Analysis of vascular mechanical properties of the yellow anaconda reveals increased elasticity and distensibility of the pulmonary artery during digestion

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Analysis of vascular mechanical properties of the yellow anaconda reveals increased elasticity and distensibility of the pulmonary artery during digestion. / Filogonio, Renato; Wang, Tobias; Danielsen, Carl Christian.

In: Journal of Experimental Biology, Vol. 221, No. 16, 177766, 08.2018.

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@article{e4488f7b57c546babb85f190b533f128,
title = "Analysis of vascular mechanical properties of the yellow anaconda reveals increased elasticity and distensibility of the pulmonary artery during digestion",
abstract = "In animals with functional division of blood systemic and pulmonary pressures, such as mammals, birds, crocodilians and a few non-crocodilian reptiles, the vessel walls of systemic and pulmonary arteries are exquisitely adapted to endure different pressures during the cardiac cycle, systemic arteries being stronger and stiffer than pulmonary arteries. However, the typical non-crocodilian reptile heart possesses an undivided ventricle that provides similar systolic blood pressure to both circuits. This raises the question whether in these species the systemic and pulmonary mechanical vascular properties are similar. Snakes also display large organ plasticity and increased cardiac output in response to digestion, and we speculate how the vascular circuit would respond to this further stress. We addressed these questions by testing the mechanical vascular properties of the dorsal aorta and the right pulmonary artery of fasted and fed yellow anacondas, Eunectes notaeus, a snake without functional ventricular separation that also exhibits large metabolic and cardiovascular responses to digestion. Similar to previous studies, the dorsal aorta was thicker, stronger, stiffer and more elastic than the pulmonary artery. However, unlike any other species studied so far, the vascular distensibility (i.e. the relative volume change given a pressure change) was similar for the two circuits. Most striking, the pulmonary artery elasticity (i.e. its capacity to resume its original form after being stretched) and distensibility increased during digestion, which suggests that this circuit is remodeled to accommodate the larger stroke volume and enhance the Windkessel effect, thus providing a more constant blood perfusion during digestion.",
keywords = "Collagen, Dorsal aorta, Elastin, Postprandial period, Snakes, Sulfated glycosaminoglycans, INTRACARDIAC SHUNT PATTERNS, POSTPRANDIAL CARDIAC-HYPERTROPHY, ET-AL. 2017, PYTHON-MOLURUS, HEART-RATE, BURMESE PYTHON, STRUCTURAL FLEXIBILITY, EXTRACELLULAR-MATRIX, METABOLIC-RESPONSE, SECRETIN INFUSION",
author = "Renato Filogonio and Tobias Wang and Danielsen, {Carl Christian}",
year = "2018",
month = "8",
doi = "10.1242/jeb.177766",
language = "English",
volume = "221",
journal = "BRITISH JOURNAL OF EXPERIMENTAL BIOLOGY",
issn = "0022-0949",
publisher = "The/Company of Biologists Ltd.",
number = "16",

}

RIS

TY - JOUR

T1 - Analysis of vascular mechanical properties of the yellow anaconda reveals increased elasticity and distensibility of the pulmonary artery during digestion

AU - Filogonio, Renato

AU - Wang, Tobias

AU - Danielsen, Carl Christian

PY - 2018/8

Y1 - 2018/8

N2 - In animals with functional division of blood systemic and pulmonary pressures, such as mammals, birds, crocodilians and a few non-crocodilian reptiles, the vessel walls of systemic and pulmonary arteries are exquisitely adapted to endure different pressures during the cardiac cycle, systemic arteries being stronger and stiffer than pulmonary arteries. However, the typical non-crocodilian reptile heart possesses an undivided ventricle that provides similar systolic blood pressure to both circuits. This raises the question whether in these species the systemic and pulmonary mechanical vascular properties are similar. Snakes also display large organ plasticity and increased cardiac output in response to digestion, and we speculate how the vascular circuit would respond to this further stress. We addressed these questions by testing the mechanical vascular properties of the dorsal aorta and the right pulmonary artery of fasted and fed yellow anacondas, Eunectes notaeus, a snake without functional ventricular separation that also exhibits large metabolic and cardiovascular responses to digestion. Similar to previous studies, the dorsal aorta was thicker, stronger, stiffer and more elastic than the pulmonary artery. However, unlike any other species studied so far, the vascular distensibility (i.e. the relative volume change given a pressure change) was similar for the two circuits. Most striking, the pulmonary artery elasticity (i.e. its capacity to resume its original form after being stretched) and distensibility increased during digestion, which suggests that this circuit is remodeled to accommodate the larger stroke volume and enhance the Windkessel effect, thus providing a more constant blood perfusion during digestion.

AB - In animals with functional division of blood systemic and pulmonary pressures, such as mammals, birds, crocodilians and a few non-crocodilian reptiles, the vessel walls of systemic and pulmonary arteries are exquisitely adapted to endure different pressures during the cardiac cycle, systemic arteries being stronger and stiffer than pulmonary arteries. However, the typical non-crocodilian reptile heart possesses an undivided ventricle that provides similar systolic blood pressure to both circuits. This raises the question whether in these species the systemic and pulmonary mechanical vascular properties are similar. Snakes also display large organ plasticity and increased cardiac output in response to digestion, and we speculate how the vascular circuit would respond to this further stress. We addressed these questions by testing the mechanical vascular properties of the dorsal aorta and the right pulmonary artery of fasted and fed yellow anacondas, Eunectes notaeus, a snake without functional ventricular separation that also exhibits large metabolic and cardiovascular responses to digestion. Similar to previous studies, the dorsal aorta was thicker, stronger, stiffer and more elastic than the pulmonary artery. However, unlike any other species studied so far, the vascular distensibility (i.e. the relative volume change given a pressure change) was similar for the two circuits. Most striking, the pulmonary artery elasticity (i.e. its capacity to resume its original form after being stretched) and distensibility increased during digestion, which suggests that this circuit is remodeled to accommodate the larger stroke volume and enhance the Windkessel effect, thus providing a more constant blood perfusion during digestion.

KW - Collagen

KW - Dorsal aorta

KW - Elastin

KW - Postprandial period

KW - Snakes

KW - Sulfated glycosaminoglycans

KW - INTRACARDIAC SHUNT PATTERNS

KW - POSTPRANDIAL CARDIAC-HYPERTROPHY

KW - ET-AL. 2017

KW - PYTHON-MOLURUS

KW - HEART-RATE

KW - BURMESE PYTHON

KW - STRUCTURAL FLEXIBILITY

KW - EXTRACELLULAR-MATRIX

KW - METABOLIC-RESPONSE

KW - SECRETIN INFUSION

U2 - 10.1242/jeb.177766

DO - 10.1242/jeb.177766

M3 - Journal article

VL - 221

JO - BRITISH JOURNAL OF EXPERIMENTAL BIOLOGY

JF - BRITISH JOURNAL OF EXPERIMENTAL BIOLOGY

SN - 0022-0949

IS - 16

M1 - 177766

ER -