Department of Economics and Business Economics

Analysis of shared heritability in common disorders of the brain

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Analysis of shared heritability in common disorders of the brain. / Brainstorm Consortium.

In: Science, Vol. 360, No. 6395, 8757, 22.06.2018, p. eaap8757.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Brainstorm Consortium 2018, 'Analysis of shared heritability in common disorders of the brain', Science, vol. 360, no. 6395, 8757, pp. eaap8757. https://doi.org/10.1126/science.aap8757

APA

Brainstorm Consortium (2018). Analysis of shared heritability in common disorders of the brain. Science, 360(6395), eaap8757. [8757]. https://doi.org/10.1126/science.aap8757

CBE

MLA

Vancouver

Brainstorm Consortium. Analysis of shared heritability in common disorders of the brain. Science. 2018 Jun 22;360(6395):eaap8757. 8757. https://doi.org/10.1126/science.aap8757

Author

Brainstorm Consortium. / Analysis of shared heritability in common disorders of the brain. In: Science. 2018 ; Vol. 360, No. 6395. pp. eaap8757.

Bibtex

@article{f2dd2d6a60304cf182d6d02892380e40,
title = "Analysis of shared heritability in common disorders of the brain",
abstract = "Disorders of the brain can exhibit considerable epidemiological comorbidity and often share symptoms, provoking debate about their etiologic overlap. We quantified the genetic sharing of 25 brain disorders from genome-wide association studies of 265,218 patients and 784,643 control participants and assessed their relationship to 17 phenotypes from 1,191,588 individuals. Psychiatric disorders share common variant risk, whereas neurological disorders appear more distinct from one another and from the psychiatric disorders. We also identified significant sharing between disorders and a number of brain phenotypes, including cognitive measures. Further, we conducted simulations to explore how statistical power, diagnostic misclassification, and phenotypic heterogeneity affect genetic correlations. These results highlight the importance of common genetic variation as a risk factor for brain disorders and the value of heritability-based methods in understanding their etiology.",
keywords = "Brain Diseases/classification, Genetic Variation, Genome-Wide Association Study, Humans, Mental Disorders/classification, Phenotype, Quantitative Trait, Heritable, Risk Factors",
author = "Verneri Anttila and Brendan Bulik-Sullivan and Finucane, {Hilary K} and Walters, {Raymond K} and Jose Bras and Laramie Duncan and Valentina Escott-Price and Falcone, {Guido J} and Padhraig Gormley and Rainer Malik and Patsopoulos, {Nikolaos A} and Stephan Ripke and Zhi Wei and Dongmei Yu and Lee, {Phil H} and Patrick Turley and Benjamin Grenier-Boley and Vincent Chouraki and Yoichiro Kamatani and Claudine Berr and Luc Letenneur and Didier Hannequin and Philippe Amouyel and Anne Boland and Jean-Fran{\cc}ois Deleuze and Emmanuelle Duron and Vardarajan, {Badri N} and Christiane Reitz and Goate, {Alison M} and Huentelman, {Matthew J} and Kamboh, {M Ilyas} and Larson, {Eric B} and Ekaterina Rogaeva and {St George-Hyslop}, Peter and Hakon Hakonarson and Kukull, {Walter A} and Farrer, {Lindsay A} and Barnes, {Lisa L} and Beach, {Thomas G} and Demirci, {F Yesim} and Elizabeth Head and Hulette, {Christine M} and Jicha, {Gregory A} and Kauwe, {John S K} and Thomas Hansen and Wei-Min Chen and S{\o}ren Dalsgaard and B{\o}rglum, {Anders D} and Jakob Grove and Manuel Mattheisen and {Brainstorm Consortium}",
note = "Copyright {\circledC} 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.",
year = "2018",
month = "6",
day = "22",
doi = "10.1126/science.aap8757",
language = "English",
volume = "360",
pages = "eaap8757",
journal = "Science",
issn = "0036-8075",
publisher = "AMER ASSOC ADVANCEMENT SCIENCE",
number = "6395",

}

RIS

TY - JOUR

T1 - Analysis of shared heritability in common disorders of the brain

AU - Anttila, Verneri

AU - Bulik-Sullivan, Brendan

AU - Finucane, Hilary K

AU - Walters, Raymond K

AU - Bras, Jose

AU - Duncan, Laramie

AU - Escott-Price, Valentina

AU - Falcone, Guido J

AU - Gormley, Padhraig

AU - Malik, Rainer

AU - Patsopoulos, Nikolaos A

AU - Ripke, Stephan

AU - Wei, Zhi

AU - Yu, Dongmei

AU - Lee, Phil H

AU - Turley, Patrick

AU - Grenier-Boley, Benjamin

AU - Chouraki, Vincent

AU - Kamatani, Yoichiro

AU - Berr, Claudine

AU - Letenneur, Luc

AU - Hannequin, Didier

AU - Amouyel, Philippe

AU - Boland, Anne

AU - Deleuze, Jean-François

AU - Duron, Emmanuelle

AU - Vardarajan, Badri N

AU - Reitz, Christiane

AU - Goate, Alison M

AU - Huentelman, Matthew J

AU - Kamboh, M Ilyas

AU - Larson, Eric B

AU - Rogaeva, Ekaterina

AU - St George-Hyslop, Peter

AU - Hakonarson, Hakon

AU - Kukull, Walter A

AU - Farrer, Lindsay A

AU - Barnes, Lisa L

AU - Beach, Thomas G

AU - Demirci, F Yesim

AU - Head, Elizabeth

AU - Hulette, Christine M

AU - Jicha, Gregory A

AU - Kauwe, John S K

AU - Hansen, Thomas

AU - Chen, Wei-Min

AU - Dalsgaard, Søren

AU - Børglum, Anders D

AU - Grove, Jakob

AU - Mattheisen, Manuel

AU - Brainstorm Consortium

N1 - Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

PY - 2018/6/22

Y1 - 2018/6/22

N2 - Disorders of the brain can exhibit considerable epidemiological comorbidity and often share symptoms, provoking debate about their etiologic overlap. We quantified the genetic sharing of 25 brain disorders from genome-wide association studies of 265,218 patients and 784,643 control participants and assessed their relationship to 17 phenotypes from 1,191,588 individuals. Psychiatric disorders share common variant risk, whereas neurological disorders appear more distinct from one another and from the psychiatric disorders. We also identified significant sharing between disorders and a number of brain phenotypes, including cognitive measures. Further, we conducted simulations to explore how statistical power, diagnostic misclassification, and phenotypic heterogeneity affect genetic correlations. These results highlight the importance of common genetic variation as a risk factor for brain disorders and the value of heritability-based methods in understanding their etiology.

AB - Disorders of the brain can exhibit considerable epidemiological comorbidity and often share symptoms, provoking debate about their etiologic overlap. We quantified the genetic sharing of 25 brain disorders from genome-wide association studies of 265,218 patients and 784,643 control participants and assessed their relationship to 17 phenotypes from 1,191,588 individuals. Psychiatric disorders share common variant risk, whereas neurological disorders appear more distinct from one another and from the psychiatric disorders. We also identified significant sharing between disorders and a number of brain phenotypes, including cognitive measures. Further, we conducted simulations to explore how statistical power, diagnostic misclassification, and phenotypic heterogeneity affect genetic correlations. These results highlight the importance of common genetic variation as a risk factor for brain disorders and the value of heritability-based methods in understanding their etiology.

KW - Brain Diseases/classification

KW - Genetic Variation

KW - Genome-Wide Association Study

KW - Humans

KW - Mental Disorders/classification

KW - Phenotype

KW - Quantitative Trait, Heritable

KW - Risk Factors

UR - http://www.scopus.com/inward/record.url?scp=85049284114&partnerID=8YFLogxK

U2 - 10.1126/science.aap8757

DO - 10.1126/science.aap8757

M3 - Journal article

C2 - 29930110

VL - 360

SP - eaap8757

JO - Science

JF - Science

SN - 0036-8075

IS - 6395

M1 - 8757

ER -