Antioxidant Microgels Support Peroxide-Challenged Hepatic Cells

Isabella Nymann Westensee; Karen Louise Thomsen; Rajeshwar Prosad Mookerjee; Brigitte Maria Stadler

doi:10.1002/adbi.202300547

Antioxidant Microgels Support Peroxide-Challenged Hepatic Cells

Isabella Nymann Westensee, Karen Louise Thomsen, Rajeshwar Prosad Mookerjee, Brigitte Maria Stadler^*

^*Corresponding author for this work

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

1 Citation (Scopus)

Abstract

Access to therapeutic strategies that counter cellular stress induced by reactive oxygen species (ROS) is an important, long-standing challenge. Here, the assembly of antioxidant artificial cells is based on alginate hydrogels equipped with non-native catalysts, namely platinum nanoparticles and an EUK compound. These artificial cells are able to preserve the viability and lower the intracellular ROS levels of challenged hepatic cells by removing peroxides from the extracellular environment. Conceptually, this strategy illustrates the potential use of artificial cells with a synthetic catalyst toward long-term support of hepatic cells and potentially other mammalian cells.

Original language	English
Article number	e2300547
Journal	Advanced Biology
Volume	8
Issue	4
Number of pages	10
ISSN	2701-0198
DOIs	https://doi.org/10.1002/adbi.202300547
Publication status	Published - Apr 2024

Keywords

Animals
Antioxidants/pharmacology
Hepatocytes
Mammals
Metal Nanoparticles
Microgels
Peroxides
Platinum
Reactive Oxygen Species
antioxidants
hydrogels
EUK compounds
hepatocytes
reactive oxygen species

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10.1002/adbi.202300547Licence: CC BY

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title = "Antioxidant Microgels Support Peroxide-Challenged Hepatic Cells",

abstract = "Access to therapeutic strategies that counter cellular stress induced by reactive oxygen species (ROS) is an important, long-standing challenge. Here, the assembly of antioxidant artificial cells is based on alginate hydrogels equipped with non-native catalysts, namely platinum nanoparticles and an EUK compound. These artificial cells are able to preserve the viability and lower the intracellular ROS levels of challenged hepatic cells by removing peroxides from the extracellular environment. Conceptually, this strategy illustrates the potential use of artificial cells with a synthetic catalyst toward long-term support of hepatic cells and potentially other mammalian cells.",

keywords = "Animals, Antioxidants/pharmacology, Hepatocytes, Mammals, Metal Nanoparticles, Microgels, Peroxides, Platinum, Reactive Oxygen Species, antioxidants, hydrogels, EUK compounds, hepatocytes, reactive oxygen species",

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T1 - Antioxidant Microgels Support Peroxide-Challenged Hepatic Cells

AU - Westensee, Isabella Nymann

AU - Thomsen, Karen Louise

AU - Mookerjee, Rajeshwar Prosad

AU - Stadler, Brigitte Maria

PY - 2024/4

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N2 - Access to therapeutic strategies that counter cellular stress induced by reactive oxygen species (ROS) is an important, long-standing challenge. Here, the assembly of antioxidant artificial cells is based on alginate hydrogels equipped with non-native catalysts, namely platinum nanoparticles and an EUK compound. These artificial cells are able to preserve the viability and lower the intracellular ROS levels of challenged hepatic cells by removing peroxides from the extracellular environment. Conceptually, this strategy illustrates the potential use of artificial cells with a synthetic catalyst toward long-term support of hepatic cells and potentially other mammalian cells.

AB - Access to therapeutic strategies that counter cellular stress induced by reactive oxygen species (ROS) is an important, long-standing challenge. Here, the assembly of antioxidant artificial cells is based on alginate hydrogels equipped with non-native catalysts, namely platinum nanoparticles and an EUK compound. These artificial cells are able to preserve the viability and lower the intracellular ROS levels of challenged hepatic cells by removing peroxides from the extracellular environment. Conceptually, this strategy illustrates the potential use of artificial cells with a synthetic catalyst toward long-term support of hepatic cells and potentially other mammalian cells.

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KW - Mammals

KW - Metal Nanoparticles

KW - Microgels

KW - Peroxides

KW - Platinum

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KW - antioxidants

KW - hydrogels

KW - EUK compounds

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VL - 8

JO - Advanced Biology

JF - Advanced Biology

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Antioxidant Microgels Support Peroxide-Challenged Hepatic Cells

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Keywords

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