An fMRI study on the groove experience in Parkinson's disease

TY - CONF

T1 - An fMRI study on the groove experience in Parkinson's disease

AU - Pando-Naude, Victor

AU - Matthews, Tomas

AU - Højlund, Andreas

AU - Johnsen, Erik

AU - Garza Villarreal, Eduardo

AU - Witek, Maria

AU - Heggli, Ole

AU - Kleber, Boris

AU - Penhune, Virginia

AU - Vuust, Peter

PY - 2023

Y1 - 2023

N2 - Music activates brain regions associated with pleasure and reward and can create an impulse to move in time with the beat. This study tested the hypothesis that the pleasurable urge to move to music (PLUMM), often referred to as a groove experience, relies on the interaction between auditory, motor, and reward regions in the brain, with the basal ganglia (BG) loops playing a central role. Brain functional connectivity (FC) of healthy controls (HC) and participants with Parkinson's disease (PD), a movement disorder resulting from dopaminergic dysfunctions in the BG, was compared using fMRI. Participants listened to musical sequences with varying rhythmic complexity (isochronous, low, medium, high) and rated their experienced PLUMM. FC correlates were analyzed as a function of each rhythmic condition using generalized psychophysiological interactions with a seed-based approach. Behaviorally, HC preferred medium complexity, while PD preferred low. Regarding FC, HC showed significant correlations exclusively between auditory areas within and between hemispheres while listening to isochronous and high complexity rhythms. While listening to low and medium complexities, HC showed additional correlations between auditory cortices and supplementary motor areas, stronger with medium. PD participants showed significant correlations only between posterior auditory cortices during isochronous rhythms. Low and medium complexities in PD also showed correlations between auditory cortices and supplementary motor area, stronger with low. High complexity in PD showed anticorrelated FC between auditory, sensorimotor, and cingulate cortices. These results support models implicating dopamine in PLUMM and suggest that dopamine dysregulation within cortico-striatal circuits disrupts beat-and meter-based predictive processes.

AB - Music activates brain regions associated with pleasure and reward and can create an impulse to move in time with the beat. This study tested the hypothesis that the pleasurable urge to move to music (PLUMM), often referred to as a groove experience, relies on the interaction between auditory, motor, and reward regions in the brain, with the basal ganglia (BG) loops playing a central role. Brain functional connectivity (FC) of healthy controls (HC) and participants with Parkinson's disease (PD), a movement disorder resulting from dopaminergic dysfunctions in the BG, was compared using fMRI. Participants listened to musical sequences with varying rhythmic complexity (isochronous, low, medium, high) and rated their experienced PLUMM. FC correlates were analyzed as a function of each rhythmic condition using generalized psychophysiological interactions with a seed-based approach. Behaviorally, HC preferred medium complexity, while PD preferred low. Regarding FC, HC showed significant correlations exclusively between auditory areas within and between hemispheres while listening to isochronous and high complexity rhythms. While listening to low and medium complexities, HC showed additional correlations between auditory cortices and supplementary motor areas, stronger with medium. PD participants showed significant correlations only between posterior auditory cortices during isochronous rhythms. Low and medium complexities in PD also showed correlations between auditory cortices and supplementary motor area, stronger with low. High complexity in PD showed anticorrelated FC between auditory, sensorimotor, and cingulate cortices. These results support models implicating dopamine in PLUMM and suggest that dopamine dysregulation within cortico-striatal circuits disrupts beat-and meter-based predictive processes.

U2 - 10.13140/RG.2.2.23884.18561

DO - 10.13140/RG.2.2.23884.18561

M3 - Paper

T2 - Interntational Conference of Music Perception and Cognition ICMPC17-APSCOM

Y2 - 24 August 2023 through 28 August 2023

ER -