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An atlas of the protein-coding genes in the human, pig, and mouse brain

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  • Evelina Sjöstedt, Department of Protein Science, Science for Life Laboratory, KTH-Royal Institute of Technology, 17121 Stockholm, Sweden.
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  • Wen Zhong, Department of Protein Science, Science for Life Laboratory, KTH-Royal Institute of Technology, 17121 Stockholm, Sweden.
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  • Linn Fagerberg, Department of Protein Science, Science for Life Laboratory, KTH-Royal Institute of Technology, 17121 Stockholm, Sweden.
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  • Max Karlsson, Department of Protein Science, Science for Life Laboratory, KTH-Royal Institute of Technology, 17121 Stockholm, Sweden.
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  • Nicholas Mitsios, Department of Neuroscience, Karolinska Institutet, Stockholm S-171 77, Sweden
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  • Csaba Adori, Department of Neuroscience, Karolinska Institutet, Stockholm S-171 77, Sweden
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  • Per Oksvold, Department of Protein Science, Science for Life Laboratory, KTH-Royal Institute of Technology, 17121 Stockholm, Sweden.
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  • Fredrik Edfors, Department of Protein Science, Science for Life Laboratory, KTH-Royal Institute of Technology, 17121 Stockholm, Sweden.
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  • Agnieszka Limiszewska, Department of Neuroscience, Karolinska Institutet, Stockholm S-171 77, Sweden
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  • Feria Hikmet, Department of Immunology, Genetics and Pathology, Uppsala University, SE-751 85 Uppsala, Sweden.
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  • Jinrong Huang
  • Yutao Du, BGI-Shenzhen, 518083 Shenzhen, China; China National GeneBank-Shenzhen, BGI-Shenzhen, 518083 Shenzhen, China.
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  • Lin Lin
  • Zhanying Dong, Aarhus University, Lars Bolund Institute of Regenerative Medicine, BGI-Qingdao, China., BGI-Shenzhen
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  • Ling Yang, Aarhus University, Lars Bolund Institute of Regenerative Medicine, BGI-Qingdao, China., BGI-Shenzhen
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  • Xin Liu, BGI-Shenzhen, 518083 Shenzhen, China; China National GeneBank-Shenzhen, BGI-Shenzhen, 518083 Shenzhen, China.
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  • Hui Jiang, MGI, BGI-Shenzhen, Shenzhen 518083, China.
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  • Xun Xu, BGI-Shenzhen, 518083 Shenzhen, China; China National GeneBank-Shenzhen, BGI-Shenzhen, 518083 Shenzhen, China.
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  • Jian Wang, BGI-Shenzhen, 518083 Shenzhen, China; China National GeneBank-Shenzhen, BGI-Shenzhen, 518083 Shenzhen, China.
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  • Huanming Yang, BGI-Shenzhen, 518083 Shenzhen, China; China National GeneBank-Shenzhen, BGI-Shenzhen, 518083 Shenzhen, China.
  • ,
  • Lars Bolund
  • Adil Mardinoglu, Department of Protein Science, Science for Life Laboratory, KTH-Royal Institute of Technology, 17121 Stockholm, Sweden.
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  • Cheng Zhang, Department of Protein Science, Science for Life Laboratory, KTH-Royal Institute of Technology, 17121 Stockholm, Sweden.
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  • Kalle von Feilitzen, Department of Protein Science, Science for Life Laboratory, KTH-Royal Institute of Technology, 17121 Stockholm, Sweden.
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  • Cecilia Lindskog, Department of Immunology, Genetics and Pathology, Uppsala University, SE-751 85 Uppsala, Sweden.
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  • Fredrik Pontén, Department of Immunology, Genetics and Pathology, Uppsala University, SE-751 85 Uppsala, Sweden.
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  • Yonglun Luo
  • Tomas Hökfelt, Department of Neuroscience, Karolinska Institutet, Stockholm S-171 77, Sweden
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  • Mathias Uhlén, Department of Protein Science, Science for Life Laboratory, KTH-Royal Institute of Technology, 17121 Stockholm, Sweden.
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  • Jan Mulder, Department of Neuroscience, Karolinska Institutet, 171 77 Stockholm, Sweden. mathias.uhlen@scilifelab.se jan.mulder@ki.se.

The brain, with its diverse physiology and intricate cellular organization, is the most complex organ of the mammalian body. To expand our basic understanding of the neurobiology of the brain and its diseases, we performed a comprehensive molecular dissection of 10 major brain regions and multiple subregions using a variety of transcriptomics methods and antibody-based mapping. This analysis was carried out in the human, pig, and mouse brain to allow the identification of regional expression profiles, as well as to study similarities and differences in expression levels between the three species. The resulting data have been made available in an open-access Brain Atlas resource, part of the Human Protein Atlas, to allow exploration and comparison of the expression of individual protein-coding genes in various parts of the mammalian brain.

Original languageEnglish
Article number5947
JournalScience
Volume367
Issue6482
ISSN0036-8075
DOIs
Publication statusPublished - 2020

Bibliographical note

Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

    Research areas

  • CELLS, EXPRESSION, NEURONS, PITX3, PROMOTER, RECEPTOR, SYSTEM, TYROSINE-HYDROXYLASE

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