Association mapping and disease: Evolutionary perspectives

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In this chapter, we give a short introduction to the genetics of complex diseases emphasizing evolutionary models for disease genes and the effect of different models on the genetic architecture, and we give a survey of the state-of-the-art of genome-wide association studies (GWASs).

Original languageEnglish
Title of host publicationEvolutionary genomics : Statistical and computational methods
EditorsMaria Anisimova
Number of pages21
PublisherSpringer
Publication year2019
Edition2
Pages533-553
Chapter17
ISBN (print) 978-1-4939-9073-3
ISBN (Electronic)978-1-4939-9074-0
DOIs
Publication statusPublished - 2019
SeriesMethods in Molecular Biology
Volume1910
ISSN1064-3745

    Research areas

  • Association mapping, Common disease/common variant, Complex diseases, Genome-wide association studies

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