Analysing the distribution of synaptic vesicles using a spatial point process model

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperConference articleResearchpeer-review

DOI

  • Mahdieh Khanmohammadi, Københavns Universitet
  • ,
  • Rasmus Waagepetersen, Aalborg University
  • ,
  • Nicoletta Nava
  • ,
  • Jens Nyengaard
  • Jon Sporring, Københavns Universitet

Stress can affect the brain functionality in many ways. As the synaptic vesicles have a major role in nervous signal transportation in synapses, their distribution in relationship to the active zone is very important in studying the neuron responses. We study the effect of stress on brain functionality by statistically modelling the distribution of the synaptic vesicles in two groups of rats: A control group subjected to sham stress and a stressed group subjected to a single acute foot-shock (FS)-stress episode. We hypothesize that the synaptic vesicles have different spatial distributions in the two groups. The spatial distributions are modelled using spatial point process models with an inhomogeneous conditional intensity and repulsive pairwise interactions. Our results verify the hypothesis that the two groups have different spatial distributions.

Original languageEnglish
JournalACM BCB 2014 - 5th ACM Conference on Bioinformatics, Computational Biology, and Health Informatics
Pages (from-to)73-78
Number of pages6
DOIs
Publication statusPublished - 20 Sep 2014
Event5th ACM Conference on Bioinformatics, Computational Biology, and Health Informatics, ACM BCB 2014 - Newport Beach, United States
Duration: 20 Sep 201423 Sep 2014

Conference

Conference5th ACM Conference on Bioinformatics, Computational Biology, and Health Informatics, ACM BCB 2014
CountryUnited States
CityNewport Beach
Period20/09/201423/09/2014
SponsorACM Special Interest Group on Biomedical Computing (SIGBIO)

See relations at Aarhus University Citationformats

ID: 156882729