Appraisal of Proactive Topical Therapy in Atopic Dermatitis: Pros and Cons

Anne Sofie Frølunde; Jacob Pontoppidan Thyssen; Mette Deleuran; Christian Vestergaard

doi:10.1007/s40257-021-00629-0

Appraisal of Proactive Topical Therapy in Atopic Dermatitis: Pros and Cons

Anne Sofie Frølunde, Jacob Pontoppidan Thyssen, Mette Deleuran, Christian Vestergaard^*

^*Corresponding author for this work

Department of Clinical Medicine - The Department of Dermatology and Venereology

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review

14 Citations (Scopus)

Abstract

Atopic dermatitis is a common inflammatory skin disease that can affect both children and adults. It is a chronic disease with recurrent, highly pruritic eczematous lesions. Topical treatment with anti-inflammatory agents is the mainstay of treatment for atopic dermatitis, either in a reactive or proactive approach according to severity of the disease and always in combination with daily application of an emollient cream. Several studies have shown that proactive therapy with either topical corticosteroids or topical calcineurin inhibitors is significantly superior at reducing the number of flares and increasing the interval between flares compared with reactive therapy in patients with moderate and severe disease. The risk of side effects is considered low, and there seem to be no extra economic costs related to this treatment approach. Proactive therapy is an advisable treatment option for patients with moderate and severe atopic dermatitis to gain prolonged disease control; however, long-term safety data and data on when to stop do not yet exist.

Original language	English
Journal	American Journal of Clinical Dermatology
Volume	22
Issue	6
Pages (from-to)	775-783
Number of pages	9
ISSN	1175-0561
DOIs	https://doi.org/10.1007/s40257-021-00629-0
Publication status	Published - Nov 2021

Keywords

CALCINEURIN INHIBITORS
CRISABOROLE OINTMENT
DOUBLE-BLIND
FLUTICASONE PROPIONATE
LONG-TERM TREATMENT
MAINTENANCE TREATMENT
PIMECROLIMUS CREAM 1-PERCENT
POSITION PAPER
TACROLIMUS OINTMENT
TASK-FORCE

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10.1007/s40257-021-00629-0

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title = "Appraisal of Proactive Topical Therapy in Atopic Dermatitis: Pros and Cons",

abstract = "Atopic dermatitis is a common inflammatory skin disease that can affect both children and adults. It is a chronic disease with recurrent, highly pruritic eczematous lesions. Topical treatment with anti-inflammatory agents is the mainstay of treatment for atopic dermatitis, either in a reactive or proactive approach according to severity of the disease and always in combination with daily application of an emollient cream. Several studies have shown that proactive therapy with either topical corticosteroids or topical calcineurin inhibitors is significantly superior at reducing the number of flares and increasing the interval between flares compared with reactive therapy in patients with moderate and severe disease. The risk of side effects is considered low, and there seem to be no extra economic costs related to this treatment approach. Proactive therapy is an advisable treatment option for patients with moderate and severe atopic dermatitis to gain prolonged disease control; however, long-term safety data and data on when to stop do not yet exist.",

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Appraisal of Proactive Topical Therapy in Atopic Dermatitis: Pros and Cons. / Frølunde, Anne Sofie; Thyssen, Jacob Pontoppidan; Deleuran, Mette et al.
In: American Journal of Clinical Dermatology, Vol. 22, No. 6, 11.2021, p. 775-783.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review

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AU - Vestergaard, Christian

PY - 2021/11

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AB - Atopic dermatitis is a common inflammatory skin disease that can affect both children and adults. It is a chronic disease with recurrent, highly pruritic eczematous lesions. Topical treatment with anti-inflammatory agents is the mainstay of treatment for atopic dermatitis, either in a reactive or proactive approach according to severity of the disease and always in combination with daily application of an emollient cream. Several studies have shown that proactive therapy with either topical corticosteroids or topical calcineurin inhibitors is significantly superior at reducing the number of flares and increasing the interval between flares compared with reactive therapy in patients with moderate and severe disease. The risk of side effects is considered low, and there seem to be no extra economic costs related to this treatment approach. Proactive therapy is an advisable treatment option for patients with moderate and severe atopic dermatitis to gain prolonged disease control; however, long-term safety data and data on when to stop do not yet exist.

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KW - CRISABOROLE OINTMENT

KW - DOUBLE-BLIND

KW - FLUTICASONE PROPIONATE

KW - LONG-TERM TREATMENT

KW - MAINTENANCE TREATMENT

KW - PIMECROLIMUS CREAM 1-PERCENT

KW - POSITION PAPER

KW - TACROLIMUS OINTMENT

KW - TASK-FORCE

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JO - American Journal of Clinical Dermatology

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Appraisal of Proactive Topical Therapy in Atopic Dermatitis: Pros and Cons

Abstract

Keywords

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