Association between abdominal and general obesity and respiratory symptoms, asthma and COPD: Results from the RHINE study

Marta A. Kisiel; Oscar Arnfelt; Eva Lindberg; Oscar Jogi; Andrei Malinovschi; Ane Johannessen; Bryndis Benediktsdottir; Karl Franklin; Mathias Holm; Francisco Gomez Real; Torben Sigsgaard; Thorarinn Gislason; Lars Modig; Christer Janson

doi:10.1016/j.rmed.2023.107213

Association between abdominal and general obesity and respiratory symptoms, asthma and COPD: Results from the RHINE study

Marta A. Kisiel^*, Oscar Arnfelt, Eva Lindberg, Oscar Jogi, Andrei Malinovschi, Ane Johannessen, Bryndis Benediktsdottir, Karl Franklin, Mathias Holm, Francisco Gomez Real, Torben Sigsgaard, Thorarinn Gislason, Lars Modig, Christer Janson

^*Corresponding author for this work

Department of Public Health - Institute of Environmental and Occupational Medicine

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Abstract

Introduction: Previous studies on the association between abdominal and general obesity and respiratory disease have provided conflicting results. Aims and objectives: We aimed to explore the associations of abdominal obesity with respiratory symptoms, asthma, and chronic obstructive pulmonary disease independently from general obesity in women and men. Methods: This cross-sectional study was based on the Respiratory Health in Northern Europe (RHINE) III questionnaire (n = 12 290) conducted in 2010–2012. Abdominal obesity was self-measured waist circumference using a sex-specific standard cut-off point: ≥102 cm in males and ≥88 cm in females. General obesity was defined as self-reported BMI ≥30.0 kg/m². Results: There were 4261 subjects (63% women) with abdominal obesity and 1837 subjects (50% women) with general obesity. Both abdominal and general obesity was independent of each other and associated with respiratory symptoms (odds ratio (OR) from 1.25 to 2.00)). Asthma was significantly associated with abdominal and general obesity in women, OR (95% CI) 1.56 (1.30–1.87) and 1.95 (1.56–2.43), respectively, but not in men, OR 1.22 (0.97–3.17) and 1.28 (0.97–1.68) respectively. A similar sex difference was found for self-reported chronic obstructive pulmonary disease. Conclusions: General and abdominal obesity were independent factors associated with respiratory symptoms in adults. Asthma and chronic obstructive pulmonary disease were independently linked to abdominal and general obesity in women but not men.

Original language	English
Article number	107213
Journal	Respiratory Medicine
Volume	211
ISSN	0954-6111
DOIs	https://doi.org/10.1016/j.rmed.2023.107213
Publication status	Published - May 2023

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Association between abdominal and general obesity and respiratory symptoms, asthma and COPD. Results from the RHINE studyFinal published version, 1 MBLicence: CC BY

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Kisiel, M. A., Arnfelt, O., Lindberg, E., Jogi, O., Malinovschi, A., Johannessen, A., Benediktsdottir, B., Franklin, K., Holm, M., Real, F. G., Sigsgaard, T., Gislason, T., Modig, L., & Janson, C. (2023). Association between abdominal and general obesity and respiratory symptoms, asthma and COPD: Results from the RHINE study. Respiratory Medicine, 211, Article 107213. https://doi.org/10.1016/j.rmed.2023.107213

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title = "Association between abdominal and general obesity and respiratory symptoms, asthma and COPD: Results from the RHINE study",

abstract = "Introduction: Previous studies on the association between abdominal and general obesity and respiratory disease have provided conflicting results. Aims and objectives: We aimed to explore the associations of abdominal obesity with respiratory symptoms, asthma, and chronic obstructive pulmonary disease independently from general obesity in women and men. Methods: This cross-sectional study was based on the Respiratory Health in Northern Europe (RHINE) III questionnaire (n = 12 290) conducted in 2010–2012. Abdominal obesity was self-measured waist circumference using a sex-specific standard cut-off point: ≥102 cm in males and ≥88 cm in females. General obesity was defined as self-reported BMI ≥30.0 kg/m2. Results: There were 4261 subjects (63% women) with abdominal obesity and 1837 subjects (50% women) with general obesity. Both abdominal and general obesity was independent of each other and associated with respiratory symptoms (odds ratio (OR) from 1.25 to 2.00)). Asthma was significantly associated with abdominal and general obesity in women, OR (95% CI) 1.56 (1.30–1.87) and 1.95 (1.56–2.43), respectively, but not in men, OR 1.22 (0.97–3.17) and 1.28 (0.97–1.68) respectively. A similar sex difference was found for self-reported chronic obstructive pulmonary disease. Conclusions: General and abdominal obesity were independent factors associated with respiratory symptoms in adults. Asthma and chronic obstructive pulmonary disease were independently linked to abdominal and general obesity in women but not men.",

author = "Kisiel, {Marta A.} and Oscar Arnfelt and Eva Lindberg and Oscar Jogi and Andrei Malinovschi and Ane Johannessen and Bryndis Benediktsdottir and Karl Franklin and Mathias Holm and Real, {Francisco Gomez} and Torben Sigsgaard and Thorarinn Gislason and Lars Modig and Christer Janson",

year = "2023",

month = may,

doi = "10.1016/j.rmed.2023.107213",

language = "English",

volume = "211",

journal = "Respiratory Medicine",

issn = "0954-6111",

publisher = "W.B. Saunders Ltd",

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Kisiel, MA, Arnfelt, O, Lindberg, E, Jogi, O, Malinovschi, A, Johannessen, A, Benediktsdottir, B, Franklin, K, Holm, M, Real, FG, Sigsgaard, T, Gislason, T, Modig, L & Janson, C 2023, 'Association between abdominal and general obesity and respiratory symptoms, asthma and COPD: Results from the RHINE study', Respiratory Medicine, vol. 211, 107213. https://doi.org/10.1016/j.rmed.2023.107213

Association between abdominal and general obesity and respiratory symptoms, asthma and COPD: Results from the RHINE study. / Kisiel, Marta A.; Arnfelt, Oscar; Lindberg, Eva et al.
In: Respiratory Medicine, Vol. 211, 107213, 05.2023.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

TY - JOUR

T1 - Association between abdominal and general obesity and respiratory symptoms, asthma and COPD

T2 - Results from the RHINE study

AU - Kisiel, Marta A.

AU - Arnfelt, Oscar

AU - Lindberg, Eva

AU - Jogi, Oscar

AU - Malinovschi, Andrei

AU - Johannessen, Ane

AU - Benediktsdottir, Bryndis

AU - Franklin, Karl

AU - Holm, Mathias

AU - Real, Francisco Gomez

AU - Sigsgaard, Torben

AU - Gislason, Thorarinn

AU - Modig, Lars

AU - Janson, Christer

PY - 2023/5

Y1 - 2023/5

N2 - Introduction: Previous studies on the association between abdominal and general obesity and respiratory disease have provided conflicting results. Aims and objectives: We aimed to explore the associations of abdominal obesity with respiratory symptoms, asthma, and chronic obstructive pulmonary disease independently from general obesity in women and men. Methods: This cross-sectional study was based on the Respiratory Health in Northern Europe (RHINE) III questionnaire (n = 12 290) conducted in 2010–2012. Abdominal obesity was self-measured waist circumference using a sex-specific standard cut-off point: ≥102 cm in males and ≥88 cm in females. General obesity was defined as self-reported BMI ≥30.0 kg/m2. Results: There were 4261 subjects (63% women) with abdominal obesity and 1837 subjects (50% women) with general obesity. Both abdominal and general obesity was independent of each other and associated with respiratory symptoms (odds ratio (OR) from 1.25 to 2.00)). Asthma was significantly associated with abdominal and general obesity in women, OR (95% CI) 1.56 (1.30–1.87) and 1.95 (1.56–2.43), respectively, but not in men, OR 1.22 (0.97–3.17) and 1.28 (0.97–1.68) respectively. A similar sex difference was found for self-reported chronic obstructive pulmonary disease. Conclusions: General and abdominal obesity were independent factors associated with respiratory symptoms in adults. Asthma and chronic obstructive pulmonary disease were independently linked to abdominal and general obesity in women but not men.

AB - Introduction: Previous studies on the association between abdominal and general obesity and respiratory disease have provided conflicting results. Aims and objectives: We aimed to explore the associations of abdominal obesity with respiratory symptoms, asthma, and chronic obstructive pulmonary disease independently from general obesity in women and men. Methods: This cross-sectional study was based on the Respiratory Health in Northern Europe (RHINE) III questionnaire (n = 12 290) conducted in 2010–2012. Abdominal obesity was self-measured waist circumference using a sex-specific standard cut-off point: ≥102 cm in males and ≥88 cm in females. General obesity was defined as self-reported BMI ≥30.0 kg/m2. Results: There were 4261 subjects (63% women) with abdominal obesity and 1837 subjects (50% women) with general obesity. Both abdominal and general obesity was independent of each other and associated with respiratory symptoms (odds ratio (OR) from 1.25 to 2.00)). Asthma was significantly associated with abdominal and general obesity in women, OR (95% CI) 1.56 (1.30–1.87) and 1.95 (1.56–2.43), respectively, but not in men, OR 1.22 (0.97–3.17) and 1.28 (0.97–1.68) respectively. A similar sex difference was found for self-reported chronic obstructive pulmonary disease. Conclusions: General and abdominal obesity were independent factors associated with respiratory symptoms in adults. Asthma and chronic obstructive pulmonary disease were independently linked to abdominal and general obesity in women but not men.

UR - http://www.scopus.com/inward/record.url?scp=85150384769&partnerID=8YFLogxK

U2 - 10.1016/j.rmed.2023.107213

DO - 10.1016/j.rmed.2023.107213

M3 - Journal article

C2 - 36933674

AN - SCOPUS:85150384769

SN - 0954-6111

VL - 211

JO - Respiratory Medicine

JF - Respiratory Medicine

M1 - 107213

ER -

Association between abdominal and general obesity and respiratory symptoms, asthma and COPD: Results from the RHINE study

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