Assessment of Somatosensory and Psychosocial Function of Patients with Trigeminal Nerve Damage

Rajath Sasidharan Pillai; Maria Pigg; Thomas List; Pall Karlsson; Živko Mladenović; Lene Vase; Sven Erik Nørholt; Thomas Klit Pedersen; Martin Bengtsson; Yuri Martins Costa; Peter Svensson; Lene Baad-Hansen

doi:10.1097/AJP.0000000000000806

Assessment of Somatosensory and Psychosocial Function of Patients with Trigeminal Nerve Damage

Rajath Sasidharan Pillai, Maria Pigg, Thomas List, Pall Karlsson, Živko Mladenović, Lene Vase, Sven Erik Nørholt, Thomas Klit Pedersen, Martin Bengtsson, Yuri Martins Costa, Peter Svensson, Lene Baad-Hansen

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

11 Citations (Scopus)

Abstract

Objective:The present study assessed somatosensory changes related to trigeminal nerve damage using extensive evaluation tools and assessed the effect of such damage on the patients' psychosocial status and quality of life compared with healthy participants.Methods:In 37 patients with intraorally or extraorally presenting trigeminal nerve damage diagnosed as painful or nonpainful posttraumatic trigeminal neuropathy, psychophysical tests like quantitative sensory testing (QST) and qualitative sensory testing and the electrophysiological "nociceptive-specific" blink reflex were performed. The patients and 20 healthy participants completed a set of questionnaires assessing their psychosocial status and quality of life.Results:A loss or gain of somatosensory function was seen in at least 1 QST parameter in >88.9% of the patients. Patients in whom extraoral QST was performed showed an overall loss of somatosensory function, whereas intraoral QST showed a general gain of somatosensory function. Qualitative sensory testing identified a side-to-side difference in the tactile and pinprick stimulation in >77% of the patients. An abnormal "nociceptive-specific" blink reflex response was seen in 42.1% to 71.4% of patients dependent on the trigeminal branch stimulated, though comparisons with healthy reference values showed ambiguous results. Compared with the healthy participants, patients showed higher scores for pain catastrophizing, symptoms of depression and anxiety, limited jaw function, more somatic symptoms, and significantly impaired oral health-related quality of life (all P<0.038).Discussion:The results from the present study showed presence of varied somatosensory abnormalities when assessed using psychophysical and electrophysiological investigations and a significantly impaired psychosocial status.

Original language	English
Journal	The Clinical Journal of Pain
Volume	36
Issue	5
Pages (from-to)	321-335
Number of pages	15
ISSN	0749-8047
DOIs	https://doi.org/10.1097/AJP.0000000000000806
Publication status	Published - 1 May 2020

Keywords

Key Words:
blink reflex
quality of life
quantitative sensory testing
trigeminal neuropathy

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title = "Assessment of Somatosensory and Psychosocial Function of Patients with Trigeminal Nerve Damage",

abstract = "Objective:The present study assessed somatosensory changes related to trigeminal nerve damage using extensive evaluation tools and assessed the effect of such damage on the patients' psychosocial status and quality of life compared with healthy participants.Methods:In 37 patients with intraorally or extraorally presenting trigeminal nerve damage diagnosed as painful or nonpainful posttraumatic trigeminal neuropathy, psychophysical tests like quantitative sensory testing (QST) and qualitative sensory testing and the electrophysiological {"}nociceptive-specific{"} blink reflex were performed. The patients and 20 healthy participants completed a set of questionnaires assessing their psychosocial status and quality of life.Results:A loss or gain of somatosensory function was seen in at least 1 QST parameter in >88.9% of the patients. Patients in whom extraoral QST was performed showed an overall loss of somatosensory function, whereas intraoral QST showed a general gain of somatosensory function. Qualitative sensory testing identified a side-to-side difference in the tactile and pinprick stimulation in >77% of the patients. An abnormal {"}nociceptive-specific{"} blink reflex response was seen in 42.1% to 71.4% of patients dependent on the trigeminal branch stimulated, though comparisons with healthy reference values showed ambiguous results. Compared with the healthy participants, patients showed higher scores for pain catastrophizing, symptoms of depression and anxiety, limited jaw function, more somatic symptoms, and significantly impaired oral health-related quality of life (all P<0.038).Discussion:The results from the present study showed presence of varied somatosensory abnormalities when assessed using psychophysical and electrophysiological investigations and a significantly impaired psychosocial status.",

keywords = "Key Words:, blink reflex, quality of life, quantitative sensory testing, trigeminal neuropathy",

author = "Pillai, {Rajath Sasidharan} and Maria Pigg and Thomas List and Pall Karlsson and {\v Z}ivko Mladenovi{\'c} and Lene Vase and N{\o}rholt, {Sven Erik} and Pedersen, {Thomas Klit} and Martin Bengtsson and Costa, {Yuri Martins} and Peter Svensson and Lene Baad-Hansen",

year = "2020",

month = may,

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Assessment of Somatosensory and Psychosocial Function of Patients with Trigeminal Nerve Damage. / Pillai, Rajath Sasidharan; Pigg, Maria; List, Thomas et al.
In: The Clinical Journal of Pain, Vol. 36, No. 5, 01.05.2020, p. 321-335.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

TY - JOUR

T1 - Assessment of Somatosensory and Psychosocial Function of Patients with Trigeminal Nerve Damage

AU - Pillai, Rajath Sasidharan

AU - Pigg, Maria

AU - List, Thomas

AU - Karlsson, Pall

AU - Mladenović, Živko

AU - Vase, Lene

AU - Nørholt, Sven Erik

AU - Pedersen, Thomas Klit

AU - Bengtsson, Martin

AU - Costa, Yuri Martins

AU - Svensson, Peter

AU - Baad-Hansen, Lene

PY - 2020/5/1

Y1 - 2020/5/1

N2 - Objective:The present study assessed somatosensory changes related to trigeminal nerve damage using extensive evaluation tools and assessed the effect of such damage on the patients' psychosocial status and quality of life compared with healthy participants.Methods:In 37 patients with intraorally or extraorally presenting trigeminal nerve damage diagnosed as painful or nonpainful posttraumatic trigeminal neuropathy, psychophysical tests like quantitative sensory testing (QST) and qualitative sensory testing and the electrophysiological "nociceptive-specific" blink reflex were performed. The patients and 20 healthy participants completed a set of questionnaires assessing their psychosocial status and quality of life.Results:A loss or gain of somatosensory function was seen in at least 1 QST parameter in >88.9% of the patients. Patients in whom extraoral QST was performed showed an overall loss of somatosensory function, whereas intraoral QST showed a general gain of somatosensory function. Qualitative sensory testing identified a side-to-side difference in the tactile and pinprick stimulation in >77% of the patients. An abnormal "nociceptive-specific" blink reflex response was seen in 42.1% to 71.4% of patients dependent on the trigeminal branch stimulated, though comparisons with healthy reference values showed ambiguous results. Compared with the healthy participants, patients showed higher scores for pain catastrophizing, symptoms of depression and anxiety, limited jaw function, more somatic symptoms, and significantly impaired oral health-related quality of life (all P<0.038).Discussion:The results from the present study showed presence of varied somatosensory abnormalities when assessed using psychophysical and electrophysiological investigations and a significantly impaired psychosocial status.

AB - Objective:The present study assessed somatosensory changes related to trigeminal nerve damage using extensive evaluation tools and assessed the effect of such damage on the patients' psychosocial status and quality of life compared with healthy participants.Methods:In 37 patients with intraorally or extraorally presenting trigeminal nerve damage diagnosed as painful or nonpainful posttraumatic trigeminal neuropathy, psychophysical tests like quantitative sensory testing (QST) and qualitative sensory testing and the electrophysiological "nociceptive-specific" blink reflex were performed. The patients and 20 healthy participants completed a set of questionnaires assessing their psychosocial status and quality of life.Results:A loss or gain of somatosensory function was seen in at least 1 QST parameter in >88.9% of the patients. Patients in whom extraoral QST was performed showed an overall loss of somatosensory function, whereas intraoral QST showed a general gain of somatosensory function. Qualitative sensory testing identified a side-to-side difference in the tactile and pinprick stimulation in >77% of the patients. An abnormal "nociceptive-specific" blink reflex response was seen in 42.1% to 71.4% of patients dependent on the trigeminal branch stimulated, though comparisons with healthy reference values showed ambiguous results. Compared with the healthy participants, patients showed higher scores for pain catastrophizing, symptoms of depression and anxiety, limited jaw function, more somatic symptoms, and significantly impaired oral health-related quality of life (all P<0.038).Discussion:The results from the present study showed presence of varied somatosensory abnormalities when assessed using psychophysical and electrophysiological investigations and a significantly impaired psychosocial status.

KW - Key Words:

KW - blink reflex

KW - quality of life

KW - quantitative sensory testing

KW - trigeminal neuropathy

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U2 - 10.1097/AJP.0000000000000806

DO - 10.1097/AJP.0000000000000806

M3 - Journal article

C2 - 31977376

SN - 0749-8047

VL - 36

SP - 321

EP - 335

JO - The Clinical Journal of Pain

JF - The Clinical Journal of Pain

IS - 5

ER -

Assessment of Somatosensory and Psychosocial Function of Patients with Trigeminal Nerve Damage

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Keywords

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