Analysing the distribution of synaptic vesicles using a spatial point process model

Mahdieh Khanmohammadi; Rasmus Waagepetersen; Nicoletta Nava; Jens Nyengaard; Jon Sporring

doi:10.1145/2649387.2649404

Analysing the distribution of synaptic vesicles using a spatial point process model

Mahdieh Khanmohammadi^*, Rasmus Waagepetersen, Nicoletta Nava, Jens Nyengaard, Jon Sporring

^*Corresponding author for this work

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Conference article › Research › peer-review

4 Citations (Scopus)

Abstract

Stress can affect the brain functionality in many ways. As the synaptic vesicles have a major role in nervous signal transportation in synapses, their distribution in relationship to the active zone is very important in studying the neuron responses. We study the effect of stress on brain functionality by statistically modelling the distribution of the synaptic vesicles in two groups of rats: A control group subjected to sham stress and a stressed group subjected to a single acute foot-shock (FS)-stress episode. We hypothesize that the synaptic vesicles have different spatial distributions in the two groups. The spatial distributions are modelled using spatial point process models with an inhomogeneous conditional intensity and repulsive pairwise interactions. Our results verify the hypothesis that the two groups have different spatial distributions.

Original language	English
Journal	-
Pages (from-to)	73-78
Number of pages	6
DOIs	https://doi.org/10.1145/2649387.2649404
Publication status	Published - 20 Sept 2014
Event	5th ACM Conference on Bioinformatics, Computational Biology, and Health Informatics, ACM BCB 2014 - Newport Beach, United States Duration: 20 Sept 2014 → 23 Sept 2014

Conference

Conference	5th ACM Conference on Bioinformatics, Computational Biology, and Health Informatics, ACM BCB 2014
Country/Territory	United States
City	Newport Beach
Period	20/09/2014 → 23/09/2014

Access to Document

10.1145/2649387.2649404

Cite this

@inproceedings{f5f762be25a04f4faa00d59b10a808d2,

title = "Analysing the distribution of synaptic vesicles using a spatial point process model",

abstract = "Stress can affect the brain functionality in many ways. As the synaptic vesicles have a major role in nervous signal transportation in synapses, their distribution in relationship to the active zone is very important in studying the neuron responses. We study the effect of stress on brain functionality by statistically modelling the distribution of the synaptic vesicles in two groups of rats: A control group subjected to sham stress and a stressed group subjected to a single acute foot-shock (FS)-stress episode. We hypothesize that the synaptic vesicles have different spatial distributions in the two groups. The spatial distributions are modelled using spatial point process models with an inhomogeneous conditional intensity and repulsive pairwise interactions. Our results verify the hypothesis that the two groups have different spatial distributions.",

author = "Mahdieh Khanmohammadi and Rasmus Waagepetersen and Nicoletta Nava and Jens Nyengaard and Jon Sporring",

year = "2014",

month = sep,

day = "20",

doi = "10.1145/2649387.2649404",

language = "English",

pages = "73--78",

journal = "-",

publisher = "Tjele: Danish Institute of Agricultural Sciences, Research Centre Foulum",

note = "5th ACM Conference on Bioinformatics, Computational Biology, and Health Informatics, ACM BCB 2014 ; Conference date: 20-09-2014 Through 23-09-2014",

}

TY - GEN

T1 - Analysing the distribution of synaptic vesicles using a spatial point process model

AU - Khanmohammadi, Mahdieh

AU - Waagepetersen, Rasmus

AU - Nava, Nicoletta

AU - Nyengaard, Jens

AU - Sporring, Jon

PY - 2014/9/20

Y1 - 2014/9/20

N2 - Stress can affect the brain functionality in many ways. As the synaptic vesicles have a major role in nervous signal transportation in synapses, their distribution in relationship to the active zone is very important in studying the neuron responses. We study the effect of stress on brain functionality by statistically modelling the distribution of the synaptic vesicles in two groups of rats: A control group subjected to sham stress and a stressed group subjected to a single acute foot-shock (FS)-stress episode. We hypothesize that the synaptic vesicles have different spatial distributions in the two groups. The spatial distributions are modelled using spatial point process models with an inhomogeneous conditional intensity and repulsive pairwise interactions. Our results verify the hypothesis that the two groups have different spatial distributions.

AB - Stress can affect the brain functionality in many ways. As the synaptic vesicles have a major role in nervous signal transportation in synapses, their distribution in relationship to the active zone is very important in studying the neuron responses. We study the effect of stress on brain functionality by statistically modelling the distribution of the synaptic vesicles in two groups of rats: A control group subjected to sham stress and a stressed group subjected to a single acute foot-shock (FS)-stress episode. We hypothesize that the synaptic vesicles have different spatial distributions in the two groups. The spatial distributions are modelled using spatial point process models with an inhomogeneous conditional intensity and repulsive pairwise interactions. Our results verify the hypothesis that the two groups have different spatial distributions.

UR - http://www.scopus.com/inward/record.url?scp=84920722855&partnerID=8YFLogxK

U2 - 10.1145/2649387.2649404

DO - 10.1145/2649387.2649404

M3 - Conference article

AN - SCOPUS:84920722855

SP - 73

EP - 78

JO - -

JF - -

T2 - 5th ACM Conference on Bioinformatics, Computational Biology, and Health Informatics, ACM BCB 2014

Y2 - 20 September 2014 through 23 September 2014

ER -

Analysing the distribution of synaptic vesicles using a spatial point process model

Abstract

Conference

Access to Document

Other files and links

Fingerprint

Cite this