Anthropometric and biochemical correlates of PAPP-A2, free IGF-I, and IGFBP-3 in childhood

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Anthropometric and biochemical correlates of PAPP-A2, free IGF-I, and IGFBP-3 in childhood. / Fujimoto, Masanobu; Khoury, Jane C.; Khoury, Philip R.; Kalra, Bhanu; Kumar, Ajay; Sluss, Patrick; Oxvig, Claus; Hwa, Vivian; Dauber, Andrew.

In: European Journal of Endocrinology, Vol. 182, No. 3, 2020, p. 363-374.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Fujimoto, M, Khoury, JC, Khoury, PR, Kalra, B, Kumar, A, Sluss, P, Oxvig, C, Hwa, V & Dauber, A 2020, 'Anthropometric and biochemical correlates of PAPP-A2, free IGF-I, and IGFBP-3 in childhood', European Journal of Endocrinology, vol. 182, no. 3, pp. 363-374. https://doi.org/10.1530/EJE-19-0859

APA

Fujimoto, M., Khoury, J. C., Khoury, P. R., Kalra, B., Kumar, A., Sluss, P., Oxvig, C., Hwa, V., & Dauber, A. (2020). Anthropometric and biochemical correlates of PAPP-A2, free IGF-I, and IGFBP-3 in childhood. European Journal of Endocrinology, 182(3), 363-374. https://doi.org/10.1530/EJE-19-0859

CBE

Fujimoto M, Khoury JC, Khoury PR, Kalra B, Kumar A, Sluss P, Oxvig C, Hwa V, Dauber A. 2020. Anthropometric and biochemical correlates of PAPP-A2, free IGF-I, and IGFBP-3 in childhood. European Journal of Endocrinology. 182(3):363-374. https://doi.org/10.1530/EJE-19-0859

MLA

Fujimoto, Masanobu et al. "Anthropometric and biochemical correlates of PAPP-A2, free IGF-I, and IGFBP-3 in childhood". European Journal of Endocrinology. 2020, 182(3). 363-374. https://doi.org/10.1530/EJE-19-0859

Vancouver

Fujimoto M, Khoury JC, Khoury PR, Kalra B, Kumar A, Sluss P et al. Anthropometric and biochemical correlates of PAPP-A2, free IGF-I, and IGFBP-3 in childhood. European Journal of Endocrinology. 2020;182(3):363-374. https://doi.org/10.1530/EJE-19-0859

Author

Fujimoto, Masanobu ; Khoury, Jane C. ; Khoury, Philip R. ; Kalra, Bhanu ; Kumar, Ajay ; Sluss, Patrick ; Oxvig, Claus ; Hwa, Vivian ; Dauber, Andrew. / Anthropometric and biochemical correlates of PAPP-A2, free IGF-I, and IGFBP-3 in childhood. In: European Journal of Endocrinology. 2020 ; Vol. 182, No. 3. pp. 363-374.

Bibtex

@article{d9cc0e4719e74f8d8c7ab4c547c7e47a,
title = "Anthropometric and biochemical correlates of PAPP-A2, free IGF-I, and IGFBP-3 in childhood",
abstract = "Objective: Pregnancy-associated plasma protein-A2 (PAPP-A2) is a metalloproteinase that cleaves IGFBP-3 and IGFBP-5. Human mutations in PAPPA2 result in short stature with a low percentage of free IGF-I. Little is known about PAPP-A2 levels and the regulation of free IGF-I throughout childhood. We examined PAPP-A2 and intact IGFBP-3 levels in childhood and explored associations between PAPP-A2, free and total IGF-I, and total and intact IGFBP-3 and their relationship to the percentage of free to total IGF-I and anthropometric factors. Design: Cross-sectional study at a single center. Methods: PAPP-A2, free IGF-I, and intact IGFBP-3 levels were measured in childhood (3-18 years old) and an evaluation of the relationship between these proteins and anthropometric factors. Results: In 838 children, PAPP-A2 consistently decreased throughout childhood. In contrast, free IGF-I increased. A pubertal peak in free IGF-I was present in females but was less evident in males. Intact and total IGFBP-3 increased throughout childhood; however, intact IGFBP-3 had a more marked rise than total IGFBP-3. Percent free IGF-I decreased with no distinct pubertal peak. PAPP-A2 levels positively correlated with the percent free IGF-I (Male, Female; r = 0.18, 0.38; P < 0.001) and negatively with intact IGFBP-3 (Male, Female; r = -0.58, -0.65; P < 0.0001). Conclusions: This is the first study to describe serum PAPP-A2 and intact IGFBP-3 in children between 3 and 18 years of age. Our correlative findings suggest that PAPP-A2 is an important regulator of the percent free IGF-I which can be a marker of perturbations in the GH/IGF-I axis.",
author = "Masanobu Fujimoto and Khoury, {Jane C.} and Khoury, {Philip R.} and Bhanu Kalra and Ajay Kumar and Patrick Sluss and Claus Oxvig and Vivian Hwa and Andrew Dauber",
year = "2020",
doi = "10.1530/EJE-19-0859",
language = "English",
volume = "182",
pages = "363--374",
journal = "European Journal of Endocrinology",
issn = "0804-4643",
publisher = "BioScientifica Ltd.",
number = "3",

}

RIS

TY - JOUR

T1 - Anthropometric and biochemical correlates of PAPP-A2, free IGF-I, and IGFBP-3 in childhood

AU - Fujimoto, Masanobu

AU - Khoury, Jane C.

AU - Khoury, Philip R.

AU - Kalra, Bhanu

AU - Kumar, Ajay

AU - Sluss, Patrick

AU - Oxvig, Claus

AU - Hwa, Vivian

AU - Dauber, Andrew

PY - 2020

Y1 - 2020

N2 - Objective: Pregnancy-associated plasma protein-A2 (PAPP-A2) is a metalloproteinase that cleaves IGFBP-3 and IGFBP-5. Human mutations in PAPPA2 result in short stature with a low percentage of free IGF-I. Little is known about PAPP-A2 levels and the regulation of free IGF-I throughout childhood. We examined PAPP-A2 and intact IGFBP-3 levels in childhood and explored associations between PAPP-A2, free and total IGF-I, and total and intact IGFBP-3 and their relationship to the percentage of free to total IGF-I and anthropometric factors. Design: Cross-sectional study at a single center. Methods: PAPP-A2, free IGF-I, and intact IGFBP-3 levels were measured in childhood (3-18 years old) and an evaluation of the relationship between these proteins and anthropometric factors. Results: In 838 children, PAPP-A2 consistently decreased throughout childhood. In contrast, free IGF-I increased. A pubertal peak in free IGF-I was present in females but was less evident in males. Intact and total IGFBP-3 increased throughout childhood; however, intact IGFBP-3 had a more marked rise than total IGFBP-3. Percent free IGF-I decreased with no distinct pubertal peak. PAPP-A2 levels positively correlated with the percent free IGF-I (Male, Female; r = 0.18, 0.38; P < 0.001) and negatively with intact IGFBP-3 (Male, Female; r = -0.58, -0.65; P < 0.0001). Conclusions: This is the first study to describe serum PAPP-A2 and intact IGFBP-3 in children between 3 and 18 years of age. Our correlative findings suggest that PAPP-A2 is an important regulator of the percent free IGF-I which can be a marker of perturbations in the GH/IGF-I axis.

AB - Objective: Pregnancy-associated plasma protein-A2 (PAPP-A2) is a metalloproteinase that cleaves IGFBP-3 and IGFBP-5. Human mutations in PAPPA2 result in short stature with a low percentage of free IGF-I. Little is known about PAPP-A2 levels and the regulation of free IGF-I throughout childhood. We examined PAPP-A2 and intact IGFBP-3 levels in childhood and explored associations between PAPP-A2, free and total IGF-I, and total and intact IGFBP-3 and their relationship to the percentage of free to total IGF-I and anthropometric factors. Design: Cross-sectional study at a single center. Methods: PAPP-A2, free IGF-I, and intact IGFBP-3 levels were measured in childhood (3-18 years old) and an evaluation of the relationship between these proteins and anthropometric factors. Results: In 838 children, PAPP-A2 consistently decreased throughout childhood. In contrast, free IGF-I increased. A pubertal peak in free IGF-I was present in females but was less evident in males. Intact and total IGFBP-3 increased throughout childhood; however, intact IGFBP-3 had a more marked rise than total IGFBP-3. Percent free IGF-I decreased with no distinct pubertal peak. PAPP-A2 levels positively correlated with the percent free IGF-I (Male, Female; r = 0.18, 0.38; P < 0.001) and negatively with intact IGFBP-3 (Male, Female; r = -0.58, -0.65; P < 0.0001). Conclusions: This is the first study to describe serum PAPP-A2 and intact IGFBP-3 in children between 3 and 18 years of age. Our correlative findings suggest that PAPP-A2 is an important regulator of the percent free IGF-I which can be a marker of perturbations in the GH/IGF-I axis.

UR - http://www.scopus.com/inward/record.url?scp=85079357532&partnerID=8YFLogxK

U2 - 10.1530/EJE-19-0859

DO - 10.1530/EJE-19-0859

M3 - Journal article

C2 - 31961798

AN - SCOPUS:85079357532

VL - 182

SP - 363

EP - 374

JO - European Journal of Endocrinology

JF - European Journal of Endocrinology

SN - 0804-4643

IS - 3

ER -