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Association between Single Nucleotide Polymorphisms in Cardiovascular Developmental Critical Genes and Hypertension: A Propensity Score Matching Analysis

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Association between Single Nucleotide Polymorphisms in Cardiovascular Developmental Critical Genes and Hypertension : A Propensity Score Matching Analysis. / Zhao, Zhiqiang; Gong, Chunmei; Gao, Yanfang; Liu, Xiaoli; Wu, Sai; Zhao, Heping; Wang, Xiaohui; Liu, Huaixiang; Xiao, Chen; Liu, Jieyi; Li, Jiong; He, Yun.

In: International Journal of Hypertension, Vol. 2020, 9185697, 01.2020.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Zhao, Z, Gong, C, Gao, Y, Liu, X, Wu, S, Zhao, H, Wang, X, Liu, H, Xiao, C, Liu, J, Li, J & He, Y 2020, 'Association between Single Nucleotide Polymorphisms in Cardiovascular Developmental Critical Genes and Hypertension: A Propensity Score Matching Analysis', International Journal of Hypertension, vol. 2020, 9185697. https://doi.org/10.1155/2020/9185697

APA

Zhao, Z., Gong, C., Gao, Y., Liu, X., Wu, S., Zhao, H., Wang, X., Liu, H., Xiao, C., Liu, J., Li, J., & He, Y. (2020). Association between Single Nucleotide Polymorphisms in Cardiovascular Developmental Critical Genes and Hypertension: A Propensity Score Matching Analysis. International Journal of Hypertension, 2020, [9185697]. https://doi.org/10.1155/2020/9185697

CBE

Zhao Z, Gong C, Gao Y, Liu X, Wu S, Zhao H, Wang X, Liu H, Xiao C, Liu J, Li J, He Y. 2020. Association between Single Nucleotide Polymorphisms in Cardiovascular Developmental Critical Genes and Hypertension: A Propensity Score Matching Analysis. International Journal of Hypertension. 2020:Article 9185697. https://doi.org/10.1155/2020/9185697

MLA

Vancouver

Author

Zhao, Zhiqiang ; Gong, Chunmei ; Gao, Yanfang ; Liu, Xiaoli ; Wu, Sai ; Zhao, Heping ; Wang, Xiaohui ; Liu, Huaixiang ; Xiao, Chen ; Liu, Jieyi ; Li, Jiong ; He, Yun. / Association between Single Nucleotide Polymorphisms in Cardiovascular Developmental Critical Genes and Hypertension : A Propensity Score Matching Analysis. In: International Journal of Hypertension. 2020 ; Vol. 2020.

Bibtex

@article{e80f5c06bd244ecb801afceb62567caa,
title = "Association between Single Nucleotide Polymorphisms in Cardiovascular Developmental Critical Genes and Hypertension: A Propensity Score Matching Analysis",
abstract = "Cardiovascular development critical genes are key determinants in cardiovascular diseases. We hypothesize that SNPs in these genes may play critical roles in the development of hypertension. Therefore, we enrolled 516 paired hypertension patients and controls in a total of 2,742 subjects in a cross-sectional population study by the propensity score matching (PSM) method. Twenty-one SNPs from 5 cardiovascular developmental related genes were detected by the improved multiplex ligase detection reaction (iMLDR) method. Conditioned logistic regression under three different genetic models, namely, additive model, dominant model, and recessive model, was performed. The odds ratio (ORs) and 95% confidence intervals (95% CIs) were used to estimate the associations of SNPs with hypertension. We found that the distribution of genotypes at rs833061, rs3025010, and rs699947 within the VEGFA gene and the distribution of alleles at rs3025010 in hypertension subjects were different from those in controls. Both rs833061 and rs3025010 were associated with hypertension in crude models, but only rs3025010 remains associated with hypertension after adjusting with confounding factors in the additive model and the dominant model. We also found that hypertension subjects with C/T and C/C genotypes at rs3025010 had lower SBP and DBP levels. In addition, rs3025010 could interact with rs6784267 within the CCM3 gene in the association. In conclusion, our findings suggest that rs3025010 may play a role in the pathogenesis of hypertension, which may be a potential target for individualized prevention and treatment of hypertension.",
author = "Zhiqiang Zhao and Chunmei Gong and Yanfang Gao and Xiaoli Liu and Sai Wu and Heping Zhao and Xiaohui Wang and Huaixiang Liu and Chen Xiao and Jieyi Liu and Jiong Li and Yun He",
year = "2020",
month = jan,
doi = "10.1155/2020/9185697",
language = "English",
volume = "2020",
journal = "International Journal of Hypertension",
issn = "2090-0384",
publisher = "Hindawi Publishing Corporation",

}

RIS

TY - JOUR

T1 - Association between Single Nucleotide Polymorphisms in Cardiovascular Developmental Critical Genes and Hypertension

T2 - A Propensity Score Matching Analysis

AU - Zhao, Zhiqiang

AU - Gong, Chunmei

AU - Gao, Yanfang

AU - Liu, Xiaoli

AU - Wu, Sai

AU - Zhao, Heping

AU - Wang, Xiaohui

AU - Liu, Huaixiang

AU - Xiao, Chen

AU - Liu, Jieyi

AU - Li, Jiong

AU - He, Yun

PY - 2020/1

Y1 - 2020/1

N2 - Cardiovascular development critical genes are key determinants in cardiovascular diseases. We hypothesize that SNPs in these genes may play critical roles in the development of hypertension. Therefore, we enrolled 516 paired hypertension patients and controls in a total of 2,742 subjects in a cross-sectional population study by the propensity score matching (PSM) method. Twenty-one SNPs from 5 cardiovascular developmental related genes were detected by the improved multiplex ligase detection reaction (iMLDR) method. Conditioned logistic regression under three different genetic models, namely, additive model, dominant model, and recessive model, was performed. The odds ratio (ORs) and 95% confidence intervals (95% CIs) were used to estimate the associations of SNPs with hypertension. We found that the distribution of genotypes at rs833061, rs3025010, and rs699947 within the VEGFA gene and the distribution of alleles at rs3025010 in hypertension subjects were different from those in controls. Both rs833061 and rs3025010 were associated with hypertension in crude models, but only rs3025010 remains associated with hypertension after adjusting with confounding factors in the additive model and the dominant model. We also found that hypertension subjects with C/T and C/C genotypes at rs3025010 had lower SBP and DBP levels. In addition, rs3025010 could interact with rs6784267 within the CCM3 gene in the association. In conclusion, our findings suggest that rs3025010 may play a role in the pathogenesis of hypertension, which may be a potential target for individualized prevention and treatment of hypertension.

AB - Cardiovascular development critical genes are key determinants in cardiovascular diseases. We hypothesize that SNPs in these genes may play critical roles in the development of hypertension. Therefore, we enrolled 516 paired hypertension patients and controls in a total of 2,742 subjects in a cross-sectional population study by the propensity score matching (PSM) method. Twenty-one SNPs from 5 cardiovascular developmental related genes were detected by the improved multiplex ligase detection reaction (iMLDR) method. Conditioned logistic regression under three different genetic models, namely, additive model, dominant model, and recessive model, was performed. The odds ratio (ORs) and 95% confidence intervals (95% CIs) were used to estimate the associations of SNPs with hypertension. We found that the distribution of genotypes at rs833061, rs3025010, and rs699947 within the VEGFA gene and the distribution of alleles at rs3025010 in hypertension subjects were different from those in controls. Both rs833061 and rs3025010 were associated with hypertension in crude models, but only rs3025010 remains associated with hypertension after adjusting with confounding factors in the additive model and the dominant model. We also found that hypertension subjects with C/T and C/C genotypes at rs3025010 had lower SBP and DBP levels. In addition, rs3025010 could interact with rs6784267 within the CCM3 gene in the association. In conclusion, our findings suggest that rs3025010 may play a role in the pathogenesis of hypertension, which may be a potential target for individualized prevention and treatment of hypertension.

UR - http://www.scopus.com/inward/record.url?scp=85082764486&partnerID=8YFLogxK

U2 - 10.1155/2020/9185697

DO - 10.1155/2020/9185697

M3 - Journal article

C2 - 32257424

AN - SCOPUS:85082764486

VL - 2020

JO - International Journal of Hypertension

JF - International Journal of Hypertension

SN - 2090-0384

M1 - 9185697

ER -