Are informants required to obtain valid ratings on the Positive and Negative Syndrome Scale (PANSS)?

Cecilie Marie Nielsen, Pernille Kølbæk*, David Dines, Mark Opler, Christoph U Correll, Søren Dinesen Østergaard

*Corresponding author for this work

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Abstract

Ratings on the Positive and Negative Syndrome Scale (PANSS) are ideally based on both a patient interview and an informant questionnaire. In research and clinical settings, however, the informant questionnaire is often omitted. This study investigated the consequences of omitting informant information by comparing PANSS ratings of patients with schizophrenia (n = 49 patients, 77 ratings) conducted with and without informant information, respectively. Additionally, changes in symptom severity over time based on ratings with and without informant information were also compared for the full PANSS and the six-item version of the PANSS (PANSS-6). PANSS ratings including informant information were higher than those without, both at the total score and individual item level. Additionally, the full PANSS appeared less "responsive" to baseline-to-endpoint changes for ratings without informant information compared to ratings including informant information, while no differences were found for the PANSS-6.

Original languageEnglish
Article number54
JournalSchizophrenia
Volume9
Issue1
ISSN2754-6993
DOIs
Publication statusPublished - Aug 2023

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