23, 2016 through February 4, 2018.Main Outcomes and Measures: Across 5 countries, models were fitted to estimate variance components describing the total variance in risk for ASD occurrence owing to additive genetics, maternal, and shared and nonshared environmental effects.Results: The analytic sample included 2 001 631 individuals, of whom 1 027 546 (51.3%) were male. Among the entire sample, 22 156 were diagnosed with ASD. The median (95% CI) ASD heritability was 80.8% (73.2%-85.5%) for country-specific point estimates, ranging from 50.9% (25.1%-75.6%) (Finland) to 86.8% (69.8%-100.0%) (Israel). For the Nordic countries combined, heritability estimates ranged from 81.2% (73.9%-85.3%) to 82.7% (79.1%-86.0%). Maternal effect was estimated to range from 0.4% to 1.6%. Estimates of genetic, maternal, and environmental effects for autistic disorder were similar with ASD.Conclusions and Relevance: Based on population data from 5 countries, the heritability of ASD was estimated to be approximately 80%, indicating that the variation in ASD occurrence in the population is mostly owing to inherited genetic influences, with no support for contribution from maternal effects. The results suggest possible modest differences in the sources of ASD risk between countries.

UR - http://www.scopus.com/inward/record.url?scp=85069447745&partnerID=8YFLogxK

U2 - 10.1001/jamapsychiatry.2019.1411

DO - 10.1001/jamapsychiatry.2019.1411

M3 - Journal article

C2 - 31314057

VL - 76

SP - 1035

EP - 1043

JO - J A M A Psychiatry

JF - J A M A Psychiatry

SN - 0003-990X

IS - 10

ER -