Association of abnormal cerebellar activation with motor learning difficulties in dyslexic adults

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • Roderick I. Nicolson, University of Sheffield, Sheffield
  • ,
  • Angela J. Fawcett, University of Sheffield, Sheffield
  • ,
  • Emma L. Berry, University of Sheffield, Sheffield
  • ,
  • I. Harri Jenkins, Hammersmith Hospital
  • ,
  • Paul Dean, University of Sheffield, Sheffield
  • ,
  • David J. Brooks

Background. In addition to their impairments in literacy-related skills, dyslexic children show characteristic difficulties in phonological skill, motor skill, and balance. There is behavioural and biochemical evidence that these difficulties may be attributable to mild cerebellar dysfunction. We wanted to find out whether there was abnormal brain activation when dyslexic adults undertook tasks known normally to involve cerebellar activation. Methods. Brain activation was monitored by positron emission tomography in matched groups of six dyslexic adults and six control adults as they carried out either a prelearned sequence or learned a novel sequence of finger movements. Findings. Brain activation was significantly lower (p < 0.01) for the dyslexic adults than for the controls in the right cerebellar cortex and the left cingulate gyrus when executing the prelearned sequence, and in the right cerebellar cortex when learning the new sequence. Interpretation. The results provided direct evidence that, for this group of dyslexic adults, the behavioural signs of cerebellar abnormality reflect underlying abnormalities in cerebellar activation.

Original languageEnglish
JournalLancet
Volume353
Issue9165
Pages (from-to)1662-1667
Number of pages6
ISSN0140-6736
DOIs
Publication statusPublished - 15 May 1999
Externally publishedYes

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