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Applying Spike-density component analysis for high-accuracy auditory event-related potentials in children

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Objective
Overlapping neurophysiological signals are the main obstacle preventing from using cortical auditory event-related potentials (AEPs) in clinical settings. Children AEPs are particularly affected by this problem, as their cerebral cortex is still maturing. To overcome this problem, we applied a new version of Spike-density Component Analysis (SCA), an analysis method recently developed, to isolate with high accuracy the neural components of auditory responses of 8-year-old children.

Methods
Electroencephalography was used with 33 children to record AEPs to auditory stimuli varying in spectrotemporal features. Three different analysis approaches were adopted: the standard AEP analysis procedure, SCA with template-match (SCA-TM), and SCA with half-split average consistency (SCA-HSAC).

Results
SCA-HSAC most successfully allowed the extraction of AEPs for each child, revealing that the most consistent components were P1 and N2. An immature N1 component was also detected.

Conclusion
Superior accuracy in isolating neural components at the individual level was demonstrated for SCA-HSAC over other SCA approaches even for children AEPs.

Significance
Reliable methods of extraction of neurophysiological signals at the individual level are crucial for the application of cortical AEPs for routine diagnostic exams in clinical settings both in children and adults.
Original languageEnglish
JournalClinical Neurophysiology
Volume132
Issue8
Pages (from-to)1887-1896
Number of pages10
ISSN1388-2457
DOIs
Publication statusPublished - Aug 2021

    Research areas

  • Auditory event-related potentials (AEP), Spike-density component analysis (SCA), ERP (event-related potential), Cortical maturation, Children

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