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Abstract
Genome-wide association testing facilitates the identification of genetic variants associated with complex traits. Mapping genes that promote genetic resistance to mastitis could reduce the cost of antibiotic use and enhance animal welfare and milk production by improving outcomes of breeding for udder health. Using imputed whole-genome sequence variants, we carried out association studies for 2 traits related to udder health, udder index, and milking speed in Nordic Holstein cattle. A total of 4,921 bulls genotyped with the BovineSNP50 BeadChip array were imputed to high-density genotypes (Illumina BovineHD BeadChip, Illumina, San Diego, CA) and, subsequently, to whole-genome sequence variants. An association analysis was carried out using a linear mixed model. Phenotypes used in the association analyses were deregressed breeding values. Multitrait meta-analysis was carried out for these 2 traits. We identified 10 and 8 chromosomes harboring markers that were significantly associated with udder index and milking speed, respectively. Strongest association signals were observed on chromosome 20 for udder index and chromosome 19 for milking speed. Multitrait meta-analysis identified 13 chromosomes harboring associated markers for the combination of udder index and milking speed. The associated region on chromosome 20 overlapped with earlier reported quantitative trait loci for similar traits in other cattle populations. Moreover, this region was located close to the FYB gene, which is involved in platelet activation and controls IL-2 expression; FYB is a strong candidate gene for udder health and worthy of further investigation.
| Original language | English |
|---|---|
| Journal | Journal of Dairy Science |
| Volume | 101 |
| Issue | 3 |
| Pages (from-to) | 2199-2212 |
| Number of pages | 14 |
| ISSN | 0022-0302 |
| DOIs | |
| Publication status | Published - Mar 2018 |
Keywords
- genome-wide association study
- milking speed
- udder conformation
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GenSAP : GenSAP - Center for Genomic Selection in Animal and Plants
Lund, M. S. (Project manager), Sørensen, P. (Project manager), Janss, L. (Project manager), Sørensen, A. C. (Project manager), Dybdahl Pedersen, L. (Project coordinator), Jensen, J. (Participant), Christensen, O. F. (Participant), Guldbrandtsen, B. (Participant), Asp, T. (Participant), Bendixen, C. (Participant), Su, G. (Participant), Madsen, P. (Participant), Brøndum, R. F. (Participant), Rasmussen, S. K. (Participant), Nielsen, K. L. (Participant), Goddard, M. (Participant), Meuwissen, T. (Participant), Mackay, T. (Participant), Boichard, D. (Participant), Zhang, Q. (Participant) & Gianola, D. (Participant)
Det Strategiske Forskningsråd, Programkomiteen for Sunhed, fødevarer og velfærd
01/01/2013 → 31/12/2018
Project: Research