An evaluation of phase angle, bioelectrical impedance vector analysis and impedance ratio for the assessment of disease status in children with nephrotic syndrome

Steven Brantlov, Lars Jødal, René Frydensbjerg Andersen, Aksel Lange, Søren Rittig, Leigh C Ward

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Abstract

Background: Oedema, characterized by accumulation of extracellular water (ECW), is one of the major clinical manifestations in children suffering from nephrotic syndrome (NS). The lack of a simple, inexpensive and harmless method for assessing ECW may be solved by the use of the bioelectrical impedance analysis (BIA) technique. The aims of this study were to examine whether phase angle (PA), bioelectrical impedance vector analysis (BIVA) and the impedance ratio (IR) reflect change in disease status in children with NS. Methods: Eight children (age range: 2-10 years) with active NS (ANS group) were enrolled. In five of these (ANS*subgroup), impedance was also measured at remission (NSR group). Thirty-eight healthy children (age range: 2-10 years) were included as healthy controls (HC group). Whole-body impedance was measured with a bioimpedance spectroscopy device (Xitron 4200) with surface electrodes placed on the wrist and ankle. Results: Values of PA, BIVA and IR were found to be significantly lower (p-value range < 0.001 to < 0.01) in the ANS patients compared to the HC and NSR groups. No significant differences were observed between the NSR and HC groups. Conclusion: The studied parameters can be used to assess change in disease status in NS patients. Data were consistent with NS being associated with expansion of ECW.

Original languageEnglish
Article number331
JournalBMC Nephrology
Volume20
Issue1
Number of pages10
ISSN1471-2369
DOIs
Publication statusPublished - 1 Jan 2019

Keywords

  • Bioelectrical impedance vector analysis
  • Children
  • Electrical impedance
  • Impedance ratio
  • Nephrotic syndrome
  • Phase angle
  • Total body water
  • MARKER
  • VOLUME
  • BIOIMPEDANCE
  • PREDICTION
  • SPECTROSCOPY
  • BODY-WATER
  • INFANTS
  • MASS
  • VALUES
  • AGE

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