An Intracortical Implantable Brain-Computer Interface for Telemetric Real-Time Recording and Manipulation of Neuronal Circuits for Closed-Loop Intervention

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Standard

An Intracortical Implantable Brain-Computer Interface for Telemetric Real-Time Recording and Manipulation of Neuronal Circuits for Closed-Loop Intervention. / Zaer, Hamed; Deshmukh, Ashlesha; Orlowski, Dariusz; Fan, Wei; Prouvot, Pierre-Hugues; Glud, Andreas Nørgaard; Jensen, Morten Bjørn; Worm, Esben Schjødt; Lukacova, Slávka; Mikkelsen, Trine Werenberg; Fitting, Lise Moberg; Adler, John R; Schneider, M Bret; Jensen, Martin Snejbjerg; Fu, Quanhai; Go, Vinson; Morizio, James; Sørensen, Jens Christian Hedemann; Stroh, Albrecht.

In: Frontiers in Human Neuroscience, Vol. 15, 618626, 2021.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

APA

CBE

MLA

Vancouver

Author

Bibtex

@article{35d15b467ba94e7f8a972908d7de5ede,
title = "An Intracortical Implantable Brain-Computer Interface for Telemetric Real-Time Recording and Manipulation of Neuronal Circuits for Closed-Loop Intervention",
abstract = "Recording and manipulating neuronal ensemble activity is a key requirement in advanced neuromodulatory and behavior studies. Devices capable of both recording and manipulating neuronal activity brain-computer interfaces (BCIs) should ideally operate un-tethered and allow chronic longitudinal manipulations in the freely moving animal. In this study, we designed a new intracortical BCI feasible of telemetric recording and stimulating local gray and white matter of visual neural circuit after irradiation exposure. To increase the translational reliance, we put forward a G{\"o}ttingen minipig model. The animal was stereotactically irradiated at the level of the visual cortex upon defining the target by a fused cerebral MRI and CT scan. A fully implantable neural telemetry system consisting of a 64 channel intracortical multielectrode array, a telemetry capsule, and an inductive rechargeable battery was then implanted into the visual cortex to record and manipulate local field potentials, and multi-unit activity. We achieved a 3-month stability of the functionality of the un-tethered BCI in terms of telemetric radio-communication, inductive battery charging, and device biocompatibility for 3 months. Finally, we could reliably record the local signature of sub- and suprathreshold neuronal activity in the visual cortex with high bandwidth without complications. The ability to wireless induction charging combined with the entirely implantable design, the rather high recording bandwidth, and the ability to record and stimulate simultaneously put forward a wireless BCI capable of long-term un-tethered real-time communication for causal preclinical circuit-based closed-loop interventions.",
author = "Hamed Zaer and Ashlesha Deshmukh and Dariusz Orlowski and Wei Fan and Pierre-Hugues Prouvot and Glud, {Andreas N{\o}rgaard} and Jensen, {Morten Bj{\o}rn} and Worm, {Esben Schj{\o}dt} and Sl{\'a}vka Lukacova and Mikkelsen, {Trine Werenberg} and Fitting, {Lise Moberg} and Adler, {John R} and Schneider, {M Bret} and Jensen, {Martin Snejbjerg} and Quanhai Fu and Vinson Go and James Morizio and S{\o}rensen, {Jens Christian Hedemann} and Albrecht Stroh",
note = "Copyright {\textcopyright} 2021 Zaer, Deshmukh, Orlowski, Fan, Prouvot, Glud, Jensen, Worm, Lukacova, Mikkelsen, Fitting, Adler, Schneider, Jensen, Fu, Go, Morizio, S{\o}rensen and Stroh.",
year = "2021",
doi = "10.3389/fnhum.2021.618626",
language = "English",
volume = "15",
journal = "Frontiers in Human Neuroscience",
issn = "1662-5161",
publisher = "Frontiers Research Foundation",

}

RIS

TY - JOUR

T1 - An Intracortical Implantable Brain-Computer Interface for Telemetric Real-Time Recording and Manipulation of Neuronal Circuits for Closed-Loop Intervention

AU - Zaer, Hamed

AU - Deshmukh, Ashlesha

AU - Orlowski, Dariusz

AU - Fan, Wei

AU - Prouvot, Pierre-Hugues

AU - Glud, Andreas Nørgaard

AU - Jensen, Morten Bjørn

AU - Worm, Esben Schjødt

AU - Lukacova, Slávka

AU - Mikkelsen, Trine Werenberg

AU - Fitting, Lise Moberg

AU - Adler, John R

AU - Schneider, M Bret

AU - Jensen, Martin Snejbjerg

AU - Fu, Quanhai

AU - Go, Vinson

AU - Morizio, James

AU - Sørensen, Jens Christian Hedemann

AU - Stroh, Albrecht

N1 - Copyright © 2021 Zaer, Deshmukh, Orlowski, Fan, Prouvot, Glud, Jensen, Worm, Lukacova, Mikkelsen, Fitting, Adler, Schneider, Jensen, Fu, Go, Morizio, Sørensen and Stroh.

PY - 2021

Y1 - 2021

N2 - Recording and manipulating neuronal ensemble activity is a key requirement in advanced neuromodulatory and behavior studies. Devices capable of both recording and manipulating neuronal activity brain-computer interfaces (BCIs) should ideally operate un-tethered and allow chronic longitudinal manipulations in the freely moving animal. In this study, we designed a new intracortical BCI feasible of telemetric recording and stimulating local gray and white matter of visual neural circuit after irradiation exposure. To increase the translational reliance, we put forward a Göttingen minipig model. The animal was stereotactically irradiated at the level of the visual cortex upon defining the target by a fused cerebral MRI and CT scan. A fully implantable neural telemetry system consisting of a 64 channel intracortical multielectrode array, a telemetry capsule, and an inductive rechargeable battery was then implanted into the visual cortex to record and manipulate local field potentials, and multi-unit activity. We achieved a 3-month stability of the functionality of the un-tethered BCI in terms of telemetric radio-communication, inductive battery charging, and device biocompatibility for 3 months. Finally, we could reliably record the local signature of sub- and suprathreshold neuronal activity in the visual cortex with high bandwidth without complications. The ability to wireless induction charging combined with the entirely implantable design, the rather high recording bandwidth, and the ability to record and stimulate simultaneously put forward a wireless BCI capable of long-term un-tethered real-time communication for causal preclinical circuit-based closed-loop interventions.

AB - Recording and manipulating neuronal ensemble activity is a key requirement in advanced neuromodulatory and behavior studies. Devices capable of both recording and manipulating neuronal activity brain-computer interfaces (BCIs) should ideally operate un-tethered and allow chronic longitudinal manipulations in the freely moving animal. In this study, we designed a new intracortical BCI feasible of telemetric recording and stimulating local gray and white matter of visual neural circuit after irradiation exposure. To increase the translational reliance, we put forward a Göttingen minipig model. The animal was stereotactically irradiated at the level of the visual cortex upon defining the target by a fused cerebral MRI and CT scan. A fully implantable neural telemetry system consisting of a 64 channel intracortical multielectrode array, a telemetry capsule, and an inductive rechargeable battery was then implanted into the visual cortex to record and manipulate local field potentials, and multi-unit activity. We achieved a 3-month stability of the functionality of the un-tethered BCI in terms of telemetric radio-communication, inductive battery charging, and device biocompatibility for 3 months. Finally, we could reliably record the local signature of sub- and suprathreshold neuronal activity in the visual cortex with high bandwidth without complications. The ability to wireless induction charging combined with the entirely implantable design, the rather high recording bandwidth, and the ability to record and stimulate simultaneously put forward a wireless BCI capable of long-term un-tethered real-time communication for causal preclinical circuit-based closed-loop interventions.

U2 - 10.3389/fnhum.2021.618626

DO - 10.3389/fnhum.2021.618626

M3 - Journal article

C2 - 33613212

VL - 15

JO - Frontiers in Human Neuroscience

JF - Frontiers in Human Neuroscience

SN - 1662-5161

M1 - 618626

ER -