Antioxidant Microgels Support Peroxide-Challenged Hepatic Cells

Isabella Nymann Westensee, Karen Louise Thomsen, Rajeshwar Prosad Mookerjee, Brigitte Maria Stadler*

*Corresponding author for this work

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Abstract

Access to therapeutic strategies that counter cellular stress induced by reactive oxygen species (ROS) is an important, long-standing challenge. Here, the assembly of antioxidant artificial cells is based on alginate hydrogels equipped with non-native catalysts, namely platinum nanoparticles and an EUK compound. These artificial cells are able to preserve the viability and lower the intracellular ROS levels of challenged hepatic cells by removing peroxides from the extracellular environment. Conceptually, this strategy illustrates the potential use of artificial cells with a synthetic catalyst toward long-term support of hepatic cells and potentially other mammalian cells.

Original languageEnglish
Article numbere2300547
JournalAdvanced Biology
Volume8
Issue4
Number of pages10
ISSN2701-0198
DOIs
Publication statusPublished - Apr 2024

Keywords

  • Animals
  • Antioxidants/pharmacology
  • Hepatocytes
  • Mammals
  • Metal Nanoparticles
  • Microgels
  • Peroxides
  • Platinum
  • Reactive Oxygen Species

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