Assessment of Gastrointestinal Autonomic Dysfunction: Present and Future Perspectives

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Assessment of Gastrointestinal Autonomic Dysfunction : Present and Future Perspectives. / Kornum, Ditte S; Terkelsen, Astrid J; Bertoli, Davide; Klinge, Mette W; Høyer, Katrine L; Kufaishi, Huda H A; Borghammer, Per; Drewes, Asbjørn M; Brock, Christina; Krogh, Klaus.

In: Journal of Clinical Medicine, Vol. 10, No. 7, 1392, 04.2021.

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@article{8d238425e57a42c0a4d005cc0004494a,
title = "Assessment of Gastrointestinal Autonomic Dysfunction: Present and Future Perspectives",
abstract = "The autonomic nervous system delicately regulates the function of several target organs, including the gastrointestinal tract. Thus, nerve lesions or other nerve pathologies may cause autonomic dysfunction (AD). Some of the most common causes of AD are diabetes mellitus and α-synucleinopathies such as Parkinson's disease. Widespread dysmotility throughout the gastrointestinal tract is a common finding in AD, but no commercially available method exists for direct verification of enteric dysfunction. Thus, assessing segmental enteric physiological function is recommended to aid diagnostics and guide treatment. Several established assessment methods exist, but disadvantages such as lack of standardization, exposure to radiation, advanced data interpretation, or high cost, limit their utility. Emerging methods, including high-resolution colonic manometry, 3D-transit, advanced imaging methods, analysis of gut biopsies, and microbiota, may all assist in the evaluation of gastroenteropathy related to AD. This review provides an overview of established and emerging assessment methods of physiological function within the gut and assessment methods of autonomic neuropathy outside the gut, especially in regards to clinical performance, strengths, and limitations for each method.",
author = "Kornum, {Ditte S} and Terkelsen, {Astrid J} and Davide Bertoli and Klinge, {Mette W} and H{\o}yer, {Katrine L} and Kufaishi, {Huda H A} and Per Borghammer and Drewes, {Asbj{\o}rn M} and Christina Brock and Klaus Krogh",
year = "2021",
month = apr,
doi = "10.3390/jcm10071392",
language = "English",
volume = "10",
journal = "Journal of Clinical Medicine",
issn = "2077-0383",
publisher = "MDPI AG",
number = "7",

}

RIS

TY - JOUR

T1 - Assessment of Gastrointestinal Autonomic Dysfunction

T2 - Present and Future Perspectives

AU - Kornum, Ditte S

AU - Terkelsen, Astrid J

AU - Bertoli, Davide

AU - Klinge, Mette W

AU - Høyer, Katrine L

AU - Kufaishi, Huda H A

AU - Borghammer, Per

AU - Drewes, Asbjørn M

AU - Brock, Christina

AU - Krogh, Klaus

PY - 2021/4

Y1 - 2021/4

N2 - The autonomic nervous system delicately regulates the function of several target organs, including the gastrointestinal tract. Thus, nerve lesions or other nerve pathologies may cause autonomic dysfunction (AD). Some of the most common causes of AD are diabetes mellitus and α-synucleinopathies such as Parkinson's disease. Widespread dysmotility throughout the gastrointestinal tract is a common finding in AD, but no commercially available method exists for direct verification of enteric dysfunction. Thus, assessing segmental enteric physiological function is recommended to aid diagnostics and guide treatment. Several established assessment methods exist, but disadvantages such as lack of standardization, exposure to radiation, advanced data interpretation, or high cost, limit their utility. Emerging methods, including high-resolution colonic manometry, 3D-transit, advanced imaging methods, analysis of gut biopsies, and microbiota, may all assist in the evaluation of gastroenteropathy related to AD. This review provides an overview of established and emerging assessment methods of physiological function within the gut and assessment methods of autonomic neuropathy outside the gut, especially in regards to clinical performance, strengths, and limitations for each method.

AB - The autonomic nervous system delicately regulates the function of several target organs, including the gastrointestinal tract. Thus, nerve lesions or other nerve pathologies may cause autonomic dysfunction (AD). Some of the most common causes of AD are diabetes mellitus and α-synucleinopathies such as Parkinson's disease. Widespread dysmotility throughout the gastrointestinal tract is a common finding in AD, but no commercially available method exists for direct verification of enteric dysfunction. Thus, assessing segmental enteric physiological function is recommended to aid diagnostics and guide treatment. Several established assessment methods exist, but disadvantages such as lack of standardization, exposure to radiation, advanced data interpretation, or high cost, limit their utility. Emerging methods, including high-resolution colonic manometry, 3D-transit, advanced imaging methods, analysis of gut biopsies, and microbiota, may all assist in the evaluation of gastroenteropathy related to AD. This review provides an overview of established and emerging assessment methods of physiological function within the gut and assessment methods of autonomic neuropathy outside the gut, especially in regards to clinical performance, strengths, and limitations for each method.

U2 - 10.3390/jcm10071392

DO - 10.3390/jcm10071392

M3 - Review

C2 - 33807256

VL - 10

JO - Journal of Clinical Medicine

JF - Journal of Clinical Medicine

SN - 2077-0383

IS - 7

M1 - 1392

ER -