Anti-tumor necrosis factor treatment increases both the Th17 and Th22 T helper subsets in spondyloarthritis

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DOI

The aim was to examine anti-tumor necrosis factor α (anti-TNFα) therapy influence changes on Th17 and Th22 cells in patients with spondyloarthritis (SpA), and its correlation with changes in clinical and magnetic resonance imaging (MRI) activity and chronicity scores. The Th17 and Th22 cells were assessed at baseline, after 12 and 52 weeks of anti-TNFα therapy by flow cytometry (ClinicalTrials.gov NCT4682724). The percentages of both Th17 and Th22 cells were increased by 70% at baseline compared with healthy controls (both p < 0.01). During treatment, these two subsets increased further to be 170% (Th17) and 123% (Th22) above levels in healthy controls (both p < 0.01). The same subsets decrease their expression of IL-23R significantly during the observation period (p < 0.05). High levels of Th17 and Th22 cells at baseline were associated with the degree of chronic changes in the sacroiliac joints on MRI and a good clinical response to anti-TNFα treatment after one year. Plasma levels were not associated with clinical changes. Th17 cells, and Th22 subsets, increased during one year of anti-TNF-α therapy in SpA, regardless of their clinical improvement. This supports that both the Th17 and Th22 subsets could be involved in the progression in SpA.

Original languageEnglish
Book seriesAPMIS
Volume127
Issue12
Pages (from-to)789-796
Number of pages8
ISSN0903-4641
DOIs
Publication statusPublished - Dec 2019

Bibliographical note

© 2019 APMIS. Published by John Wiley & Sons Ltd.

    Research areas

  • anti-TNF alpha therapy, immunology, interleukin, Spondyloarthritis, Th17 cells, Th22 cells, therapy, CELLS, IL-17 RECEPTOR, EFFICACY, INTERLEUKIN 22, ANKYLOSING-SPONDYLITIS, ARTHRITIS, SECUKINUMAB, T(H)17, DOUBLE-BLIND, ANTI-INTERLEUKIN-17A MONOCLONAL-ANTIBODY, Interleukins/metabolism, Spondylarthritis/diagnostic imaging, Humans, Middle Aged, Interleukin-17/metabolism, Male, Receptors, Interleukin/metabolism, T-Lymphocytes, Helper-Inducer/drug effects, Tumor Necrosis Factor-alpha/antagonists & inhibitors, Flow Cytometry, Adult, Female, Th17 Cells/drug effects, Anti-Inflammatory Agents/pharmacology, Treatment Outcome, Magnetic Resonance Imaging

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