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Assessment of modified gold surfaced titanium implants on skeletal fixation

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Standard

Assessment of modified gold surfaced titanium implants on skeletal fixation. / Zainali, Kasra; Danscher, Gorm; Jakobsen, Thomas; Baas, Jorgen; Møller, Per; Bechtold, Joan E; Soballe, Kjeld.

In: Journal of Biomedical Materials Research. Part A, 2012.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Zainali, K, Danscher, G, Jakobsen, T, Baas, J, Møller, P, Bechtold, JE & Soballe, K 2012, 'Assessment of modified gold surfaced titanium implants on skeletal fixation', Journal of Biomedical Materials Research. Part A. https://doi.org/10.1002/jbm.a.34307

APA

Zainali, K., Danscher, G., Jakobsen, T., Baas, J., Møller, P., Bechtold, J. E., & Soballe, K. (2012). Assessment of modified gold surfaced titanium implants on skeletal fixation. Journal of Biomedical Materials Research. Part A. https://doi.org/10.1002/jbm.a.34307

CBE

Zainali K, Danscher G, Jakobsen T, Baas J, Møller P, Bechtold JE, Soballe K. 2012. Assessment of modified gold surfaced titanium implants on skeletal fixation. Journal of Biomedical Materials Research. Part A. https://doi.org/10.1002/jbm.a.34307

MLA

Zainali, Kasra et al. "Assessment of modified gold surfaced titanium implants on skeletal fixation". Journal of Biomedical Materials Research. Part A. 2012. https://doi.org/10.1002/jbm.a.34307

Vancouver

Zainali K, Danscher G, Jakobsen T, Baas J, Møller P, Bechtold JE et al. Assessment of modified gold surfaced titanium implants on skeletal fixation. Journal of Biomedical Materials Research. Part A. 2012. https://doi.org/10.1002/jbm.a.34307

Author

Zainali, Kasra ; Danscher, Gorm ; Jakobsen, Thomas ; Baas, Jorgen ; Møller, Per ; Bechtold, Joan E ; Soballe, Kjeld. / Assessment of modified gold surfaced titanium implants on skeletal fixation. In: Journal of Biomedical Materials Research. Part A. 2012.

Bibtex

@article{f16004dc23d7439d99d1ea2255f4c0c9,
title = "Assessment of modified gold surfaced titanium implants on skeletal fixation",
abstract = "Noncemented implants are the primary choice for younger patients undergoing total hip replacements. However, the major concern in this group of patients regarding revision is the concern from wear particles, periimplant inflammation, and subsequently aseptic implant loosening. Macrophages have been shown to liberate gold ions through the process termed dissolucytosis. Furthermore, gold ions are known to act in an anti-inflammatory manner by inhibiting cellular NF-κB-DNA binding. The present study investigated whether partial coating of titanium implants could augment early osseointegration and increase mechanical fixation. Cylindrical porous coated Ti-6Al-4V implants partially coated with metallic gold were inserted in the proximal region of the humerus in ten canines and control implants without gold were inserted in contralateral humerus. Observation time was 4 weeks. Biomechanical push out tests and stereological histomorphometrical analyses showed no statistically significant differences in the two groups. The unchanged parameters are considered an improvement of the coating properties, as a previous complete gold-coated implant showed inferior mechanical fixation and reduced osseointegration compared to control titanium implants in a similar model. Since sufficient early mechanical fixation is achieved with this new coating, it is reasonable to investigate the implant further in long-term studies. {\textcopyright} 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A:, 2012.",
author = "Kasra Zainali and Gorm Danscher and Thomas Jakobsen and Jorgen Baas and Per M{\o}ller and Bechtold, {Joan E} and Kjeld Soballe",
note = "Copyright {\textcopyright} 2012 Wiley Periodicals, Inc.",
year = "2012",
doi = "10.1002/jbm.a.34307",
language = "English",
journal = "Journal of Biomedical Materials Research. Part A",
issn = "1549-3296",
publisher = "JohnWiley & Sons, Inc.",

}

RIS

TY - JOUR

T1 - Assessment of modified gold surfaced titanium implants on skeletal fixation

AU - Zainali, Kasra

AU - Danscher, Gorm

AU - Jakobsen, Thomas

AU - Baas, Jorgen

AU - Møller, Per

AU - Bechtold, Joan E

AU - Soballe, Kjeld

N1 - Copyright © 2012 Wiley Periodicals, Inc.

PY - 2012

Y1 - 2012

N2 - Noncemented implants are the primary choice for younger patients undergoing total hip replacements. However, the major concern in this group of patients regarding revision is the concern from wear particles, periimplant inflammation, and subsequently aseptic implant loosening. Macrophages have been shown to liberate gold ions through the process termed dissolucytosis. Furthermore, gold ions are known to act in an anti-inflammatory manner by inhibiting cellular NF-κB-DNA binding. The present study investigated whether partial coating of titanium implants could augment early osseointegration and increase mechanical fixation. Cylindrical porous coated Ti-6Al-4V implants partially coated with metallic gold were inserted in the proximal region of the humerus in ten canines and control implants without gold were inserted in contralateral humerus. Observation time was 4 weeks. Biomechanical push out tests and stereological histomorphometrical analyses showed no statistically significant differences in the two groups. The unchanged parameters are considered an improvement of the coating properties, as a previous complete gold-coated implant showed inferior mechanical fixation and reduced osseointegration compared to control titanium implants in a similar model. Since sufficient early mechanical fixation is achieved with this new coating, it is reasonable to investigate the implant further in long-term studies. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A:, 2012.

AB - Noncemented implants are the primary choice for younger patients undergoing total hip replacements. However, the major concern in this group of patients regarding revision is the concern from wear particles, periimplant inflammation, and subsequently aseptic implant loosening. Macrophages have been shown to liberate gold ions through the process termed dissolucytosis. Furthermore, gold ions are known to act in an anti-inflammatory manner by inhibiting cellular NF-κB-DNA binding. The present study investigated whether partial coating of titanium implants could augment early osseointegration and increase mechanical fixation. Cylindrical porous coated Ti-6Al-4V implants partially coated with metallic gold were inserted in the proximal region of the humerus in ten canines and control implants without gold were inserted in contralateral humerus. Observation time was 4 weeks. Biomechanical push out tests and stereological histomorphometrical analyses showed no statistically significant differences in the two groups. The unchanged parameters are considered an improvement of the coating properties, as a previous complete gold-coated implant showed inferior mechanical fixation and reduced osseointegration compared to control titanium implants in a similar model. Since sufficient early mechanical fixation is achieved with this new coating, it is reasonable to investigate the implant further in long-term studies. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A:, 2012.

U2 - 10.1002/jbm.a.34307

DO - 10.1002/jbm.a.34307

M3 - Journal article

C2 - 22847873

JO - Journal of Biomedical Materials Research. Part A

JF - Journal of Biomedical Materials Research. Part A

SN - 1549-3296

ER -