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An extensive pattern of atypical neural speech-sound discrimination in newborns at risk of dyslexia

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An extensive pattern of atypical neural speech-sound discrimination in newborns at risk of dyslexia. / Thiede, Anja; Virtala, Paula; Ala-Kurikka, Iina; Partanen, Eino; Huotilainen, Minna; Mikkola, Kaija; Leppänen, Paavo; Kujala, Teija.

In: Clinical Neurophysiology, Vol. 130, No. 5, 05.2019, p. 634-646.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Thiede, A, Virtala, P, Ala-Kurikka, I, Partanen, E, Huotilainen, M, Mikkola, K, Leppänen, P & Kujala, T 2019, 'An extensive pattern of atypical neural speech-sound discrimination in newborns at risk of dyslexia' Clinical Neurophysiology, vol. 130, no. 5, pp. 634-646. https://doi.org/10.1016/j.clinph.2019.01.019

APA

Thiede, A., Virtala, P., Ala-Kurikka, I., Partanen, E., Huotilainen, M., Mikkola, K., ... Kujala, T. (2019). An extensive pattern of atypical neural speech-sound discrimination in newborns at risk of dyslexia. Clinical Neurophysiology, 130(5), 634-646. https://doi.org/10.1016/j.clinph.2019.01.019

CBE

Thiede A, Virtala P, Ala-Kurikka I, Partanen E, Huotilainen M, Mikkola K, Leppänen P, Kujala T. 2019. An extensive pattern of atypical neural speech-sound discrimination in newborns at risk of dyslexia. Clinical Neurophysiology. 130(5):634-646. https://doi.org/10.1016/j.clinph.2019.01.019

MLA

Vancouver

Thiede A, Virtala P, Ala-Kurikka I, Partanen E, Huotilainen M, Mikkola K et al. An extensive pattern of atypical neural speech-sound discrimination in newborns at risk of dyslexia. Clinical Neurophysiology. 2019 May;130(5):634-646. https://doi.org/10.1016/j.clinph.2019.01.019

Author

Thiede, Anja ; Virtala, Paula ; Ala-Kurikka, Iina ; Partanen, Eino ; Huotilainen, Minna ; Mikkola, Kaija ; Leppänen, Paavo ; Kujala, Teija. / An extensive pattern of atypical neural speech-sound discrimination in newborns at risk of dyslexia. In: Clinical Neurophysiology. 2019 ; Vol. 130, No. 5. pp. 634-646.

Bibtex

@article{2e854d27caeb41babcaa3dd91d08840c,
title = "An extensive pattern of atypical neural speech-sound discrimination in newborns at risk of dyslexia",
abstract = "Objective: Developmental dyslexia is usually associated with deficient neural speech-sound processing. Identifying early signs of dyslexia among the at-risk population is paramount to develop interventions that can be applied before school age. Potential early markers of dyslexia may be detected by assessing neural speech processing deficiencies with the mismatch response (MMR).Methods: As the first step of a large-scale longitudinal study, we recorded MMRs to a pseudoword and its variants (changes in vowel duration, sound frequency of syllables, and vowel identity) with electroencephalography (EEG) from 88 newborns either at high familial risk, i.e., with a moderately to severely dyslexic parent, or at no risk, i.e., no dyslexia in close relatives.Results: Abnormal neural discrimination of all speech-sound variants was found in high-risk infants: their MMRs were absent or diminished, had a different morphology and hemispheric lateralization compared to controls.Conclusions: The results suggest an extensive pattern of atypical neural speech-sound discrimination in high-risk newborns.Significance: This weak neural basis for speech discrimination may contribute to impaired language development, potentially leading to future reading problems.",
keywords = "Auditory, Dyslexia, Event-related potential (ERP), Mismatch response (MMR), Newborn, Speech sound",
author = "Anja Thiede and Paula Virtala and Iina Ala-Kurikka and Eino Partanen and Minna Huotilainen and Kaija Mikkola and Paavo Lepp{\"a}nen and Teija Kujala",
year = "2019",
month = "5",
doi = "10.1016/j.clinph.2019.01.019",
language = "English",
volume = "130",
pages = "634--646",
journal = "Clinical Neurophysiology",
issn = "1388-2457",
publisher = "Elsevier Ireland Ltd.",
number = "5",

}

RIS

TY - JOUR

T1 - An extensive pattern of atypical neural speech-sound discrimination in newborns at risk of dyslexia

AU - Thiede, Anja

AU - Virtala, Paula

AU - Ala-Kurikka, Iina

AU - Partanen, Eino

AU - Huotilainen, Minna

AU - Mikkola, Kaija

AU - Leppänen, Paavo

AU - Kujala, Teija

PY - 2019/5

Y1 - 2019/5

N2 - Objective: Developmental dyslexia is usually associated with deficient neural speech-sound processing. Identifying early signs of dyslexia among the at-risk population is paramount to develop interventions that can be applied before school age. Potential early markers of dyslexia may be detected by assessing neural speech processing deficiencies with the mismatch response (MMR).Methods: As the first step of a large-scale longitudinal study, we recorded MMRs to a pseudoword and its variants (changes in vowel duration, sound frequency of syllables, and vowel identity) with electroencephalography (EEG) from 88 newborns either at high familial risk, i.e., with a moderately to severely dyslexic parent, or at no risk, i.e., no dyslexia in close relatives.Results: Abnormal neural discrimination of all speech-sound variants was found in high-risk infants: their MMRs were absent or diminished, had a different morphology and hemispheric lateralization compared to controls.Conclusions: The results suggest an extensive pattern of atypical neural speech-sound discrimination in high-risk newborns.Significance: This weak neural basis for speech discrimination may contribute to impaired language development, potentially leading to future reading problems.

AB - Objective: Developmental dyslexia is usually associated with deficient neural speech-sound processing. Identifying early signs of dyslexia among the at-risk population is paramount to develop interventions that can be applied before school age. Potential early markers of dyslexia may be detected by assessing neural speech processing deficiencies with the mismatch response (MMR).Methods: As the first step of a large-scale longitudinal study, we recorded MMRs to a pseudoword and its variants (changes in vowel duration, sound frequency of syllables, and vowel identity) with electroencephalography (EEG) from 88 newborns either at high familial risk, i.e., with a moderately to severely dyslexic parent, or at no risk, i.e., no dyslexia in close relatives.Results: Abnormal neural discrimination of all speech-sound variants was found in high-risk infants: their MMRs were absent or diminished, had a different morphology and hemispheric lateralization compared to controls.Conclusions: The results suggest an extensive pattern of atypical neural speech-sound discrimination in high-risk newborns.Significance: This weak neural basis for speech discrimination may contribute to impaired language development, potentially leading to future reading problems.

KW - Auditory

KW - Dyslexia

KW - Event-related potential (ERP)

KW - Mismatch response (MMR)

KW - Newborn

KW - Speech sound

U2 - 10.1016/j.clinph.2019.01.019

DO - 10.1016/j.clinph.2019.01.019

M3 - Journal article

VL - 130

SP - 634

EP - 646

JO - Clinical Neurophysiology

JF - Clinical Neurophysiology

SN - 1388-2457

IS - 5

ER -