Are microRNAs located in cancer specific regions in the genome?

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  • Bioinformatics Research Centre (BiRC)
  • Department of clinical biochemistry
We report on the location of 283 miRNAs in the human genome in relation to copy number changes in three distinct types of tumours: prostate, bladder and colon. In prostate and colon tumours, we find miRNAs over-represented in regions with copy number gain and under-represented in regions with copy number loss. Surprisingly this pattern appears to be reversed in bladder cancer. We compared our miRNA copy number data to published miRNA expression data; unexpectedly, we did not find a statistically significant relationship between miRNA copy number and expression level. This suggests that miRNA expression is regulated through different mechanisms than mRNA expression.
Original languageEnglish
JournalBritish Journal of Cancer
Pages (from-to)1415-8
Number of pages4
Publication statusPublished - 2006

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