Are TMEM genes potential candidate genes for panic disorder?

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearch

  • Noomi O Gregersen
  • ,
  • Henriette Nørmølle Buttenschøn
  • Anne Hedemand
  • Hans Atli Dahl, Klinisk Biokemi, Denmark
  • Ann S Kristensen, Denmark
  • Birita Clementsen
  • ,
  • David P D Woldbye, Denmark
  • Pernille Koefoed, Institut for Neurovidenskab og Farmakologi, Denmark
  • Angelika Erhardt
  • ,
  • Torben A Kruse, Human Genetik, Denmark
  • August Gabriel Wang, Institut for Klinisk Medicin, Denmark
  • Anders D Børglum
  • Ole Mors
We analysed single nucleotide polymorphisms in two transmembrane genes (TMEM98 and TMEM132E) in panic disorder (PD) patients and control individuals from the Faroe Islands, Denmark and Germany. The genes encode single-pass membrane proteins and are located within chromosome 17q11.2-q12, a previously reported candidate region for PD. Three single nucleotide polymorphisms (rs887231, rs887230 and rs4795942) located upstream and within TMEM132E showed a nominal significant association with PD primarily in the Danish cohort. No nominal significant associations were observed between TMEM98 and PD. Our data indicate that TMEM132E might contribute moderately towards the risk of developing PD.
Original languageEnglish
JournalPsychiatric Genetics
Pages (from-to)37-41
Number of pages5
Publication statusPublished - Feb 2014

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