ARS2/SRRT: At the nexus of RNA polymerase II transcription, transcript maturation and quality control

Søren Lykke-Andersen; Jérôme O. Rouvière; Torben Heick Jensen

doi:10.1042/BST20201008

ARS2/SRRT: At the nexus of RNA polymerase II transcription, transcript maturation and quality control

Søren Lykke-Andersen, Jérôme O. Rouvière, Torben Heick Jensen^*

^*Corresponding author for this work

Department of Molecular Biology and Genetics - RNA Biology and Innovation

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review

Abstract

ARS2/SRRT is an essential eukaryotic protein that has emerged as a critical factor in the sorting of functional from non-functional RNA polymerase II (Pol II) transcripts. Through its interaction with the Cap Binding Complex (CBC), it associates with the cap of newly made RNAs and acts as a hub for competitive exchanges of protein factors that ultimately determine the fate of the associated RNA. The central position of the protein within the nuclear gene expression machinery likely explains why its depletion causes a broad range of phenotypes, yet an exact function of the protein remains elusive. Here, we consider the literature on ARS2/SRRT with the attempt to garner the threads into a unifying working model for ARS2/SRRT function at the nexus of Pol II transcription, transcript maturation and quality control.

Original language	English
Journal	Biochemical Society Transactions
Volume	49
Issue	3
Pages (from-to)	1325-1336
Number of pages	12
ISSN	0300-5127
DOIs	https://doi.org/10.1042/BST20201008
Publication status	Published - Jun 2021

Access to Document

10.1042/BST20201008

Cite this

@article{95a423929cf549c8abc8e29611fa5b63,

title = "ARS2/SRRT: At the nexus of RNA polymerase II transcription, transcript maturation and quality control",

abstract = "ARS2/SRRT is an essential eukaryotic protein that has emerged as a critical factor in the sorting of functional from non-functional RNA polymerase II (Pol II) transcripts. Through its interaction with the Cap Binding Complex (CBC), it associates with the cap of newly made RNAs and acts as a hub for competitive exchanges of protein factors that ultimately determine the fate of the associated RNA. The central position of the protein within the nuclear gene expression machinery likely explains why its depletion causes a broad range of phenotypes, yet an exact function of the protein remains elusive. Here, we consider the literature on ARS2/SRRT with the attempt to garner the threads into a unifying working model for ARS2/SRRT function at the nexus of Pol II transcription, transcript maturation and quality control.",

author = "S{\o}ren Lykke-Andersen and Rouvi{\`e}re, {J{\'e}r{\^o}me O.} and Jensen, {Torben Heick}",

note = "Publisher Copyright: {\textcopyright} 2021 The Author(s).",

year = "2021",

month = jun,

doi = "10.1042/BST20201008",

language = "English",

volume = "49",

pages = "1325--1336",

journal = "Biochemical Society Transactions",

issn = "0300-5127",

publisher = "Portland Press Ltd.",

number = "3",

}

ARS2/SRRT: At the nexus of RNA polymerase II transcription, transcript maturation and quality control. / Lykke-Andersen, Søren ; Rouvière, Jérôme O.; Jensen, Torben Heick.
In: Biochemical Society Transactions, Vol. 49, No. 3, 06.2021, p. 1325-1336.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review

TY - JOUR

T1 - ARS2/SRRT

T2 - At the nexus of RNA polymerase II transcription, transcript maturation and quality control

AU - Lykke-Andersen, Søren

AU - Rouvière, Jérôme O.

AU - Jensen, Torben Heick

PY - 2021/6

Y1 - 2021/6

N2 - ARS2/SRRT is an essential eukaryotic protein that has emerged as a critical factor in the sorting of functional from non-functional RNA polymerase II (Pol II) transcripts. Through its interaction with the Cap Binding Complex (CBC), it associates with the cap of newly made RNAs and acts as a hub for competitive exchanges of protein factors that ultimately determine the fate of the associated RNA. The central position of the protein within the nuclear gene expression machinery likely explains why its depletion causes a broad range of phenotypes, yet an exact function of the protein remains elusive. Here, we consider the literature on ARS2/SRRT with the attempt to garner the threads into a unifying working model for ARS2/SRRT function at the nexus of Pol II transcription, transcript maturation and quality control.

AB - ARS2/SRRT is an essential eukaryotic protein that has emerged as a critical factor in the sorting of functional from non-functional RNA polymerase II (Pol II) transcripts. Through its interaction with the Cap Binding Complex (CBC), it associates with the cap of newly made RNAs and acts as a hub for competitive exchanges of protein factors that ultimately determine the fate of the associated RNA. The central position of the protein within the nuclear gene expression machinery likely explains why its depletion causes a broad range of phenotypes, yet an exact function of the protein remains elusive. Here, we consider the literature on ARS2/SRRT with the attempt to garner the threads into a unifying working model for ARS2/SRRT function at the nexus of Pol II transcription, transcript maturation and quality control.

UR - http://www.scopus.com/inward/record.url?scp=85109033216&partnerID=8YFLogxK

U2 - 10.1042/BST20201008

DO - 10.1042/BST20201008

M3 - Review

C2 - 34060620

AN - SCOPUS:85109033216

SN - 0300-5127

VL - 49

SP - 1325

EP - 1336

JO - Biochemical Society Transactions

JF - Biochemical Society Transactions

IS - 3

ER -

ARS2/SRRT: At the nexus of RNA polymerase II transcription, transcript maturation and quality control

Abstract

Access to Document

Other files and links

Fingerprint

Cite this