An update to polyketide synthase and non-ribosomal synthetase genes and nomenclature in Fusarium

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An update to polyketide synthase and non-ribosomal synthetase genes and nomenclature in Fusarium. / Hansen, Frederik T; Gardiner, Donald M; Lysøe, Erik; Fuertes, Patricia Romans; Tudzynski, Bettina; Wiemann, Philipp; Sondergaard, Teis Esben; Giese, Henriette; Brodersen, Ditlev E.; Sørensen, Jens Laurids.

In: Fungal Genetics and Biology, Vol. 75, 02.2015, p. 20-29.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Hansen, FT, Gardiner, DM, Lysøe, E, Fuertes, PR, Tudzynski, B, Wiemann, P, Sondergaard, TE, Giese, H, Brodersen, DE & Sørensen, JL 2015, 'An update to polyketide synthase and non-ribosomal synthetase genes and nomenclature in Fusarium', Fungal Genetics and Biology, vol. 75, pp. 20-29. https://doi.org/10.1016/j.fgb.2014.12.004

APA

Hansen, F. T., Gardiner, D. M., Lysøe, E., Fuertes, P. R., Tudzynski, B., Wiemann, P., Sondergaard, T. E., Giese, H., Brodersen, D. E., & Sørensen, J. L. (2015). An update to polyketide synthase and non-ribosomal synthetase genes and nomenclature in Fusarium. Fungal Genetics and Biology, 75, 20-29. https://doi.org/10.1016/j.fgb.2014.12.004

CBE

Hansen FT, Gardiner DM, Lysøe E, Fuertes PR, Tudzynski B, Wiemann P, Sondergaard TE, Giese H, Brodersen DE, Sørensen JL. 2015. An update to polyketide synthase and non-ribosomal synthetase genes and nomenclature in Fusarium. Fungal Genetics and Biology. 75:20-29. https://doi.org/10.1016/j.fgb.2014.12.004

MLA

Vancouver

Hansen FT, Gardiner DM, Lysøe E, Fuertes PR, Tudzynski B, Wiemann P et al. An update to polyketide synthase and non-ribosomal synthetase genes and nomenclature in Fusarium. Fungal Genetics and Biology. 2015 Feb;75:20-29. https://doi.org/10.1016/j.fgb.2014.12.004

Author

Hansen, Frederik T ; Gardiner, Donald M ; Lysøe, Erik ; Fuertes, Patricia Romans ; Tudzynski, Bettina ; Wiemann, Philipp ; Sondergaard, Teis Esben ; Giese, Henriette ; Brodersen, Ditlev E. ; Sørensen, Jens Laurids. / An update to polyketide synthase and non-ribosomal synthetase genes and nomenclature in Fusarium. In: Fungal Genetics and Biology. 2015 ; Vol. 75. pp. 20-29.

Bibtex

@article{0a32c916d01f46ceb3eed99af8adb16b,
title = "An update to polyketide synthase and non-ribosomal synthetase genes and nomenclature in Fusarium",
abstract = "Members of the genus Fusarium produce a plethora of bioactive secondary metabolites, which can be harmful to humans and animals or have potential in drug development. In this study we have performed comparative analyses of polyketide synthases (PKSs) and non-ribosomal peptide synthetases (NRPSs) from ten different Fusarium species including F. graminearum (two strains), F. verticillioides, F. solani, F. culmorum, F. pseudograminearum, F. fujikuroi, F. acuminatum, F. avenaceum, F. equiseti, and F. oxysporum (12 strains). This led to identification of 52 NRPS and 52 PKSs orthology groups, respectively, and although not all PKSs and NRPSs are assumed to be intact or functional, the analyses illustrate the huge secondary metabolite potential in Fusarium. In our analyses we identified a core collection of eight NRPSs (NRPS2-4, 6, 10-13) and two PKSs (PKS3 and PKS7) that are conserved in all strains analyzed in this study. The identified PKSs and NRPSs were named based on a previously developed classification system (www.FusariumNRPSPKS.dk). We suggest this system be used when PKSs and NRPSs have to be classified in future sequenced Fusarium strains. This system will facilitate identification of orthologous and non-orthologous NRPSs and PKSs from newly sequenced Fusarium genomes and will aid the scientific community by providing a common nomenclature for these two groups of genes/enzymes.",
author = "Hansen, {Frederik T} and Gardiner, {Donald M} and Erik Lys{\o}e and Fuertes, {Patricia Romans} and Bettina Tudzynski and Philipp Wiemann and Sondergaard, {Teis Esben} and Henriette Giese and Brodersen, {Ditlev E.} and S{\o}rensen, {Jens Laurids}",
note = "Copyright {\textcopyright} 2014. Published by Elsevier Inc.",
year = "2015",
month = feb,
doi = "10.1016/j.fgb.2014.12.004",
language = "English",
volume = "75",
pages = "20--29",
journal = "Fungal Genetics and Biology",
issn = "1087-1845",
publisher = "Academic Press",

}

RIS

TY - JOUR

T1 - An update to polyketide synthase and non-ribosomal synthetase genes and nomenclature in Fusarium

AU - Hansen, Frederik T

AU - Gardiner, Donald M

AU - Lysøe, Erik

AU - Fuertes, Patricia Romans

AU - Tudzynski, Bettina

AU - Wiemann, Philipp

AU - Sondergaard, Teis Esben

AU - Giese, Henriette

AU - Brodersen, Ditlev E.

AU - Sørensen, Jens Laurids

N1 - Copyright © 2014. Published by Elsevier Inc.

PY - 2015/2

Y1 - 2015/2

N2 - Members of the genus Fusarium produce a plethora of bioactive secondary metabolites, which can be harmful to humans and animals or have potential in drug development. In this study we have performed comparative analyses of polyketide synthases (PKSs) and non-ribosomal peptide synthetases (NRPSs) from ten different Fusarium species including F. graminearum (two strains), F. verticillioides, F. solani, F. culmorum, F. pseudograminearum, F. fujikuroi, F. acuminatum, F. avenaceum, F. equiseti, and F. oxysporum (12 strains). This led to identification of 52 NRPS and 52 PKSs orthology groups, respectively, and although not all PKSs and NRPSs are assumed to be intact or functional, the analyses illustrate the huge secondary metabolite potential in Fusarium. In our analyses we identified a core collection of eight NRPSs (NRPS2-4, 6, 10-13) and two PKSs (PKS3 and PKS7) that are conserved in all strains analyzed in this study. The identified PKSs and NRPSs were named based on a previously developed classification system (www.FusariumNRPSPKS.dk). We suggest this system be used when PKSs and NRPSs have to be classified in future sequenced Fusarium strains. This system will facilitate identification of orthologous and non-orthologous NRPSs and PKSs from newly sequenced Fusarium genomes and will aid the scientific community by providing a common nomenclature for these two groups of genes/enzymes.

AB - Members of the genus Fusarium produce a plethora of bioactive secondary metabolites, which can be harmful to humans and animals or have potential in drug development. In this study we have performed comparative analyses of polyketide synthases (PKSs) and non-ribosomal peptide synthetases (NRPSs) from ten different Fusarium species including F. graminearum (two strains), F. verticillioides, F. solani, F. culmorum, F. pseudograminearum, F. fujikuroi, F. acuminatum, F. avenaceum, F. equiseti, and F. oxysporum (12 strains). This led to identification of 52 NRPS and 52 PKSs orthology groups, respectively, and although not all PKSs and NRPSs are assumed to be intact or functional, the analyses illustrate the huge secondary metabolite potential in Fusarium. In our analyses we identified a core collection of eight NRPSs (NRPS2-4, 6, 10-13) and two PKSs (PKS3 and PKS7) that are conserved in all strains analyzed in this study. The identified PKSs and NRPSs were named based on a previously developed classification system (www.FusariumNRPSPKS.dk). We suggest this system be used when PKSs and NRPSs have to be classified in future sequenced Fusarium strains. This system will facilitate identification of orthologous and non-orthologous NRPSs and PKSs from newly sequenced Fusarium genomes and will aid the scientific community by providing a common nomenclature for these two groups of genes/enzymes.

U2 - 10.1016/j.fgb.2014.12.004

DO - 10.1016/j.fgb.2014.12.004

M3 - Journal article

C2 - 25543026

VL - 75

SP - 20

EP - 29

JO - Fungal Genetics and Biology

JF - Fungal Genetics and Biology

SN - 1087-1845

ER -