Array comparative genomic hybridization of keratoacanthomas and squamous cell carcinomas: different patterns of genetic aberrations suggest two distinct entities

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • Jian Li, Denmark
  • Kai Wang, Denmark
  • Fei Gao
  • ,
  • Thomas D Jensen, Denmark
  • Shengting T Li, Denmark
  • Paula M Deangelis
  • ,
  • Steen Kølvraa, Denmark
  • Charlotte Proby
  • ,
  • Ola Forslund
  • ,
  • Lars Bolund
  • Ole Petter F Clausen
Keratoacanthoma (KA) is a benign keratinocytic neoplasm that spontaneously regresses after 3-6 months and shares features with squamous cell carcinomas (SCCs). Furthermore, there are reports of KAs that have metastasized, invoking the question of whether KA is a variant of SCC (Hodak et al., 1993). To date, no reported criteria are sensitive enough to discriminate reliably between KA and SCC, and consequently there is a clinical need for discriminating markers. Our previous study analyzed 132 KAs and 29 SCCs and revealed significantly different regions of genomic aberrations using chromosomal comparative genomic hybridization (CGH). In the present study, we applied array CGH to investigate 98 KAs and 22 SCCs from the above samples. The result shows that all KAs and SCCs have some degree of genetic aberrations. The distribution of numbers of aberrant clones per sample differed significantly between KAs and SCCs (P
Original languageEnglish
JournalJournal of Investigative Dermatology
Volume132
Issue8
Pages (from-to)2060-6
Number of pages7
ISSN0022-202X
DOIs
Publication statusPublished - 2012

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