Are microRNAs located in cancer specific regions in the genome?

TY - JOUR

T1 -  Are microRNAs located in cancer specific regions in the genome?

AU - Lamy, Philippe

AU - Andersen, Claus Lindbjerg

AU - Andersen, Lars Dyrskjøt

AU - Tørring, Niels

AU - Ørntoft, Torben Falck

AU - Wiuf, Carsten

PY - 2006

Y1 - 2006

N2 - We report on the location of 283 miRNAs in the human genome in relation to copy number changes in three distinct types of tumours: prostate, bladder and colon. In prostate and colon tumours, we find miRNAs over-represented in regions with copy number gain and under-represented in regions with copy number loss. Surprisingly this pattern appears to be reversed in bladder cancer. We compared our miRNA copy number data to published miRNA expression data; unexpectedly, we did not find a statistically significant relationship between miRNA copy number and expression level. This suggests that miRNA expression is regulated through different mechanisms than mRNA expression.

AB - We report on the location of 283 miRNAs in the human genome in relation to copy number changes in three distinct types of tumours: prostate, bladder and colon. In prostate and colon tumours, we find miRNAs over-represented in regions with copy number gain and under-represented in regions with copy number loss. Surprisingly this pattern appears to be reversed in bladder cancer. We compared our miRNA copy number data to published miRNA expression data; unexpectedly, we did not find a statistically significant relationship between miRNA copy number and expression level. This suggests that miRNA expression is regulated through different mechanisms than mRNA expression.

U2 - 10.1038/sj.bjc.6603381

DO - 10.1038/sj.bjc.6603381

M3 - Journal article

C2 - 17003783

SN - 0007-0920

VL - 95

SP - 1415

EP - 1418

JO - British Journal of Cancer

JF - British Journal of Cancer

IS - 10

ER -