Anxiety and depression in Klinefelter syndrome: The impact of personality and social engagement

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  • Anne Skakkebæk
  • Philip J Moore, Department of Psychology, The George Washington University, Washington DC, United States of America.
  • ,
  • Anders Degn Pedersen
  • Anders Bojesen, Department of Clinical Genetics, Sygehus Lillebaelt, Vejle, Denmark.
  • ,
  • Maria Krarup Kristensen, Department of Mental Health, Odense University Clinic, Odense, Denmark.
  • ,
  • Jens Fedder, Centre of Andrology and Fertility Clinic, Department D, Odense University Hospital, Odense, Denmark.
  • ,
  • Jens Michael Hertz, Department of Clinical Genetics, Odense University Hospital, Odense, Denmark.
  • ,
  • John R Østergaard
  • Mikkel Wallentin
  • Claus Højbjerg Gravholt

Klinefelter syndrome (KS) (47, XXY) is the most common sex chromosome disorder, with a prevalence of 1 in every 660 newborn males. Despite the profound adverse effects of anxiety and depression, and their greater prevalence in KS populations, no research has been conducted to date to identify the determinants of anxiety and depression among patients with KS. We examined the relationships between personality traits, social engagement, and anxiety and depression symptoms among KS patients (n = 69) and a group of male controls (n = 69) matched for age and years of education. KS patients experienced more anxiety and depression symptoms than control participants. Neuroticism was the strongest and most consistent mediator between KS and both anxiety and depression symptoms. This research suggests that neuroticism may play a central role in attention switching, anxiety and depression among patients with Klinefelter syndrome. The central role of neuroticism suggests that it may be used to help identify and treat KS patients at particularly high-risk for attention-switching deficits, anxiety and depression.

Original languageEnglish
Article numbere0206932
Publication statusPublished - 2018

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