Association between interleukin-15 and obesity: Interleukin-15 as a potential regulator of fat mass

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DOI

  • Anders Rinnov Nielsen, University of Copenhagen, Centre of Inflammation and Metabolism, Rigshospitalet
  • ,
  • Pernille Hojman, University of Copenhagen, Amtssygehuset i Herlev
  • ,
  • Christian Erikstrup
  • Christian Philip Fischer, University of Copenhagen, Centre of Inflammation and Metabolism
  • ,
  • Peter Plomgaard, University of Copenhagen
  • ,
  • Remi Mounier, University of Copenhagen
  • ,
  • Ole Hartvig Mortensen
  • Christa Broholm, University of Copenhagen
  • ,
  • Sarah Taudorf, University of Copenhagen
  • ,
  • Rikke Krogh-Madsen, University of Copenhagen
  • ,
  • Birgitte Lindegaard, University of Copenhagen
  • ,
  • Anne Marie Winther Petersen, University of Copenhagen, Centre of Inflammation and Metabolism
  • ,
  • Julie Gehl, Amtssygehuset i Herlev
  • ,
  • Bente Klarlund Pedersen, University of Copenhagen, Centre of Inflammation and Metabolism

Objective: IL-15 decreases lipid deposition in preadipocytes and decreases the mass of white adipose tissue in rats, indicating that IL-15 may take part in regulating this tissue. IL-15 is expressed in human skeletal muscle and skeletal muscle may be a source of plasma IL-15 and in this way regulate adipose tissue mass. Design: The relation between skeletal muscle IL-15 mRNA expression, plasma IL-15, and adipose tissue mass was studied in 199 humans divided into four groups on the basis of obesity and type 2 diabetes. Furthermore, using a DNA electrotransfer model, we assessed the effect of IL-15 overexpression in skeletal muscle of mice. Results: In humans, multiple regression analysis showed a negative association between plasma IL-15 and total fat mass (P < 0.05), trunk fat mass (P < 0.01), and percent fat mass (P < 0.05), independent of type 2 diabetes. Negative associations were also found between muscle IL-15 mRNA and obesity parameters. IL-15 overexpression in skeletal muscle of mice reduced trunk fat mass but not sc fat mass. Conclusions: Our results indicate that IL-15 may be a regulator of trunk fat mass.

Original languageEnglish
JournalJournal of Clinical Endocrinology and Metabolism
Volume93
Issue11
Pages (from-to)4486-4493
Number of pages8
ISSN0021-972X
DOIs
Publication statusPublished - 1 Jan 2008
Externally publishedYes

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