Antiresorptive Therapy for Osteoporosis in Older Subjects

Anne Sophie Sølling; Natasha Amran Laursen; Torben Harsløf; Bente Lomholt Langdahl

doi:10.1159/000544781

Antiresorptive Therapy for Osteoporosis in Older Subjects

Anne Sophie Sølling^*, Natasha Amran Laursen, Torben Harsløf, Bente Lomholt Langdahl

^*Corresponding author for this work

Department of Clinical Medicine - Department of Endocrinology and Internal Medicine

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Abstract

Background: Osteoporosis increases the risk of fractures and mortality, particularly in the elderly population. However, prescribing antiresorptive medication to elderly patients with osteoporosis is complex. The benefitrisk ratio should be considered for all patients but can be particularly challenging in older individuals due to factors like comorbidities, polypharmacy, fall risk, and potential rare side effects of long-Term treatment. Summary: We reviewed the efficacy and safety of antiresorptive treatments, including calcium and vitamin D supplementation, in elderly patients by evaluating published trials, reviews, and meta-Analyses. Our findings confirm that antiresorptive treatment for osteoporosis is both effective and safe in the elderly population. Key Messages: One key challenge is ensuring compliance, which can be difficult for some elderly patients. In such cases, intravenously or subcutaneously administered antiresorptive treatment should be considered to improve adherence and overall treatment compliance.

Original language	English
Journal	Gerontology
Volume	71
Issue	4
Pages (from-to)	297-307
Number of pages	11
ISSN	0304-324X
DOIs	https://doi.org/10.1159/000544781
Publication status	Published - 1 Apr 2025

Keywords

Antiresorptives
Bone mineral density
Elderly
Fracture
Osteoporosis
Safety

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10.1159/000544781

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title = "Antiresorptive Therapy for Osteoporosis in Older Subjects",

abstract = "Background: Osteoporosis increases the risk of fractures and mortality, particularly in the elderly population. However, prescribing antiresorptive medication to elderly patients with osteoporosis is complex. The benefitrisk ratio should be considered for all patients but can be particularly challenging in older individuals due to factors like comorbidities, polypharmacy, fall risk, and potential rare side effects of long-Term treatment. Summary: We reviewed the efficacy and safety of antiresorptive treatments, including calcium and vitamin D supplementation, in elderly patients by evaluating published trials, reviews, and meta-Analyses. Our findings confirm that antiresorptive treatment for osteoporosis is both effective and safe in the elderly population. Key Messages: One key challenge is ensuring compliance, which can be difficult for some elderly patients. In such cases, intravenously or subcutaneously administered antiresorptive treatment should be considered to improve adherence and overall treatment compliance.",

keywords = "Antiresorptives, Bone mineral density, Elderly, Fracture, Osteoporosis, Safety",

author = "S{\o}lling, {Anne Sophie} and Laursen, {Natasha Amran} and Torben Harsl{\o}f and Langdahl, {Bente Lomholt}",

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doi = "10.1159/000544781",

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AU - Sølling, Anne Sophie

AU - Laursen, Natasha Amran

AU - Harsløf, Torben

AU - Langdahl, Bente Lomholt

PY - 2025/4/1

Y1 - 2025/4/1

N2 - Background: Osteoporosis increases the risk of fractures and mortality, particularly in the elderly population. However, prescribing antiresorptive medication to elderly patients with osteoporosis is complex. The benefitrisk ratio should be considered for all patients but can be particularly challenging in older individuals due to factors like comorbidities, polypharmacy, fall risk, and potential rare side effects of long-Term treatment. Summary: We reviewed the efficacy and safety of antiresorptive treatments, including calcium and vitamin D supplementation, in elderly patients by evaluating published trials, reviews, and meta-Analyses. Our findings confirm that antiresorptive treatment for osteoporosis is both effective and safe in the elderly population. Key Messages: One key challenge is ensuring compliance, which can be difficult for some elderly patients. In such cases, intravenously or subcutaneously administered antiresorptive treatment should be considered to improve adherence and overall treatment compliance.

AB - Background: Osteoporosis increases the risk of fractures and mortality, particularly in the elderly population. However, prescribing antiresorptive medication to elderly patients with osteoporosis is complex. The benefitrisk ratio should be considered for all patients but can be particularly challenging in older individuals due to factors like comorbidities, polypharmacy, fall risk, and potential rare side effects of long-Term treatment. Summary: We reviewed the efficacy and safety of antiresorptive treatments, including calcium and vitamin D supplementation, in elderly patients by evaluating published trials, reviews, and meta-Analyses. Our findings confirm that antiresorptive treatment for osteoporosis is both effective and safe in the elderly population. Key Messages: One key challenge is ensuring compliance, which can be difficult for some elderly patients. In such cases, intravenously or subcutaneously administered antiresorptive treatment should be considered to improve adherence and overall treatment compliance.

KW - Antiresorptives

KW - Bone mineral density

KW - Elderly

KW - Fracture

KW - Osteoporosis

KW - Safety

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Antiresorptive Therapy for Osteoporosis in Older Subjects

Abstract

Keywords

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